Estimating the lifetime utilization rate of radiotherapy in cancer patients: the Multicohort Current Utilization Table (MCUT) method

Extensive research has been carried out to establish the appropriate proportion of cancer patients requiring radiotherapy at some point during their illness. However, it is difficult to compare the actual rates against the appropriate rate, because calculating the actual rates requires life-long follow up of cancer patients. We have developed a method, referred to as the Multicohort Current Utilization Table (MCUT) method, to estimate the predicted lifetime utilization rates based on current medical practice. We implemented the method in SAS as a macro, and validated it by comparing the predicted and the actual utilization rates of radiotherapy in lung, breast, and prostate cancer cases diagnosed in Ontario, Canada. The MCUT method could be used to predict lifetime utilization rate of any medical services.     

Measuring information systems success: models,dimensions, measures,and interrelationships

Since DeLone and McLean (D&M) developed their model of IS success, there has been much research on the topic of success as well as extensions and tests of their model. Using the technique of a qualitative literature review, this research reviews 180 papers found in the academic literature for the period 1992–2007 dealing with some aspect of IS success. Using the six dimensions of the D&M model – system quality, information quality, service quality, use, user satisfaction, and net benefits – 90 empirical studies were examined and the results summarized. Measures for the six success constructs are described and 15 pairwise associations between the success constructs are analyzed. This work builds on the prior research related to IS success by summarizing the measures applied to the evaluation of IS success and by examining the relationships that comprise the D&M IS success model in both individual and organizational contexts.     

An Achilles heel: denial of service attacks on Australian critical information infrastructures

Critical, or national, information infrastructure protection, referred to as either CIIP or NIIP, has been highlighted as a critical factor in overall national security by the United States, the United Kingdom, India and the European Community. As nations move inexorably towards so-called ‘digital economies’, critical infrastructure depends on information systems to process, transfer, store and exchange information through the Internet. Electronic attacks such as denial of service attacks on critical information infrastructures challenge the law and raise concerns. A myriad of issues potentially plague the protection of critical information infrastructures owing to the lack of legal regulation aimed at ensuring the protection of critical information infrastructures. This paper will highlight the legal concerns that relate to the denial of service attacks on critical information infrastructures and provide an introductory overview of the law as it relates to CIIP in Australia.     

Biomarkers in pediatrics: children as biomarker orphans

Biomarkers have enormous potential to improve patient care by establishing tests of diagnosis, prognosis, and treatment effects. Successfully translating a biomarker from discovery to clinical application demands high-quality discovery research and high-quality clinical studies for biomarker validation; however, there are additional challenges that face biomarker research in pediatrics. There are also additional characteristics of pediatric medicine that make biomarker research especially needed. This review focuses on the fundamentals of biomarkers, the additional considerations needed for applying biomarker research to children, and recommendations for advancing pediatric biomarker research.     

Satellite-based estimates of groundwater storage variations in large drainage basins with extensive floodplains

This study presents monthly estimates of groundwater anomalies in a large river basin dominated by extensive floodplains, the Negro River Basin, based on the synergistic analysis using multisatellite observations and hydrological models. For the period 2003-2004, changes in water stored in the aquifer is isolated from the total water storage measured by GRACE by removing contributions of both the surface reservoir, derived from satellite imagery and radar altimetry, and the root zone reservoir simulated by WGHM and LaD hydrological models. The groundwater anomalies show a realistic spatial pattern compared with the hydrogeological map of the basin, and similar temporal variations to local in situ groundwater observations and altimetry-derived level height measurements. Results highlight the potential of combining multiple satellite techniques with hydrological modeling to estimate the evolution of groundwater storage.     

Developing a framework for analyzing IS sourcing

This paper develops a framework for the consideration of internal markets as an alternative to information systems (IS) outsourcing. It is based on an assessment of the pros and cons of both outsourcing and of insourcing based on the internal markets approach. It is formulated in terms of the operational, tactical, and strategic impacts of the choice among the alternatives. The framework, and the propositions that are developed from it, should be useful both for researchers, who can use it for developing testable research hypotheses, and for practitioners, who may use it as a basis for developing a comprehensive set of criteria for the evaluation of these sourcing options.     

Dynamic diamond anvil cell (dDAC): a novel device for studying the dynamic-pressure properties of materials

We have developed a unique device, a dynamic diamond anvil cell (dDAC), which repetitively applies a time-dependent load/pressure profile to a sample. This capability allows studies of the kinetics of phase transitions and metastable phases at compression (strain) rates of up to 500 GPa/s (approximately 0.16 s(-1) for a metal). Our approach adapts electromechanical piezoelectric actuators to a conventional diamond anvil cell design, which enables precise specification and control of a time-dependent applied load/pressure. Existing DAC instrumentation and experimental techniques are easily adapted to the dDAC to measure the properties of a sample under the varying load/pressure conditions. This capability addresses the sparsely studied regime of dynamic phenomena between static research (diamond anvil cells and large volume presses) and dynamic shock-driven experiments (gas guns, explosive, and laser shock). We present an overview of a variety of experimental measurements that can be made with this device.     

Web-collaborative filtering: recommending music by crawling the Web

We show that it is possible to collect data that are useful for collaborative filtering (CF) using an autonomous Web spider. In CF, entities are recommended to a new user based on the stated preferences of other, similar users. We describe a CF spider that collects from the Web lists of semantically related entities. These lists can then be used by existing CF algorithms by encoding them as ‘pseudo-users'. Importantly, the spider can collect useful data without pre-programmed knowledge about the format of particular pages or particular sites. Instead, the CF spider uses commercial Web-search engines to find pages likely to contain lists in the domain of interest, and then applies previously proposed heuristics to extract lists from these pages. We show that data collected by this spider are nearly as effective for CF as data collected from real users, and more effective than data collected by two plausible hand-programmed spiders. In some cases, autonomously spidered data can also be combined with actual user data to improve performance.     

ILSE: The next step in heavy ion fusion research

Induction Linac Systems Experiments is the next experiment planned by the Heavy Ion Fusion Accelerator Research (HIFAR) group at LBL, following the recent completion of the MBE-4 experiment. ILSE at 10 MeV will address many of the key physics and technology issues of HIF such as performance of a multiple beam, high voltage injector, high intensity electrostatically-focused transport, beam combining, high intensity magnetically-focused transport, drift-compression and energy-tilt removal, high intensity transport around a magnetic bend, and, possibly, recirculation. Presuming a new start in FY 94, experiments could begin with ILSE in FY 97.