iRGD-reinforced,photo-transformable nanoclusters toward cooperative enhancement of intratumoral penetration and antitumor efficacy

Nano Research - Insufficient intratumoral penetration greatly hurdles the anticancer performance of nanomedicine. To realize highly efficient tumor penetration in a precisely and spatiotemporally...     

Blocked crystallization in capped ultrathin polymer films studied by molecular simulations

The crystallization of capped ultrathin polymer films is closely dependent on film thickness and interfacial interaction. Using dynamic Monte Carlo simulations, the crystallization behaviors of polymer films confined between two substrates were investigated. The crystallization rate of confined polymers is reduced with high interfacial interactions. Above a critical strength of interfacial interaction, polymer crystallization in the thin film is inhibited within the simulation time scales. An increase in film thickness leads to a rise in critical interfacial interaction. In thicker films, the chains have more space to change conformation to form crystal stems. In addition, there are fewer absorbed segments in confined chains for the thicker films, and thus the chains have stronger ability to adjust their conformation. Therefore an increase in film thickness can cause a reduction in the entropic barrier required for the formation of crystals and thus an increase in the critical interfacial interaction. © 2018 Society of Chemical Industry     

极限工况下的管网“互联互通”改进方案

在全国天然气管道“主干互联、区域成网”(以下简称“互联互通”)基础格局逐渐形成的背景下,天然气管网规模日益扩大、管道分支和气源增加,并且分布不集中、输送方向可变,使得输气方案更加灵活,可以更好地解决某些地域的供气紧张问题;但受现有站场和设备的限制,暂不能满足某些多线组合极限工况,使得“互联互通”的初衷难以全部实现。为了使得现有的各输气干线在实现“互联互通”之后可以满足更多的多线组合工况,在分析“互联互通”背景下M管网工况变化的基础上,研发了可以进行水力仿真和压气站方案制订的计算软件,并对3种极限工况下的不同输气量情况进行了可行性试算,进而基于试算结果提出了相应的管网改进建议。研究结果表明:(1)经验证,软件计算误差满足要求;(2)在M管道某处增设压气站或在某些输气站场配置压缩机组;(3) M管网改进调整后,可以完成大部分的多线组合极限工况,真正实现“互联互通”的输气方案。结论认为,该研究成果有助于推进全国天然气管网早日实现“互联互通”。     

On the modeling of bending responses of graphene-reinforced higher order annular plate via two-dimensional continuum mechanics approach

This research presents bending responses of FG-GPLRC plates based upon higher order shear deformation theory (HSDT) for various sets of boundary conditions. The rule of the mixture and modified Halpin–Tsai model are engaged to provide the effective material constant of the composite layers. By employing Hamilton’s principle, the governing equations of the structure are derived and solved with the aid of the differential quadrature method (DQM). Afterward, a parametric study is done to present the effects of three kinds of FG patterns, weight fraction of the GPLs, radius ratio, and thickness to inner radius ratio on the bending characteristics of the FG-GPLRC disk. Numerical results reveal that in the initial value of the \(Zt/h\), using more GPLs for reinforcing the structure provides an increase in the normal stresses but this matter is inverse for the higher value of the \(Zt/h\). The results show that considering the smaller radius ratio is a reason for boosting the shear stresses of the structure for each \(Zt/h\). Another consequence is that for the negative value of \(Zt/h\), it is true that by increasing \(h/{R}_{i}\) , the normal stresses increases but if there is positive value for \(Zt/h\), the radial and circumferential stresses fall down by having an increase in the \(h/{R}_{i}\).

     

