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181.
Investors in futures market used to employ trading system which depends on reference pattern (template) to detect real-time buy or sell signal from the market. Indeed they prepare in advance a number of reference patterns that market movement might follow, and then match the current market with one of reference patterns. One popular way to prepare templates is to fix a relatively small number of them which represent possible market movements efficiently. The underlying assumption of this approach is of course that the current market movement is close enough to one of the templates. However, there is always a calculated risk that the current market is close to none of them sufficiently. In this article we investigate the issue of appropriate number of templates (or template cardinality I) in terms of profitability. We will show that one may improve profitability by increasing I and that random pattern sampling plays a key role in such case. An empirical study is done on the Korean futures market.  相似文献   
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Food Science and Biotechnology - Polyphenols are secondary metabolites produced in higher plants. They are known to possess various functional properties in the human body. Polyphenols also exhibit...  相似文献   
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Food Science and Biotechnology - This study was conducted to compare the growth parameters of Listeria monocytogenes between beef isolates and Type strains in raw beef. Beef was artificially...  相似文献   
184.
A quality-by-design approach was adopted to develop telmisartan potassium (TP) tablets, which were bioequivalent with the commercially available Micardis® (telmisartan free base) tablets. The dissolution pattern and impurity profile of TP tablets differed from those of Micardis® tablets because telmisartan free base is poorly soluble in water. After identifying the quality target product profile and critical quality attributes (CQAs), drug dissolution, and impurities were predicted to be risky CQAs. To determine the exact range and cause of risks, we used the risk assessment (RA) tools, preliminary hazard analysis and failure mode and effect analysis to determine the parameters affecting drug dissolution, impurities, and formulation. The range of the design space was optimized using the face-centered central composite design among the design of experiment (DOE) methods. The binder, disintegrant, and kneading time in the wet granulation were identified as X values affecting Y values (disintegration, hardness, friability, dissolution, and impurities). After determining the design space with the desired Y values, the TP tablets were formulated and their dissolution pattern was compared with that of the reference tablet. The selected TP tablet formulated using design space showed a similar dissolution to that of Micardis® tablets at pH 7.5. The QbD approach TP tablet was bioequivalent to Micardis® tablets in beagle dogs.  相似文献   
185.
Information Systems and e-Business Management - Mobile commerce, or m-commerce, has quickly become a powerful, indispensable approach for diverse business to consumer (B2C) industries to secure...  相似文献   
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