Synthesis and characterization of cyclic pseudopeptide libraries containing thiomethylene and thiomethylene-sulfoxide amide bond surrogates

Resistance-modifying agents (RMAs) such as Verapamil have been proved to be effective in reversing multi-drug resistance (MDR) in many in vitro assays. In this study we have investigated the efficacy of Dex-Verapamil, the R-isomer of Verapamil, as a chemosensitizer in a murine leukemia cell line (P388) and in its resistant counterpart (P388/Dx) expressing a typical MDR phenotype. We have examined in vivo the effect of the co-administration of Dex-Verapamil and Doxorubicin in mice transplanted with P388 or P388/Dx cells. Mice treated with the combination of Doxorubicin plus RMA had a significant increase in survival rate as compared to controls; however, the effect was modest. On the contrary, in vitro Dex-Verapamil can enhance Doxorubicin cytotoxicity in P388/Dx cells with a much greater effect depending on the treatment scheme used, by increasing the intracellular content of drug. Taken together our data indicate that Dex-Verapamil can indeed increase the sensitivity to Doxorubicin in resistant cells, but the limited efficacy shown in vivo demonstrates that this phenomenon is strongly dependent on the treatment scheme used and on the maintenance of constantly elevated serum levels.     

2005，十大危险入侵主妇厨房

食品安全．在2005年中仍然纷纷扰扰：食品与家庭每个成员的健康息息相关，而维护全家人的健康，则是女主人义不容辞的责任。我们一起来听听．于她们而言．2005年最关心的食品安全问题是什么？[编者按]     

如何辨别电影画原底片的优劣

本文提供一个简便实用的质量鉴定方法,用于在制作发行拷贝前,辨别电影画原底片的优劣。     

Study on phase behavior–impact strength relationship of unsaturated polyester/polyurethane hybrid polymer network

The phase behavior of a hybrid polymer network (HPN) composed of poly[(propylene glycol maleate)-co-(propylene glycol phthalate)] crosslinked with styrene and polyester–urethane crosslinked with methylene-bis-ortho-chloroaniline was examined. The correlation between phase separation and impact strength of the HPNs is discussed. The composition of HPNs has an effect on their properties.     

70推土机主离合器分离杆螺栓失效分析

主离合器分离杆螺栓是一个重要安全件，使用中经常发生断裂。经过失效分析确定断裂原因是由其配件引起。提高配件的冷加工质量及改进结构，可解决分离杆螺栓的断裂问题。     

大力发展循环经济实现企业可持续发展

莱钢始建于1970年1月,现控股莱钢股份、鲁银投资两个上市公司及齐鲁证券等25个子公司。莱钢是中国冶金行业首批通过ISO9002质量管理体系、ISO14001环境管理体系和OHSAS18001职业安全健康管理体系国家认证的企业。2005年,莱钢被国家发改委确定为国家第一批循环经济试点单位。     

基于IPv6校园网的智能选课系统的J2EE架构的设计与实现

通过分析IPv6校园网自主学习模式下的自主选课问题,提出了利用J2EE技术构建基于IPv6校园网的智能选课系统的总体结构及具体实现.     

＇06香港专利授权展规模创历年之最

第五届香港专利授权展7月4日至6日在香港会展中心2B展馆举行。本届专利授权展参展商逾百家，将展示更多的授权项目，举办内容丰富的研讨会，参观者不仅可以从展会中寻找商机。而且可以获得新的信息，从中窥测到专利授权的市场走向。[编者按]