A new efficient method for one‐pot conversions of aryl carboxylic acids into nitriles without solvent

A new efficient method for synthesising nitriles, important organic reagents, is reported in this paper. In an environmentally benign solvent‐free system, aryl carboxylic acids were converted into the corresponding nitriles via one‐pot reactions, by amidation with ethyl carbamate followed by dehydration with thionyl chloride, in excellent yields. The results showed that the method has the advantages of lower cost, higher yield, less pollution and greater ease of work‐up. Copyright © 2008 Society of Chemical Industry     

温度敏感葡聚糖凝胶的合成及其细胞相容性研究

合成了N-异丙基丙烯酰胺（NIPAAm）与葡聚糖的共聚水凝胶，利用红外光谱表征了单体和凝胶结构，研究了水凝胶在去离子水和细胞培养基中的温度响应性，并对凝胶进行了细胞培养和脱附研究．结果表明，共聚凝胶具有很好的温度敏感性和细胞相容性，可以通过控制温度变化，实现对细胞的无损伤脱附．     

In situ formation of multi scale reinforcing phases to improve performance of Al2O3-SiC C castables

In order to improve the physical properties and slag corrosion resistance of refractory materials for hot metal pretreatment, different contents of composite metal powders (CMP) were introduced into Al2O3-SiC-C refractory castables. The effect of CMP on the microstructure, physical properties and slag corrosion resistance of Al2O3-SiC-C refractory castables were studied. The results show that the multi scale reinforcing phases including flake crystals, rod shaped fibers, filamentous fibers and whiskers are in situ formed in the samples with addition of CMP, which result to the improvement of the cold modulus of rupture and cold crushing strength. When the addition of CMP is 6 wt.%, the high temperature modulus of rupture increases by 231%, the thermal shock resistance increases by 77% after thermal shock by water cooling 5 times and the percentage of the slag resistant area reduces by 37.2%.     

利用铝（100）面隧道孔制备纳米模板及有序阵列材料

高纯铝箔通常通过电化学扩面后用作铝电解电容器的阳极材料。利用铝箔（100）面隧道孔制备纳米模板。这种纳米模板的特点是制作简单、模板面积大，纳米阵列材料形状可控性强。还利用两步电化学侵蚀铝箔的特殊工艺，研制出纵横交错的TiO2纳米有序阵列材料。     

铁素体球墨铸铁与20钢的闪光对焊

试验使用铁素体球墨铸铁和20钢的实心棒料进行了闪光对焊，通过改变次级电压4～8级，通电时间3～5s，观察其焊接接头组织的变化并测定其抗拉强度。结果表明，接头由三个区组成；当通电时间一定时，抗拉强度随次级电压的升高先减小后增大；当次级电压一定时，抗拉强度随通电时间的增加而增大。在次级电压为8级、通电时间为5s时，抗拉强度达最大值，为370．8MPa，是20钢母材的90.4％，是球墨铸铁母材的83.7％。     

Modeling for local dynamic behaviors of phenol biodegradation in bubble columns

A coupled three-dimensional (3-D) model, combining hydrodynamics with biochemical reactions, was developed to simulate the local transient flow patterns and the dynamic behaviors of cell growth and phenol biodegradation by yeast Candida tropicalis in the bubble-column bioreactor, using the computational fluid dynamic (CFD) method. In order to validate this proposed model effectively, the validation of the local hydrodynamic characteristics of the gas-mineral salt solution (gas-liquid) two-phase system, with the phenol concentration of 1200 mg/L, and with the absence of cells, was performed in a square-sectioned bubble column bioreactor using the LDA system and conductivity probe. Furthermore, the validation of phenol biodegradation behaviors by yeast Candida tropicalis at different initial concentrations of phenol and cell was also carried out in the above bubble-column bioreactor. The results indicated that the model simulations had a satisfying agreement with the experimental data. Finally, the local instantaneous flow and phenol biodegradation features including gas holdup, gas velocity, liquid velocity, cell concentration and phenol concentration inside the bioreactor were successfully predicted in different-scale bubble columns by the proposed model. © 2006 American Institute of Chemical Engineers AIChE J, 2006     

Hydrothermal Reaction Mechanism and Pathway for the Formation of K2Ti6O13 Nanowires

Calculations and detailed first principle and thermodynamic analyses have been performed to understand the formation mechanism of K₂Ti₆O₁₃ nanowires (NWs) by a hydrothermal reaction between bulk Na₂Ti₃O₇ crystals and a KOH solution. It is found that direct ion exchange between K⁺ and Na⁺ plus H⁺ interactions with [TiO₆] octahedra in Na₂Ti₃O₇ promote the formation of an intermediate H₂K₂Ti₆O₁₄ phase. The large lattice mismatch between this intermediate phase and the bulk Na₂Ti₃O₇ structure, and the large energy reduction associated with the formation of this intermediate phase, drive the splitting of the bulk crystal into H₂K₂Ti₆O₁₄ NWs. However, these NWs are not stable because of large [TiO₆] octahedra distortion and are subject to a dehydration process, which results in uniform K₂Ti₆O₁₃ NWs with narrowly distributed diameters of around 10 nm.     

Diameter NASREQ协议在卫星移动通信系统中的应用研究

如何对接入网络的用户进行身份认证、授予相应权限并进行计费,是卫星移动通信系统网络管理需解决的重要问题。简要介绍认证、授权、计费(AAA)的基本概念,分析Diameter协议框架、协议原理以及协议应用于网络接入的特点。阐述协议中包含的各种应用,给出Diameter NASREQ应用的一种系统模型。重点研究Diameter NASREQ协议在卫星移动通信系统中的应用,详述应用中客户机和服务器中各模块的功能和工作原理。通过分析,说明该应用的可行性及有效性。     

A 3-D Enlarged Cell Technique (ECT) for the Conformal FDTD Method

In this paper, we present an enlarged cell technique (ECT) to avoid the time step reduction encountered in the conformal finite-difference time-domain (CFDTD) method due to small irregular cells truncated by metallic boundaries. We focus our efforts on the discussion of the accuracy and stability of the ECT and its comparison with other conformal methods, especially the one called the uniformly stable conformal (USC) method. We also provide a simplified ECT, which is much easier to implement. In the ECT, a stability criterion is first constructed to identify instable irregular cells, i.e., those having so small an area to cause instability. Those instable cells are then enlarged into their adjacent cells to obtain a large, stable area. Careful treatment is performed on the communication between the intruding and intruded cells in terms of electromotive force by keeping the total electromotive force conservative. This technique is verified by several 3-D numerical experiments. Results show that the ECT is second-order accurate and numerically stable at the regular Courant time step limit.     

靶向抗癌药格列卫与其治疗白血病疗效监测

Gleevec是抑制致癌的融合蛋白BCR-ABL的一种分子靶向治疗药物,BCR-ABL是一种与慢性髓细胞性白血病(CML)有关的酪氨酸激酶抑制剂。用Gleevec选择性地抑制BCR-ABL活性在治疗CML中显示出很好的效果,特别是在CML慢性期,因此,监测疗效非常重要。现就Gleevec的研究进展及如何监测其在CML中的疗效作一简单综述。