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21.
Takuo Suganuma SungDoke Lee Tetsuo Kinoshita Norio Shiratori 《New Generation Computing》2001,19(2):173-191
In this paper, we propose an agent architecture to improve flexibility of a videoconference system with strategy-centric adaptive
QoS (Quality of Service) control mechanism. The proposed architecture realizes more flexibility by changing their QoS control
strategies dynamically. To switch the strategies, system considers the properties of problems occurred on QoS and status of
problem solving process. This architecture is introduced as a part of knowledge base of agent that deals with cooperation
between software module of videoconference systems. We have implemented the mechanism, and our prototype system shows its
capability of flexible problem solving against the QoS degradation, along with other possible problems within the given time
limitation. Thus we confirmed that the proposed architecture can improve its flexibility of a videoconference system compared
to traditional systems.
Takuo Suganuma, Dr.Eng.: He is a research associate of Research Institute of Electrical Communication of Tohoku University. He received a Dr.Eng.
degree from Chiba Institute of Technology in 1997. His research interests include agent-based computing and design methodology
for distributed systems. He is a member of IPSJ, IEICE and IEEE.
SungDoke Lee: He is a Ph.D. Student in the Graduate School of Information Sciences in Tohoku University. He received his MEng degree at
Chonbuk National University, Korea in 1991. His research interests include Flexible Network and Knowledge of Agent.
Tetsuo Kinoshita, Dr.Eng.: He is an associate professor of Research Institute of Electrical Communication of Tohoku University. He received a Dr.Eng.
degree in information engineering from Tohoku University, Japan. His research interests include knowledge engineering, cooperative
distributed processing and agent-based computing. He received the the IPSJ Best Paper Award in 1997, etc. He is a member of
IPSJ, IEICE, JSAI, AAAI, ACM and IEEE.
Norio Shiratori, Dr.Eng.: After receiving his Dr.Eng degree at Tohoku University, he joined the Research Institute of Electrical Communication of
Tohoku University in 1977, and is now a professor at the same University. He has been engaged in research on distributed processing
system, and flexible intelligent network. He received the 25th Anniversary of IPSJ Memorial Prize-Winning Paper Award in 1985,
the 6th Telecommunications Advancement Foundation Incorporation Award in 1991, the Best Paper Award of ICOIN-9 in 1994, the
IPSJ Best Paper Award in 1997, etc. He has been named a Fellow of the IEEE for his contributions to the field of computer
communication networks. 相似文献
22.
Seiichi Kawahara Nurul Hayati Yusof Kenshi Noguchi Kenichiro Kosugi Yoshimasa Yamamoto 《Polymer》2014
The outstanding mechanical properties of soft materials i.e. natural rubber are partly due to the organic–inorganic nanomatrix structure because numerous organic microparticles are dispersed in a small amount of an inorganic nanomatrix composed of inorganic nanoparticles and organic macromolecules. Here we form an organic–inorganic nanomatrix using graft-copolymerization of a vinyl monomer with an inorganic oxide precursor onto natural rubber particles with an average diameter of 1 μm dispersed in water. The inorganic oxide precursor is converted into inorganic oxide nanoparticles through hydrolysis and condensation, forming chemical linkages between natural rubber microparticles and inorganic oxide nanoparticles. Transmission electron microscopy indicates that the organic–inorganic nanomatrix is densely filled with inorganic oxide nanoparticles and the natural rubber microparticles are dispersed in the nanomatrix. This nanomatrix composite realizes both energetic elasticity and entropic elasticity of a soft material, opening a novel field of building block chemistry with respect to a pair of organic microparticles and inorganic nanoparticles. 相似文献
23.
