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121.
I Nishijima T Nakahata S Watanabe K Tsuji I Tanaka Y Hirabayashi T Inoue K Arai 《Canadian Metallurgical Quarterly》1997,90(3):1031-1038
Using a clonal assay of bone marrow (BM) cells from transgenic mice (Tg-mice) expressing the human granulocyte-macrophage colony-stimulating factor receptor (hGM-CSFR), we found in earlier studies that hGM-CSF alone supported the development not only of granulocyte-macrophage colonies, but also of erythrocytes, megakaryocytes, mast cells, blast cells, and mixed hematopoietic colonies. In this report, we evaluated the in vivo effects of hGM-CSF on hematopoietic and lymphopoietic responses in the hGM-CSFR Tg-mice. Administration of this factor to Tg-mice resulted in dose-dependent increases in numbers of reticulocytes and white blood cells (WBCs) in the peripheral blood. Morphological analysis of WBCs showed that the numbers of all types of the cell, including neutrophils, eosinophils, monocytes, and lymphocytes increased; the most remarkable being in lymphocytes that contained a number of large granular lymphocytes (LGLs) in addition to mature T and B cells. However, total cellularity of the BM of the Tg-mice decreased in a dose-dependent manner when hGM-CSF was injected. In sharp contrast to the BM, spleens of the Tg-mice were grossly enlarged. Although all types of blood cells and hematopoietic progenitors increased in the spleen, erythroid cells and their progenitors showed the most significant increase. Increased numbers of megakaryocytes and LGLs were also observed in spleen and liver of the treated Tg-mice. Flow cytometric analysis showed that LGLs expanded in Tg-mice expressed Mac-1+ CD3- NK1.1+. The thymus of Tg-mice treated with hGM-CSF exhibited a dose-dependent shrinkage and a remarkable decrease in CD4+ CD8+ cells. Thus, hGM-CSF stimulated not only myelopoiesis but also erythropoiesis and megakaryopoiesis of hGM-CSFR Tg-mice in vivo, in accordance with our reported in vitro findings. In addition, hGM-CSF affected the development of lymphoid cells, including natural killer cells of these Tg-mice. 相似文献
122.
123.
An equation of state for 1,1-difluoroethane (HFC 152a, CH3CHF2) has been developed on the basis of reliable experimental data including PVT, liquid Cp, and saturated-liquid-density data measured by our group. It is a non-dimensionalized virial equation whose functional form is the same as that originally developed for 1,1,1,2-tetrafluoroethane (HFC 134a) in our group. The effective range is for pressures up to 15 MPa, temperatures from 230 to 450 K, and densities to 1000 kg m−3. The equation represents reliable PVT measurements within ± 1% in pressure for the superheated vapour and supercritical fluid, while within ±0.5% in density for the compressed liquid. In addition, it should be noted that the equation represents the other essential thermodynamic properties including vapour pressures, saturated-liquid/ vapour densities, isobaric/isochoric specific heats and sound velocity in both the liquid and gaseous phase of HFC 152a. 相似文献
124.
The catalytic activity of KGa-priderite, K1.6Ga1.6Ti6.4O16, and its related compound KGa8Ga9Ti15O56 was investigated for the selective reduction of nitrogen monoxide (NO) with propylene (C3H6) in the presence of high oxygen concentrations. The KGa-priderite showed significant activity during this reaction, but the related compound showed only a little activity. These compounds are quite different from the conventional catalysts for NOx selective reduction and are characterized by the fact that their properties are free from the effects of solid acidity and support metals. This difference was attributable to the NO desorption rate at the surface of these compounds. It has become clear that the KGa-priderite catalyst remarkably adsorbed NO, and it is suggested that the amount of NO adsorbed and the amount of catalytic activity are able to be increased by the design of priderite structure. 相似文献
125.
To study the time-course of infectious asthma, we retrospectively examined FEV1 from 5 days before to 10 days after the onset of illness in 31 asthmatic children (20 boys and 11 girls), aged 8 to 12 years. Infections were confirmed by a rise of at least fourfold in serum compliment fixation titers (respiratory syncytial virus, adenovirus, and Mycoplasma pneumoniae) and hemoagglutination inhibition titers (parainfluenza virus types 1, 2, and 3). All the patients had 20 percent or more fall in FEV1 from baseline value during acute phase, but were clinically tolerable and required minimum or no bronchodilators. Regardless of infectious agent, FEV1 began to fall on the first disease day or the previous day, and deteriorate for the first few days. Mean(SD) maximum fall in FEV1 ranged from 39(12) percent to 45(20) percent. Thereafter, FEV1 began to improve and returned to the preillness level by the seventh to tenth day. These results suggest that progressive bronchial obstruction may be inevitable during the acute stage of any infectious asthma. 相似文献
126.
