基于共形稀疏阵列的艇载外辐射源雷达性能分析

该文研究了共形稀疏阵列在艇载外辐射源雷达中的应用问题,并分析了艇载外辐射源雷达目标探测性能。鉴于天线在雷达系统中的重要地位,重点分析了稀疏阵列数字波束形成(DBF)天线的布阵方式及天线方向图指标。基于组合巴克码实现艇身稀疏阵列共形布设,提出一种曲线阵列到直线阵列的补偿方法,以获得理想的DBF天线方向图。针对曲线阵列可能存在的形变问题,采用分布式位置和姿态测量系统(POS)进行形变误差测量,经曲线拟合后实施精确补偿。仿真结果表明所提方法的有效性。     

Design of cavern blasting based on controllable parameters

After a thorough review of some controllable parameters, which included field investigations, cavern dimensions, explosive, rock strength etc., cut, contour, lifters and stoping holes were introduced for blasting cavern of nucleus submarine. These design were conducted using a U. Langefors and B. Kihlstrom theory. Supported by the Navy Cavern Project Foundation of China (02)     

金刚石滚轮修整效果与修整机理

在锥面包络圆柱蜗杆状珩磨轮（ZK型）珩齿加工中,通常采用直廓金刚石滚轮修整得到的蜗杆状珩磨轮代替渐开线蜗杆状珩磨轮进行珩齿加工,在原理上引入了误差.为研究原理误差大小及影响因素,运用空间啮合原理,对近似模型的珩齿加工过程进行建模,得出加工齿轮齿面模型法向误差.以具体参数蜗杆与齿轮为例,绘制加工齿轮齿面模型上不同位置处的法向误差分布图.分析了蜗杆状珩磨轮螺旋角（蜗杆直径、头数）与压力角对加工齿轮齿面模型法向误差的影响.结果表明：蜗杆状珩磨轮螺旋角越大,加工齿轮齿面模型法向误差越小;待加工压力角较小的齿轮,更适合用文中近似模型进行珩齿加工.研究结果验证了运用锥面包络圆柱蜗杆珩齿加工的可行性,对珩齿加工具有现实指导意义.

     

苏州古典园林纹样涵义的追溯

该文集中对苏州古典园林中的纹样进行分析,探究其文化涵义,文章分经典著作中的纹样涵义追溯、现存纹样涵义的追溯和作为纹样的文字涵义追溯三部分,以期获得对文化遗产古典园林纹样的正确解释。     

Agglomeration Mechanism of Complex Ti-Al Oxides in Liquid Ferrous Alloys Considering High-Temperature Interfacial Phenomenon

Metallurgical and Materials Transactions B - This work presents the agglomeration mechanism of complex Ti-Al oxides in the liquid ferrous alloy. Cluster characteristics were investigated using Al...     

Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence,Severity, and Treatment Response

Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, severity, and treatment response in OSA. Participants (n = 1391) of the Stanford Technology Analytics and Genomics in Sleep study had blood collected and completed an overnight polysomnography for scoring the apnea–hypopnea index (AHI). A highly multiplexed aptamer-based array (SomaScan) was used to quantify 5000 proteins in all plasma samples. Two separate intervention-based cohorts with sleep apnea (n = 41) provided samples pre- and post-continuous/positive airway pressure (CPAP/PAP). Multivariate analyses identified 84 proteins (47 positively, 37 negatively) associated with AHI after correction for multiple testing. Of the top 15 features from a machine learning classifier for AHI ≥ 15 vs. AHI < 15 (Area Under the Curve (AUC) = 0.74), 8 were significant markers of both AHI and OSA from multivariate analyses. Exploration of pre- and post-intervention analysis identified 5 of the 84 proteins to be significantly decreased following CPAP/PAP treatment, with pathways involving endothelial function, blood coagulation, and inflammatory response. The present study identified PAI-1, tPA, and sE-Selectin as key biomarkers and suggests that endothelial dysfunction and increased coagulopathy are important consequences of OSA, which may explain the association with cardiovascular disease and stroke.     

海上平台电气系统无人化方案设计

目前国内外越来越多边际油田开发借助无人平台来实现,降低油田开发成本的同时,也对平台生产安全提出更高要求。无人平台电气系统的设计以系统网架结构简化为基础,以实现全面监测、远程调控和安全可靠运行为目的,以现有能量管理系统为基础平台,将电气系统、能量管理系统及各设备监测系统等联合实现远程管控,从而为海上油气生产提供可靠、安全的供电保障。主要探讨海上油气田工程设施电气无人化的设计方法,结合南海某海上油田工程设计案例,详细论述无人平台电气设计方案,从具体设计工作中提炼出符合海上平台电气系统的无人化通用做法,为海上油气田无人化的推广应用以及无人平台电气系统的设计提供参考和借鉴。     

A Fully-Human Antibody Specifically Targeting a Membrane-Bound Fragment of CADM1 Potentiates the T Cell-Mediated Death of Human Small-Cell Lung Cancer Cells

Small-cell lung cancer (SCLC) is the most aggressive form of lung cancer and the leading cause of global cancer-related mortality. Despite the earlier identification of membrane-proximal cleavage of cell adhesion molecule 1 (CADM1) in cancers, the role of the membrane-bound fragment of CAMD1 (MF-CADM1) is yet to be clearly identified. In this study, we first isolated MF-CADM1-specific fully human single-chain variable fragments (scFvs) from the human synthetic scFv antibody library using the phage display technology. Following the selected scFv conversion to human immunoglobulin G1 (IgG1) scFv-Fc antibodies (K103.1–4), multiple characterization studies, including antibody cross-species reactivity, purity, production yield, and binding affinity, were verified. Finally, via intensive in vitro efficacy and toxicity evaluation studies, we identified K103.3 as a lead antibody that potently promotes the death of human SCLC cell lines, including NCI-H69, NCI-H146, and NCI-H187, by activated Jurkat T cells without severe endothelial toxicity. Taken together, these findings suggest that antibody-based targeting of MF-CADM1 may be an effective strategy to potentiate T cell-mediated SCLC death, and MF-CADM1 may be a novel potential therapeutic target in SCLC for antibody therapy.     

失效模式及后果分析的运用

介绍FMEA——国外汽车制造商在产品及工艺开发过程中普遍采用的对产品及工艺进行预测和评估的方法。它 将对完善设计、预防和纠正生产过程中可能造成产品报废或瑕疵的错误起到有效的作用。     

Tuning Weld Metal Mechanical Responses via Welding Flux Optimization of TiO2 Content: Application into EH36 Shipbuilding Steel

Metallurgical and Materials Transactions B - A series of TiO2-containing basic-fluoride-type agglomerated fluxes was applied to join EH36 shipbuilding steel under high heat input SAW. The effects...