Shinji Yamashita Susumu Kanno Ayako Honjo Yurika Otoki Kiyotaka Nakagawa Mikio Kinoshita Teruo Miyazawa 《Lipids》2016,51(2):199-210
Ethanolamine plasmalogen (PlsEtn), which is present at high levels in brains, is believed to be involved in neuronal protection. The present study was performed to search for PlsEtn resources in foodstuffs. The foodstuffs examined showed a wide range of PlsEtn contents from 5 to 549 μmol/100 g wet wt. The marine invertebrates, blue mussel, and ascidian had high PlsEtn contents (over 200 μmol/100 g wet wt). Profiling of the molecular species showed that the predominant fatty acids of PlsEtn species were 20:5 (EPA) and 22:6 (DHA) at the sn‐2 position of the glycerol moiety in marine foodstuffs, whereas major PlsEtn species in land foodstuffs were 20:4. Following quantitative analysis by multiple reaction monitoring, the ascidian viscera were shown to contain the highest levels of 18:0/20:5‐PlsEtn and 18:0/22:6‐PlsEtn (86 and 68 μmol/100 g wet wt, respectively). In order to evaluate a neuronal antiapoptotic effect of these PlsEtn species, human neuroblastoma SH‐SY5Y cells were treated with ethanolamine glycerophospholipid (EtnGpl), purified from the ascidian viscera, under serum starvation conditions. Extrinsic EtnGpl from ascidian viscera showed stronger suppression of cell death induced by serum starvation than with bovine brain EtnGpl. The EtnGpl from ascidian viscera strongly suppressed the activation of caspase 3. These results suggest that PlsEtn, especially that containing EPA and DHA, from marine foodstuffs is potentially useful for a therapeutic dietary supplement preventing neurodegenerative diseases, such as Alzheimer's disease (AD). 相似文献
24.
A. Nakano T. Shimazaki M. Sekiya H. Shiozawa K. Ohtsuka A. Aoyagi T. Iwakiri Z. Mikami M. Sato Y. Sugino K. Kinoshita T. Matsuoka T. Imamura Y. Takayama K. Yamamoto 《International Journal of Hydrogen Energy》2021,46(29):15649-15659
Monitoring the temperature in liquid hydrogen (LH2) storage tanks on ships is important for the safety of maritime navigation. In addition, accurate temperature measurement is also required for commercial transactions. Temperature and pressure define the density of liquid hydrogen, which is directly linked to trading interests. In this study, we developed and tested a liquid hydrogen temperature monitoring system that uses platinum resistance sensors with a nominal electrical resistance of approximately 1000 Ω at room temperature, PT-1000, for marine applications. The temperature measurements were carried out using a newly developed temperature monitoring system under different pressure conditions. The measured values are compared with a calibrated reference PT-1000 resistance thermometer. We confirm a measurement accuracy of ±50 mK in a pressure range of 0.1 MPa–0.5 MPa. 相似文献
25.
26.
H. Serizawa K. Nakajima Y. Arai T. Yamashita K. Kuramoto H. Kinoshita S. Yamanaka M. Uno K. Kurosaki 《Progress in Nuclear Energy》2001,38(3-4):237-240
The phase relationship between ZrO2 and PuO2 was examined in a low PuO2 content region, from 3.1 to 11.2 mol% PuO2, at temperatures between 1273 K and 1473 K, by high temperature X-ray diffractometry. The measurements were carried out in air. At 1273 K, the samples in this composition range consisted of two phases, monoclinic and cubic. Another phase, tetragonal, was observed at 1373 K. The low temperature monoclinic phase disappeared at 1473 K. It was confirmed that the monoclinic phase disappears around 1463 K; the disappearance temperature does not depend on the composition of the sample. It was, thus, inferred that there should be a eutectoid line in the phase diagram. Though the eutectoid point is not clear, the PuO2 content at the point should be less than 3.1 mol%. 相似文献
27.
Kazuo Tsubota Stephen C. Pflugfelder Zuguo Liu Christophe Baudouin Hyo Myung Kim Elisabeth M. Messmer Friedrich Kruse Lingyi Liang Jimena Tatiana Carreno-Galeano Maurizio Rolando Norihiko Yokoi Shigeru Kinoshita Reza Dana 《International journal of molecular sciences》2020,21(23)
Over the past decades, the number of patients with dry eye disease (DED) has increased dramatically. The incidence of DED is higher in Asia than in Europe and North America, suggesting the involvement of cultural or racial factors in DED etiology. Although many definitions of DED have been used, discrepancies exist between the various definitions of dry eye disease (DED) used across the globe. This article presents a clinical consensus on the definition of DED, as formulated in four meetings with global DED experts. The proposed new definition is as follows: “Dry eye is a multifactorial disease characterized by a persistently unstable and/or deficient tear film (TF) causing discomfort and/or visual impairment, accompanied by variable degrees of ocular surface epitheliopathy, inflammation and neurosensory abnormalities.” The key criteria for the diagnosis of DED are unstable TF, inflammation, ocular discomfort and visual impairment. This definition also recommends the assessment of ocular surface epitheliopathy and neurosensory abnormalities in each patient with suspected DED. It is easily applicable in clinical practice and should help practitioners diagnose DED consistently. This consensus definition of DED should also help to guide research and clinical trials that, to date, have been hampered by the lack of an established surrogate endpoint. 相似文献
28.
