基于IAHP-GRA 的单元体发动机修理级别分析

针对现行整机维修的决策维修方案已不能满足单元体发动机使用保障要求的问题,提出一种基于IAHP-GRA的单元体发动机的修理级别分析方法。该方法采用单元体发动机的特点制定了修理级别分析评价指标体系,利用最优传递矩阵的性质对层次分析法进行改进,结合灰色关联分析方法对单元体发动机的修理级别方案分析进行了优化决策建模。算例验证结果表明:该方法是合理、科学的。     

Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS-CoV-2 Papain-Like Protease

The two SARS-CoV-2 proteases, i. e. the main protease (M^pro) and the papain-like protease (PL^pro), which hydrolyze the viral polypeptide chain giving functional non-structural proteins, are essential for viral replication and are medicinal chemistry targets. We report a high-throughput mass spectrometry (MS)-based assay which directly monitors PL^pro catalysis in vitro. The assay was applied to investigate the effect of reported small-molecule PL^pro inhibitors and selected M^pro inhibitors on PL^pro catalysis. The results reveal that some, but not all, PL^pro inhibitor potencies differ substantially from those obtained using fluorescence-based assays. Some substrate-competing M^pro inhibitors, notably PF-07321332 (nirmatrelvir) which is in clinical development, do not inhibit PL^pro. Less selective M^pro inhibitors, e. g. auranofin, inhibit PL^pro, highlighting the potential for dual PL^pro/M^pro inhibition. MS-based PL^pro assays, which are orthogonal to widely employed fluorescence-based assays, are of utility in validating inhibitor potencies, especially for inhibitors operating by non-covalent mechanisms.     

红谷黄酒发酵过程中微生物多样性与理化指标、挥发性风味的相关性分析

为探究红谷黄酒发酵过程中微生物群落与理化指标、挥发性风味之间的相关性,本研究通过微生物高通量测序技术、理化指标检测及气相色谱-质谱技术等对黄酒样品进行测定并用SPSS软件进行相关性分析。结果显示随着发酵的进行,还原糖含量在初期急剧下降后逐渐稳定,酒精度变化与之相反;总酸含量先快速增加后减少再增加,pH较为稳定;氨基态氮含量先波动增加后急剧上升,可溶性固形物含量先剧烈下降后趋于稳定。发酵过程中10次取样（1～7、10、20、30 d）共检测出14个细菌门和228个细菌属;7个真菌门和108个真菌属。在属水平细菌群落可聚类为3类,真菌群落可聚类为5类。细菌属水平与总酸显著正相关（P<0.05）,与还原糖显著负相关（P<0.05）,真菌属水平与氨基态氮显著正相关（P<0.05）。2,3-丁二醇以及乳酸乙酯与大部分菌属显著正相关（P<0.05）。Klebsiella与辛酸乙酯显著负相关（P<0.05）;Lactococcus与乙醇、2-丁醇、异丁醇、苯乙醇和棕榈酸乙酯呈显著负相关（P<0.05）。Monascus与乳酸乙酯显著负相关（P<0.05）;A...     

TiAl/40Cr扩散焊界面质量的超声评价

采用超声C扫描法对TiAl和40Cr扩散焊界面进行了检测,分别研究了界面回波幅度平均值和标准差与接头抗剪强度之间的关系,并讨论了焊接温度和试样表面粗糙度对上述关系的影响及界面气隙长度与回波幅度的关系.结果表明,当试样表面粗糙度一致时,回波幅度平均值和标准差随着抗剪强度的降低而增加.表面粗糙度会影响回波幅度平均值和标准差与接头抗剪强度的关系.当空气间隙的长度小于400 μm时,回波幅度与空气间隙长度近似成正比例关系.     

基于旋转变换的混沌光学图像加密方法

提出了一种利用旋转变换和混沌理论进行图像加密的新方法.使用旋转变换和两个混沌随机相位掩膜对图像进行加密,利用Logistic映射、帐篷映射和Kaplan-Yorke映射三种混沌函数产生混沌随机相位掩膜.通过计算均方差,基于旋转角和混沌随机相位的种子值的盲解密算法的鲁棒性进行了评估,并给出了加密和解密技术的光学实现方案....     

Directional sliding of water: biomimetic snake scale surfaces

Bioinspired superhydrophobic surfaces have attracted many industrial and academic interests in recent years. Inspired by unique superhydrophobicity and anisotro...     

A novel Variable-Length Code for robust video coding

A novel Variable-Length Code （VLC）, called Alternate VLC （AVLC）, is proposed in this letter, which employs two types of VLC to encode source symbols alternately. Its advantage is that it can not only stop the symbol error propagation effect, but also correct symbol insertion errors and avoid symbol deletion errors, so the original sequence number of symbols can be kept correctly, which is very important in video communication.     

主回路滞流分支管振动超标的原因分析与设计优化

在某核电厂热态功能试验中,巡视发现主回路的某滞流分支管振动超标。根据实测振动随温度变化的趋势、管道固有声模态分析和模态分析等,推测管道内流体的声振动激励引发管道共振。根据滞流管三通处流体的漩涡脱落频率计算和声振动频率计算,推测漩涡脱落与滞流管内流体的固有声振动频率锁定,引发声振动激励放大。综合分析计算和实测结果,确定滞流管振动超标的原因为流声固耦合振动。对管道支架进行了优化,以错开声固耦合共振频率,在三通处倒圆角削弱漩涡脱落,以降低流声耦合的声振动幅值。优化后的分支管振动会明显降低,以保证承压边界的安全。     

基于临近差分曲率差值指标的简支梁损伤识别方法

为方便有效地进行简支梁的损伤识别,基于对称集中加载和结构静力位移数据的采集,以梁体的局部抗弯刚度和剪切刚度为损伤识别参数,通过理论推导提出了一个基于中心差分曲率指标的损伤识别新指标——临近差分曲率差值Di(difference of nearby difference curvature,DNDC),并建立了相应的损伤...