济阳坳陷下古生界潜山油气藏特征及成藏模式

济阳坳陷下古生界潜山具有多样性、复杂性的特点，潜山差异性的形成演化、油气成藏主控因素和控藏模式不明确，严重制约了该区潜山油气勘探。在潜山分类的基础上，综合利用系统恢复、分类对比和典型解剖等方法，揭示了济阳坳陷下古生界不同类型潜山的形成演化过程和油气成藏主控因素差异性，分类建立了油气成藏模式。研究表明，济阳坳陷下古生界主要发育高位新盖侵蚀残丘潜山、中位古盖拉张断块潜山、中位新古盖拉张剪切断块潜山、中位中古盖挤压拉张断块潜山和低位古盖拉张滑脱断块潜山5种潜山类型。不同类型潜山的形成演化和油气成藏各具特色，其中，高位新盖侵蚀残丘潜山的发育受隆升、侵蚀作用控制，油气成藏主要受控于油源和盖层条件，表现为"单向供烃、砂体-不整合岩溶体联合输导、残丘控藏"的成藏模式；中位古盖拉张断块潜山的发育受掀斜、断裂作用控制，油气成藏主要受控于储集条件，表现为"单向供烃、顺向断层输导、反向断层控藏"的成藏模式；中位新古盖拉张剪切断块潜山的发育受反转、翘倾和走滑切割作用控制，油气成藏主要受控于输导条件，表现为"多源供烃、断溶体立体输导、断裂控藏"的成藏模式；中位中古盖挤压拉张断块潜山的形成受强烈挤压、拉张滑脱作用控制，油气成藏主要受控于储集条件，表现为"多源供烃、断缝体输导、断褶控藏"的成藏模式；低位古盖拉张滑脱断块潜山的形成受强烈拉张滑脱作用控制，油气成藏主要受控于输导条件，表现为"顶部供烃、断缝体输导、断裂控藏"的成藏模式。     

独立学院《环境监测实验》课程教学改革

从独立学院"应用型专业人才"的培养目标出发,结合我院近年来开展《环境监测实验》课程积累的经验,对本实验课程的教学内容、教学方法和课程评价体系等进行了改革。强调理论与实验内容有机结合,通过激发学生的学习兴趣,提高学生的实践应用能力,以满足社会对环境科学与工程专业应用型专业人才的需求。     

AutoCAD、StruCAD 3D及SolidWorks软件在石油井架、底座强度校核中的应用

分别使用AutoCAD、StruCAD 3D及Solid Works软件在石油井架、底座校核中进行强度分析,AutoCAD软件的主要优势在工程制图领域,兼具强度分析功能,适用于单个形状比较规则的型材强度分析;StruCAD 3D是专门针对大型钢结构进行强度校核的分析软件,具有强大的计算处理功能,兼具风载处理能力,在处理大型、复杂结构的时候应优先考虑应用该软件;当遇到需要进行实体造型、模拟实际情况进行校核时,SolidWorks软件较为方便,可以直观地看到应变情况。     

On the local behavior of spaces of range image patches

We focus on the quantitative and local topological properties of range images. We consider the spaces M_m of m × m high-contrast patches of range images for m=?3, 5, 7, 9, 11. Using computational topological tools to analyze range image patches, we detect that M₃ (M₉, M₁₁) has core subsets with the topology of a circle, M₃, M₅, M₇, M₉ and that M₁₁ have some subspaces with the topology of a Klein bottle. We also discover that the largest subspace with the Klein bottle’s topology decreases as the measurements of patches increase, which generalizes the results in the paper of H. Adams and G. Carlsson, and demonstrates properties among optical images and range image patches, which are more similar than those established by Lee et al.

     

In vivo Kinetic Biodistribution of Nano‐Sized Outer Membrane Vesicles Derived from Bacteria

Evaluation of kinetic distribution and behaviors of nanoparticles in vivo provides crucial clues into their roles in living organisms. Extracellular vesicles are evolutionary conserved nanoparticles, known to play important biological functions in intercellular, inter‐species, and inter‐kingdom communication. In this study, the first kinetic analysis of the biodistribution of outer membrane vesicles (OMVs)—bacterial extracellular vesicles—with immune‐modulatory functions is performed. OMVs, injected intraperitoneally, spread to the whole mouse body and accumulate in the liver, lung, spleen, and kidney within 3 h of administration. As an early systemic inflammation response, increased levels of TNF‐α and IL‐6 are observed in serum and bronchoalveolar lavage fluid. In addition, the number of leukocytes and platelets in the blood is decreased. OMVs and cytokine concentrations, as well as body temperature are gradually decreased 6 h after OMV injection, in concomitance with the formation of eye exudates, and of an increase in ICAM‐1 levels in the lung. Following OMV elimination, most of the inflammatory signs are reverted, 12 h post‐injection. However, leukocytes in bronchoalveolar lavage fluid are increased as a late reaction. Taken together, these results suggest that OMVs are effective mediators of long distance communication in vivo.     

生产过程质量不合格品系统(IQS)方案建模及优化

针对不合格品的高效处置、数据的有效分析对企业质量控制具有深远的意义,其是装备制造领域质量管理研究的重点。文章以SAP接口二次开发、IQS流程建模、数据库建立、系统实用价值等方面展开详细论述,确保质量信息可追溯分析。