Sachi Oshima Shunichi Asai Naohiko Seki Chikashi Minemura Takashi Kinoshita Yusuke Goto Naoko Kikkawa Shogo Moriya Atsushi Kasamatsu Toyoyuki Hanazawa Katsuhiro Uzawa 《International journal of molecular sciences》2021,22(12)
We identified the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) tissues by RNA sequencing, in which 168 miRNAs were significantly upregulated, including both strands of the miR-31 duplex (miR-31-5p and miR-31-3p). The aims of this study were to identify networks of tumor suppressor genes regulated by miR-31-5p and miR-31-3p in HNSCC cells. Our functional assays showed that inhibition of miR-31-5p and miR-31-3p attenuated cancer cell malignant phenotypes (cell proliferation, migration, and invasion), suggesting that they had oncogenic potential in HNSCC cells. Our in silico analysis revealed 146 genes regulated by miR-31 in HNSCC cells. Among these targets, the low expression of seven genes (miR-31-5p targets: CACNB2 and IL34; miR-31-3p targets: CGNL1, CNTN3, GAS7, HOPX, and PBX1) was closely associated with poor prognosis in HNSCC. According to multivariate Cox regression analyses, the expression levels of five of those genes (CACNB2: p = 0.0189; IL34: p = 0.0425; CGNL1: p = 0.0014; CNTN3: p = 0.0304; and GAS7: p = 0.0412) were independent prognostic factors in patients with HNSCC. Our miRNA signature and miRNA-based approach will provide new insights into the molecular pathogenesis of HNSCC. 相似文献
29.
Ueda S Kinoshita M Tanaka F Tsuboi M Shimizu S Oohata N Hino M Yamada M Isogai Y Hashimoto S 《Journal of Bioscience and Bioengineering》2011,112(4):409-414
Micafungin (FK463) is a widely used treatment for life-threatening, deep-seated fungal infections. It is an echinocandin-like lipopeptide derived from the chemical modification of deacylated FR901379, a type of lipopeptide antibiotic produced by Coleophoma empetri F-11899. The palmitoyl moiety of FR901379 is deacylated by FR901379 acylase produced by Streptomyces sp. no. 6907. In this study, our goal was to generate an improved strain of Streptomyces sp. no. 6907 capable of hyperproducing the FR901379-acylase enzyme. To accomplish this goal, modified strains of Streptomyces sp. no. 6907 were generated using UV-irradiation mutagenesis, and strain selection was performed using an agar-plate screening method to efficiently select an acylase-hyperproducing strain. Three marker indices were shown to correlate with elevated acylase production: decreased candidacidal activity of FR901379, decreased proteolytic activity on skim milk, and phenotypic characteristics. Cloning and subsequent sequencing of the acylase gene from the hyperproducing mutant revealed no mutations in either the acylase structural gene or the 5'-flanking region required for gene expression. The growth medium was also modified to maximize acylase production. We successfully increased acylase activity approximately 65-fold, compared with the original growth conditions (wild strain cultured in the original unmodified medium). To minimize formation of excess foam during the fermentation process, we optimized the parameters of agitation speed, as calculated from the discharge flow rate. Using our improved strain and the optimized medium and growth conditions, we have developed an improved and highly reproducible method for stable large-scale production of FR901379-acylase. 相似文献
30.
Kimiaki Tsutsui Hiroaki Yoshimizu Yoshiharu Tsujita Takatoshi Kinoshita 《应用聚合物科学杂志》1999,73(13):2733-2738
The permeability coefficients of O2, N2, and CO2 gases at 25°C were examined for composite membranes that were prepared by filling poly(ethylene oxide)(PEO) with different molecular weights into a porous membrane. The permeability coefficients of O2, N2, and CO2 were 2 × 10−10 – 4 × 10−10, 5 × 10−11 – 9.5 × 10−11, and 6 × 10−10 – 1 × 10−9 (cm3 STPcm/cm2 s cmHg), respectively. The higher permeability coefficients of CO2 are explained in terms of high solubility of CO2 in filled PEO. The permeability coefficient of CO2 was affected by the degree of crystallinity of PEO in the composite. On the other hand, there was little effect of crystallinity on O2 and N2 permeability coefficients. Some probable relationships between selectivities of O2 to N2 and CO2 to N2 and the degree of crystallinity of PEO were observed. The CO2 gas permeability coefficients of the composite membrane for PEO50000 (Mw = 5 × 104) showed a marked change due to melting or crystallization of PEO. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 73: 2733–2738, 1999 相似文献