1‐Arylsulfonyl‐5‐(N‐hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

A series of 1‐arylsulfonyl‐5‐(N‐hydroxyacrylamide)indolines ( 7 – 15 ) has been developed; the compounds exhibited potent histone deacetylase (HDAC) inhibitory activities. Notably, almost all of this series exhibited better HDAC‐inhibitory and antiproliferative activities than 3‐(1‐benzenesulfonyl‐1H‐indol‐5‐yl)‐N‐hydroxyacrylamide ( 6 ), as reported in a previous study. Among these compounds, 3‐[1‐(4‐methoxybenzenesulfonyl)‐2,3‐dihydro‐1H‐indol‐5‐yl]‐N‐hydroxyacrylamide ( 9 ) showed a two‐ to tenfold increase in activity compared to SAHA ( 1 ) in the suppression of lipopolysaccharide‐induced cytokine production. Compound 9 also caused a marked reduction in carrageenan‐induced acute inflammation in a rat model. Taken together, these data indicated that 1‐arylsulfonyl‐5‐(N‐hydroxyacrylamide)indolines HDAC inhibitors exhibit potent anti‐inflammatory activity.     

Validation of bulk-charge effect parameter extraction in MOSFETs

Our recently proposed method to extract the bulk-charge effect parameter in MOSFETs is scrutinized by studying SOI devices, a-Si:H TFTs and short- as well as long-channel bulk MOSFETs. The method requires measuring the drain current as a function of gate voltage at two small values of drain voltage chosen in the linear region of operation.     

Language supports for journal abstract writing across disciplines

Various writing assistance tools have been developed through efforts in the areas of natural language processing with different degrees of success of curriculum integration depending on their functional rigor and pedagogical designs. In this paper, we developed a system, WriteAhead, that provides six types of suggestions when non‐native graduate students of English from different disciplines are composing journal abstracts, and assessed its effectiveness. The method involved automatically building domain‐specific corpora of abstracts from the Web via domain names and related keywords as query expansions, and automatically extracting vocabulary and n‐grams from the corpora in order to offer writing suggestions. At runtime, learners' input in the writing area of the system actively triggered a set of corresponding writing suggestions. This abstract writing assistant system facilitates interactions between learners and the system for writing abstracts in an effective and contextualized way, by providing suggestions such as collocations or transitional words. For assessment of WriteAhead, we compared the writing performance of two groups of students with or without using the system, and adopted student perception data. Findings show that the experiment group wrote better, and most students were satisfied with the system concerning most suggestion types, as they can effectively compose quality abstracts through provided language supports from WriteAhead.     

Solution of low péclet number heat transfer with viscous dissipation in the semi‐infinite axial region of a tube via functional analytic methods

Abstract

A solution of the extended Graetz problem with prescribed wall heat flux and viscous dissipation in a semi‐infinite axial region of a tube is obtained by functional analytic methods. The energy equation is split into a set of partial differential equations to obtain a self‐adjoint formulism. Then, an algebraic characteristic equation of the eigenvalue problem for an arbitrary velocity profile is obtained by an approximation method in L ₂[0, 1]. In addition, a backward recursive formula for calculating the expansion coefficients of the solution is developed.     

Electrostatic discharge in semiconductor devices: protectiontechniques

Electrostatic discharges (ESDs) are everywhere-in our homes and businesses. Even the manufacturers of the electronics experience ESD failures in their factories. Electronic devices are sensitive to ESD. ESD results in failure of our computers, calculators, and car phones. There are ways to protect these sensitive components. This paper looks at ESD protection from a two-pronged approach: reducing the likelihood of having an ESD event and improving the robustness of the devices themselves. The first approach focuses on reducing the amount of charge that is developed and controlling the redistribution of any charges that are developed The second approach reviews ways to improve the circuit robustness by improving individual circuit elements and by adding additional elements for charge flow control and voltage clamping     

Analysis of the dielectric characteristics for polycrystalline Ba0.65Sr0.35TiO3 (II) – d.c. field dependence with a modified bias equation

The effect of direct-current (d.c.) biasing on the dielectric properties of Ba_0.65Sr_0.35TiO₃ (BST) with various grain sizes (0.87 μm to 5.43 μm) have been studied in the paraelectric state. The leakage current of BST samples is proportional to the biasing field. Specimens with larger grains exhibit higher leakage current under biasing. The bias equation used in the literature to predict the d.c. field dependence of permittivity is modified by introducing a bias exponent parameter β. This modified bias equation gives a better fit to the experimental results both in this study and in the literature. Similar trends of α (representing the distribution of relaxation times), β, and the variance of lattice distortion with grain sizes suggests that β is a material parameter. It is concluded that the temperature dependence, the frequency response and d.c. field effect for the dielectric characteristics of Ba_0.65Sr_0.35TiO₃ are all suppressed by the transition broadening.     

Failure mechanism and SPICE modeling of AlGaAs/GaAs HBT long-term current instability

The long-term current instability of AlGaAs/GaAs heterojunction bipolar transistor (HBT) is studied, and the physical mechanism contributing to such a behavior is investigated. Based on this, a model capable of predicting the HBT long-term current drift and mean time to failure (MTTF) is developed. In addition, such a model is implemented into SPICE circuit simulator, thus allowing the simulation of HBT circuits subjected to an electrical and thermal stress condition.     

Operation of integrated InGaAsP-InP optical amplifier-monitoringdetector with feedback control circuit

Monolithic integration of a monitoring detector with an optical amplifier simplifies the use of an amplifier in lightwave systems. The structure and performance are described of a monolithically integrated semiconductor optical amplifier with low-loss Y-branching waveguides and a monitoring p-i-n detector. The photocurrent of the integrated detector can be used as a single control parameter for amplifier output leveling, gain optimization, and in situ monitoring of facet antireflective coatings     

微量调速阀抗污染机理研究

本文分析和证明了微量调速阀在实现2-100ml/min 的微量控制时,其压力补偿器的结构性自动抗污染机理和阀具有的综合抗污染性能、其抗污染的机理和性能对设计和研究低污染敏感度的液压元件有实际的指导意义.     

虚拟仪器在1553B总线通信系统中的应用

现代航空通信系统大多建立MIL－STD－1553B多路传输数据总线通信网络基础上，应用于1553B总线通信系统中的虚拟仪器技术实时监控／回放总线信息，分析故障原因，协助验证总线设计。本文就虚拟仪器在1553B总线通信系统中的应用进行了初步探讨。