A Multivariate T2 Control Chart for Skewed Populations Using Weighted Standard Deviations

This paper proposes a heuristic method of constructing multivariate T² control charts for skewed populations based on ‘weighted standard deviations’, obtained by decomposing the standard deviation into upper and lower deviations according to the direction and degree of skewness. The proposed method adjusts the variance–covariance matrix of quality characteristics and modifies the ellipsoidal probability density function contour of the multivariate normal distribution to a shape similar to that of the skewed distribution. False alarm rates and out‐of‐control average run lengths of the proposed control chart are compared with those of the standard control chart for multivariate lognormal, Weibull and gamma distributions, and the results show that considerable improvement over the standard method can be achieved when the distribution is skewed. Copyright © 2003 John Wiley & Sons, Ltd.     

Preparation of AZ91D Slurries for Semi-Solid Forming Using Al8 ( Mn, Fe) 5 Precipitates

During the solidification of the AZ91D-alloys, the Al8(Mn, Fe)5 phase is generally precipitated in the melt in advance of the precipitation of the primary α-Mg. The basic principle for manufacturing AZ91D-alloy slurries for semi solid forming is to use the Al8(Mn, Fe)5 precipitates as the heterogeneous nucleation sites for primary α-Mg phases. Microscopic analysis for the location of the Al8(Mn, Fe)5 precipitate explains that the Al8(Mn, Fe)5 precipitate is the effective heterogeneous nucleation site for the primary α-Mg phase. It was also observed that increase of the Mn content in the melt and the cooling rate below to the solid/liquid two-phase region resulted in smaller and more globular primary α-Mg due to the increase of heterogeneous nucleation sites. It was found that the average α-Mg diameter grew as a function of t0.278, where t is the holding time at the solid/liquid two-phase region. This would be attributed to the Ostwald type ripening and coalescence between primary α-Mg phases. The cooling rate below to the solid/liquid two-phase region, Mn content in AZ91D alloy, and the holding time and temperature affected on the quality of slurry.     

The effects of refractive index heterogeneity within kidney tissue on multiphoton fluorescence excitation microscopy

Although multiphoton fluorescence excitation microscopy has improved the depth at which useful fluorescence images can be collected in biological tissues, the reach of multiphoton fluorescence excitation microscopy is nonetheless limited by tissue scattering and spherical aberration. Scattering can be reduced in fixed samples by mounting in a medium whose refractive index closely matches that of the fixed material. Using optical 'clearing', the effects of refractive index heterogeneity on signal attenuation with depth are investigated. Quantitative measurements show that by mounting kidney tissue in a high refractive index medium, less than 50% of signal attenuates in 100 μm of depth.     

In Vitro hydrodynamic evaluation of prosthetic polymer heart valves in steady flow

Hydrodynamic comparison of two polymer valves with two mechanical valves is presented. The valves were perfused in a steady flow system, and comparisons between the valves were made on the transvalvular pressure distribution and drop, opening area, and leakage volume. Particular emphasis was placed on a slit-type bileaflet polymer valve which was newly designed and fabricated in our research group. The results showed that the functional characteristics of a slit-type bileaflet polymer valve compared favorably with that of mechanical valves. This valve may be a viable and inexpensive alternative, especially for short-term use in TAH or VAD systems.     

Shear horizontal wave transduction in plates by magnetostrictive gratings

Shear horizontal waves are very useful in nondestructive evaluation applications because of their non-dispersive property. The objective of this research is to investigate frequency-tuned shear horizontal wave transduction in plates by using magnetostrictive nickel gratings. Since wireless energy conversion between magnetic energy and acoustic energy in magnetostrictive material can take place, the generation and measurement of waves by the magnetostrictive principle have recently received much attention. In this work, a grating-type magnetostrictive transducer was considered for SH wave transduction; waves can be effectively tuned at desired frequencies by changing grating size and distance. The present experiments showed that the bias field strength and grating width should be selected appropriately to avoid generating unwanted wave modes such as the S0-Lamb wave modes. It is also confirmed from experiments that the grating distance controls the center (or tuning) frequency of the grating transducer.     

