Evolutionary algorithms and de novo peptide design

One of the goals of computational chemistry is the automated de novo design of bioactive molecules. Despite significant progress in computational approaches to ligand design and efficient evaluation of binding energy, novel procedures for ligand design are required. Evolutionary computation provides a new approach to this design issue. This paper presents an automated methodology for computer-aided peptide design based on evolutionary algorithms. It provides an automatic tool for peptide de novo design, based on protein surface patches defined by user. Regarding the restrictive constrains of this problem a special emphasis has been made on the design of the evolutionary algorithms implemented.     

Systematic characterization of Cl2 reactive ion etchingfor improved ohmics in AlGaN/GaN HEMTs

Pre-metal-deposition reactive ion etching (RIE) was performed on an Al_0.3Ga_0.7N/AlN/GaN heterostructure in order to improve the metal-to-semiconductor contact resistance. An optimum AlGaN thickness for minimizing contact resistance was determined. An initial decrease in contact resistance with etching time was explained in terms of removal of an oxide surface layer and/or by an increase in tunnelling current with the decrease of the AlGaN thickness. The presence of a dissimilar surface layer was confirmed by an initial nonuniform etch depth rate. An increase in contact resistance for deeper etches was experienced. The increase was related to depletion of the two-dimensional (2-D) electron gas (2-DEG) under the ohmics. Etch depths were measured by atomic force microscopy (AFM). The contact resistance decreased from about 0.45 Ωmm for unetched ohmics to a minimum of 0.27 Ωmm for 70 Å etched ohmics. The initial thickness of the AlGaN layer was 250 Å. The decrease in contact resistance, without excessive complications on device processing, supports RIE etching as a viable solution to improve ohmic contact resistance in AlGaN/GaN HEMTs     

用仿真工具优化车辆动力系统(一)

在本文的第一部分，介绍了一种理想的车辆动力系统的计算机辅助开发过程。它显示了现代仿真技术在产品持续发展过程中的作用，该技术采用硬件回路作非在线的仿真，并通过现代化的试验手段对车辆进行匹配。特别重要的是提供了将电控变速器和发动机控制单元综合的可能性。接着是在线仿真在诸如发动机和变速器模式方面的应用和发展，它是上述开发过程的基础。根据上述的方法论，本文论述了仿真技术已取得的成绩和将来的应用可能性。     

0. 6 􀀁m CMOS 雷达天线专用控制芯片设计

雷达系统中天线控制电路完成上位机的初始化和扫描角度控制,要求具有高可靠性和低静态电流,用专用集成电路进行设计具有明显优势.采用Verilog HDL语言描述了系统的逻辑功能,超前进位结构的加/减法器提高了电路的工作速度.利用0.6 μm CMOS工艺完成了天线控制电路的物理实现,芯片面积为1.695 mm×1.631 mm.     

CCD型束流截面探测器

CCD型束流截面探测器的主要特点是使用电荷耦合器件做传感器,用束流同步光中的可见光成份做为信号源。该探测器同时具有模拟量和数字量两种输出,工作周期短,速度高,不影响束团粒子寿命,在电子储存环物理运行中,是一种有效的探测设备。     

Analog VLSI model of binaural hearing

The stereausis model of biological auditory processing is proposed as a representation that encodes both binaural and spectral information in a unified framework. A working analog VLSI chip that implements this model of early auditory processing in the brain is described. The chip is a 100000-transistor integrated circuit that computes the stereausis representation in real time, using continuous-time analog processing. The chip receives two audio inputs, representing sound entering the two ears, computes the stereausis representation, and generates output signals that can directly drive a color CRT display. Outputs from the chips for a variety of artificial and speech stimuli are shown.     

Vestigial sideband filtering at 10 Gbit/s using 12.5 GHzchannel-spacing demux

A 32-channel 12.5 GHz-spaced free-space demux with low crosstalk and low polarisation dependent loss has been constructed. Using this demux, vestigial sideband filtering at 10 Gbit/s has been studied. It is shown that this demux can achieve very high spectral efficiency without polarisation division multiplexing     

用迭代法消除数字图像放大后的模糊

用迭代法对数字图像经过插值放大后产生的模糊问题进行了研究，把数字图像插值放大造成的模糊看成是点扩散函数与清晰图像卷积的结果，根据插值算法可以得到点扩散函数，由于数字图像解卷积是典型的解线性方程组的问题，用雅可比（Jacobi）迭代法得到了很好的结果。与频谱空间变换的方法相比，迭代法没有分母为0的问题和空间变换过程造成的舍入误差。     

How Japan's Recently Amended Copyright Law Affects Software

Japan rejected a proposal to adopt a special software protection law and instead modified its copyright law to include software. This change may affect US firms doing business there.