聚合酶β在肝癌细胞DNA辐射损伤修复中的作用

利用第二军医大学裸鼠移植性肝癌细胞（ＳＭＭＣ－ＬＴＮＭ）和不同的ＤＮＡ聚合酶选择性抑制剂ＮＥＭ与ｄ２ＴＴＰ，探讨了肿瘤细胞核中ＤＮＡ聚合酶β参与γ射线辐射损伤ＤＮＡ修复的作用特点，结果表明，该酶参与真核细胞γ射线辐照损伤的ＤＮＡ修复合成，是一种重要的ＤＮＡ修复酶，与正常肝细胞相比，ＳＭＭＣ－ＬＴＮＭ肝癌细胞ＤＮＡ聚合酶β的ＤＮＡ修复合成反应速度快，修复能力强，提示某些肿瘤细胞中该酶的ＤＮＡ辐射损伤     

Effect of H_2 dilution on the structure and properties of nc-CrC/a-C:H coatings deposited by a hybrid beams system

Nanocomposite Cr C/hydrogenated amorphous carbon(nc-CrC/a-C:H) coatings were deposited by a hybrid beams system comprised of a hollow cathode ion source and a cathodic arc ion-plating unit with varying H_2 flow rates. The influences of H_2 flow rates on the morphologies, microstructures, and properties of the coatings were systematically studied. The morphologies and microstructures of the coatings were characterized by SEM, AFM, XPS, Raman spectroscopy, GIXRD, and HRTEM. The mechanical and tribological properties were measured by a nano-indenter, scratch tester, and ball-ondisk tribometer. The wear tracks were evaluated using 3D profilometer, optical microscope, and EDS analysis. It has been found that a moderate H_2 flow rate can effectively smooth the surface, enlarge the fraction of a sp~3 bond, and improve the properties. The coating exhibits the highest hardness and elastic modulus at the H_2 flow rate of 40 sccm. A superior combination of adhesion strength,friction coefficient, and wear resistance can be achieved at the H_2 flow rate of 80 sccm.     

Radionuclides in primary coolant of a fluoride salt-cooled high-temperature reactor during normal operation

The release of fission products from coated particle fuel to primary coolant,as well as the activation of coolant and impurities,were analysed for a fluoride salt-cooled high-temperature reactor (FHR) system,and the activity of radionuclides accumulated in the coolant during normal operation was calculated.The release rate (release fraction per unit time) of fission products was calculated with STACY code,which is modelled mainly based on the Fick's law,while the activation of coolant and impurities was calculated with SCALE code.The accumulation of radionuclides in the coolant has been calculated with a simplified model,which is generally a time integration considering the generation and decay of radionuclides.The results show that activation products are the dominant gamma source in the primary coolant system during normal operation of the FHR while fission products become the dominant source after shutdown.In operation condition,health-impacts related nuclides such as 3H,and 14C originate from the activation of lithium and coolant impurities including carbon,nitrogen,and oxygen.According to the calculated effective cross sections of neutron activation,6Li and 14N are the dominant 3H production source and 14C production source,respectively.Considering the high production rate,3H and 14C should be treated before being released to the environment.     

软件漏洞模糊测试的关键分支探索及热点更新算法

在软件开发及应用中,由于具有可复现性,模糊测试能够帮助发现漏洞和有针对性地对漏洞成因进行分析。为了解决模糊测试过程的效率及测试力度等问题,提出了软件漏洞模糊测试的关键分支探索及热点更新算法。该方法通过捕获、分析和利用受检程序在处理测试用例时的执行位置的关键信息,以指导模糊测试过程的探索方向和测试用例的生成。实验结果表明,提出的方法相较于传统随机发散的模糊测试方法在漏洞发现能力上有较大提升,在Otfcc、Swftools等14个开源程序中发现了100余个未被公布的漏洞,为模糊测试用于软件漏洞检测提供了新的可靠途径。     

小波瀑布型多重网格法

为了提高偏微分方程的计算精度,由瀑布型多重网格的速度收敛快以及小波多分辨分析的性质,通过改进传统瀑布型多重网格算法中的插值算子,提出一种新的小波瀑布型多重网格方法。数值结果表明,小波瀑布型多重网格方法比传统的瀑布型多重网格方法具有更高精度。     

二层交换机的攻击分析与防范技术的研究

本文通过OSI模型的第二层的特点,分析了二层交换机存在的安全隐患,提出了相应的解决办法。     

Fabrication of Cu(In,Ga)Se2 thin films by ion beam sputtering deposition from a quaternary target at different substrate temperatures

Cu(In, Ga)Se₂ (CIGS) thin films were fabricated by ion beam sputtering deposition from a single quaternary target at different substrate temperatures (T _sub). The thin films were characterized with X-ray diffractometry, scanning electron microscopy, energy-dispersive X-ray spectroscopy and four-point probe technique to study the microstructures, surface morphology, composition and electrical properties, respectively. The results show that the films grown above 400?°C are of chalcopyrite structure. Cu(In_0.7Ga_0.3)Se₂ thin film was obtained when T _sub is 550?°C. The Cu and Se atomic percentage when T _sub is above 500?°C is higher than when T _sub is below 500?°C. With the increase in T _sub, the surfaces morphology of the films is denser and the resistivity of the films decreases.     

国内外环氧树脂的生产现状及应用进展

本文阐述国内外环氧树脂发展动向及应用进展。     

高速定时分件供送螺杆系统研究新进展──变螺距螺旋线设计新方法初探

着重阐述在高速定时分件供送螺杆基础理论的系统研究中，长期以来未能很好解决的一些难题，进一步探讨合理设计变螺距螺旋线的新方法以及确定有关参数的若干准则。