Leo Egghe 《Scientometrics》2005,63(2):277-296
Summary We study new and existing data sets which show that growth rates of sources usually are different from growth rates of items. Examples: references in publications grow with a rate that is different (usually higher) from the growth rate of the publications themselves; article growth rates are different from journal growth rates and so on. In this paper we interpret this phenomenon of “disproportionate growth' in terms of Naranan's growth model and in terms of the self-similar fractal dimension of such an information system, which follows from Naranan's growth model. The main part of the paper is devoted to explain disproportionate growth. We show that the “simple' 2-dimensional informetrics models of source-item relations are not able to explain this but we also show that linear 3-dimensional informetrics (i.e. adding a new source set) is capable to model disproportionate growth. Formulae of such different growth rates are presented using Lotkaian informetrics and new and existing data sets are presented and interpreted in terms of the used linear 3-dimensional model. 相似文献
127.
In connection with the specific features of high velocity aerated flow generated by hydraulic engineering structures, the mathematical model is developed for high turbulence air-water two-phase flow with the use of twin flow theoretical model in this paper. Furthermore the numerical method is proposed to treat bubbled flows. In addition, on the basis of air-water stratified twin flow model, the new calculation methods and free surface tracking technique are proposed to describe complicated movements of the free surface. Finally, the proposed model is used to calculate artificial aerated flows. The computed results coincide quite well with experimental results. This means that the proposed method can provide solid basis for practical engineering design. 相似文献
128.
Although the dams produce remarkable social and economic benefits, the threat made by unsafe dams to the life and property of people who live in the lower river area is un-negligible. Based on the monitoring data which reflect the safety condition of dams, the risk degree concept is proposed and the analysis system and model for evaluating risk degree (rate) are established in this paper by combining the reliability theory and field monitoring data. The analysis method for risk degree is presented based on Bayesian approach. A five-grade risk degree system for dam operation risk and corresponding risk degree is put forward according to the safety condition of dams. The operation risks of four cascade dams on some river are analyzed by the model and approach presented here and the result is adopted by the owner. 相似文献
129.
Fanggao Chang Tao Li Yongxia Ge Zhenping Chen Zhongshi Liu Xiping Jing 《Journal of Materials Science》2007,42(17):7109-7115
DC resistivity, dielectric constant, dielectric loss and positron annihilation spectra of (Ba1−x
Ho
x
)TiO3 ceramics have been measured as a function of holmium concentration x. It has been found that the DC resistivity of (Ba1−x
Ho
x
)TiO3 is strongly dependent on the Ho content: it decreases three orders of magnitude and reaches a minimum at x = 0.4%. Doping with 0.6% holmium increases the permittivity of BaTiO3 by approximately three times (from ∼1,300 to ∼4,000), with only a slight increase in the corresponding dielectric loss. The
local electron density and defect concentration estimated using positron annihilation technique conforms well to the features
found in the dielectric and resistivity measurements. The results have been discussed in terms of a mixed compensation model. 相似文献
130.
R. Dinesh T. Fujiwara T. Watanabe K. Byrappa M. Yoshimura 《Journal of Materials Science》2006,41(5):1541-1546
A well-crystallized AMO4 (A=Ba, Ca, Sr; M=W, Mo) films have been prepared at room temperature through a simple solution reaction in respective alkaline
solution at higher pH ranging from 12–14. Adopting the corrosion principle for oxidation of metal substrate, these double
oxide films were carried out in presence of chemical driving force without any special apparatus or devices. Hydrogen peroxide
was used to enhance the dissolution rate of metal substrates. The driving force for the film formation and growth were high
concentration of A2+, MO42− ions with high pH conditions. Average grain sizes of 8–10 μm with bipyramidal shaped particle were grown to the thickness
of about 10–14 μm after 3–6 hours treatment. The crystallization of AMO4 was characterized by three-dimensional nucleation. This work demonstrates the possibility of fabrication of functional ceramic
films directly from the aqueous solution in a single step by solution reactions. 相似文献