Ultra-precision lapping of machinable ceramic Si3N4-BN by in-process electrolytic dressing

The machinable ceramic Si₃N₄-BN is a material which is increasingly being employed for automobile bearings and machinable ceramics. This material is very hard and has high resistance against volatile temperature and wear. It's efficient quality and accurate surfaces have always been of high demand for many applications in the industrial field. Besides, this material is varied by the percentage of BN contained in it, and the characteristics of lapping also varies according to this percentage of BN. Hence, in-process electrolytic dressing for ultra-precision lapping was introduced and used to experiment with the differing BN percentages in machinable ceramic Si₃ N₄. Metal-bonded super-abrasive diamond lapping wheels have superior qualities such as high bond strength, high stability and high machinability. The major problems encountered are wheel loading and glazing, which impedes the effectiveness of the cast-iron bonded diamond lapping wheel and, therefore, dressing should be considered. In this respect, in-process electrolytic dressing (IED) is proposed as an effective method regarding continuous protruding abrasives on the surface of wheels, whereby loading and glazing phenomena can apparently disappear. In this paper, the machining characteristics of machinable ceramic Si₃N₄-BN have been studied by adapting the IED lapping process in terms of the percentage of h-BN material.     

Selective Coloration of Melanin Nanospheres through Resonant Mie Scattering

Black melanin inks are prepared to selectively exhibit colors under strong light, inspired by human hair. High absorbance of melanin suppresses multiple scattering, causing resonant Mie scattering predominant. Various colors can be developed as the resonant wavelength dictated by nanosphere diameter. Therefore, the melanin inks can be used to encrypt and selectively disclose multicolor patterns for anticounterfeiting applications.     

Genipin,an Inhibitor of UCP2 as a Promising New Anticancer Agent: A Review of the Literature

Genipin is a protein cross-linking agent extracted from Gardenia (Gardenia jasminoides Ellis) fruits. This fruit has conventionally been used as a Chinese herbal medicine for the treatment of inflammation and jaundice and as an edible colorant in oriental countries. Uncoupling protein (UCP)-2 is a member of the family of uncoupling proteins, which are anion transporters positioned in the mitochondrial inner membrane. Genipin has been shown to have hepatoprotective activity, acting as an effective antioxidant and inhibitor of mitochondrial UCP2, and is also reported to exert significant anticancer effects. In this review, the author presents the latest progress of genipin as an anticancer agent and concisely describes its various mechanisms of action. In brief, genipin inhibits UCP2 to attenuate generation of reactive oxygen species (ROS), leading to ROS/c-Jun N-terminal kinase-dependent apoptosis of cancer cells. Genipin also increases the tissue inhibitors of matrix metalloproteases (MMP)-2, a kind of tumor promoter in a variety of cancers, as well as induces caspase-dependent apoptosis in in vitro and in vivo models. These findings suggest that genipin can serve as a promising novel antitumor agent that could be applicable for chemotherapy and/or chemoprevention for cancers.     

Trans-Reduction of Cerebral Small Vessel Disease Proteins by Notch-Derived EGF-like Sequences

Cysteine oxidation states of extracellular proteins participate in functional regulation and in disease pathophysiology. In the most common inherited dementia, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), mutations in NOTCH3 that alter extracellular cysteine number have implicated NOTCH3 cysteine states as potential triggers of cerebral vascular smooth muscle cytopathology. In this report, we describe a novel property of the second EGF-like domain of NOTCH3: its capacity to alter the cysteine redox state of the NOTCH3 ectodomain. Synthetic peptides corresponding to this sequence (NOTCH3 N-terminal fragment 2, NTF2) readily reduce NOTCH3 N-terminal ectodomain polypeptides in a dose- and time-dependent fashion. Furthermore, NTF2 preferentially reduces regional domains of NOTCH3 with the highest intensity against EGF-like domains 12–15. This process requires cysteine residues of NTF2 and is also capable of targeting selected extracellular proteins that include TSP2 and CTSH. CADASIL mutations in NOTCH3 increase susceptibility to NTF2-facilitated reduction and to trans-reduction by NOTCH3 produced in cells. Moreover, NTF2 forms complexes with the NOTCH3 ectodomain, and cleaved NOTCH3 co-localizes with the NOTCH3 ectodomain in cerebral arteries of CADASIL patients. The potential for NTF2 to reduce vascular proteins and the enhanced preference for it to trans-reduce mutant NOTCH3 implicate a role for protein trans-reduction in cerebrovascular pathological states such as CADASIL.