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231.
232.
Kazuma Sakamoto Tomoya Ozaki Yuji Suzuki Kenji Kadomatsu 《International journal of molecular sciences》2021,22(11)
Type IIa receptor tyrosine phosphatases (RPTPs) play pivotal roles in neuronal network formation. It is emerging that the interactions of RPTPs with glycans, i.e., chondroitin sulfate (CS) and heparan sulfate (HS), are critical for their functions. We highlight here the significance of these interactions in axon regeneration and synaptogenesis. For example, PTPσ, a member of type IIa RPTPs, on axon terminals is monomerized and activated by the extracellular CS deposited in neural injuries, dephosphorylates cortactin, disrupts autophagy flux, and consequently inhibits axon regeneration. In contrast, HS induces PTPσ oligomerization, suppresses PTPσ phosphatase activity, and promotes axon regeneration. PTPσ also serves as an organizer of excitatory synapses. PTPσ and neurexin bind one another on presynapses and further bind to postsynaptic leucine-rich repeat transmembrane protein 4 (LRRTM4). Neurexin is now known as a heparan sulfate proteoglycan (HSPG), and its HS is essential for the binding between these three molecules. Another HSPG, glypican 4, binds to presynaptic PTPσ and postsynaptic LRRTM4 in an HS-dependent manner. Type IIa RPTPs are also involved in the formation of excitatory and inhibitory synapses by heterophilic binding to a variety of postsynaptic partners. We also discuss the important issue of possible mechanisms coordinating axon extension and synapse formation. 相似文献
233.
Yuji Yabuki Yoshitaka Mukaida Yoshinori Saito Kazunori Oshima Tatsuo Takahashi Eiichi Muroi Kei Hashimoto Yasushi Uda 《Food chemistry》2010
To characterise the composition of sulphur-containing constituents in Chinese chive (Allium tuberosum Rottler), GC–MS and HPLC analyses were carried out, using 12 varieties of Chinese origin, 4 varieties of Japanese origin and 6 commercially available cultivars. Five disulphides (dimethyl, allyl methyl, methyl 1-(E)-propenyl, diallyl, and allyl 1-(E)-propenyl), two trisulphides (dimethyl and allyl methyl), and two vinyldithiins (3-vinyl-[4H]-1,2- and 2-vinyl-[4H]-1,3-) were identified on the basis of their mass spectral and GC-retention data. Among the detected sulphur compounds, sulphides with a methyl group predominated over those with an allyl group. This was supported by the HPLC estimations, suggesting that all cultivars examined had much greater amounts of methiin than alliin. Also, two novel compounds were tentatively identified as [3H,4H]-1,2-dithiin and [2H,4H]-1,3-dithiin on the basis of their mass spectral features, GC-retention data, and some experimental results on their formation in reaction mixtures with different proportions of methiin and alliin. Their formation mechanism was proposed. 相似文献
234.
文章探讨了用工业氯化钙和纯碱制备球状碳酸钙的适宜工艺 ,通过正交实验 ,研究了反应温度、溶液浓度等因素对产品的影响 ,并得到了实验条件的最优组合 ,得到了球状碳酸钙。研究结果表明 :加入反应缓冲剂及结晶生长停止剂是合成球状碳酸钙的关键 相似文献
235.
Kenji Arata Nobutaka Takeuchi Masaru Yoshinaka Ken Hirota Osamu Yamaguchi 《Journal of the American Ceramic Society》1997,80(8):2168-2170
Continuously graded MoSi2 -ZrO2 (2Y) materials with high density (97.5% of theoretical) have been fabricated by uniaxial wet-molding, followed by hot pressing (1000°C/1 h/30 MPa) and hot isostatic pressing (1400°C/2 h/196 MPa). Their composition profiles are greatly influenced by the viscosity of mixed solutions of glycerin and ethanol used as a dispersion medium; a linear compositional gradient from MoSi2 /ZrO2 (2Y) 70/30 to 20/80 mol% is obtained from the solution (50/50 vol%) with a viscosity of 20 mPa s. Vickers hardness (Hv) and fracture toughness (KIC) increase from 9.7 to 12.4 GPa and from 5.1 to 12.5 MPa m1/2, respectively, with increasing ZrO2 (2Y) composition. 相似文献
236.
Wataru Sugiyama Tomoo Yamamura Ki Chul Park Hiroshi Tomiyasu Yoshinobu Shiokawa Hidetsugu Okada Yuji Sugita 《Progress in Nuclear Energy》2005,47(1-4):448-453
Disposition of low-level radioactive wastes has been performed in supercritical water with RuO2 as a catalyst without the addition of any oxidizing materials. These wastes arose from nuclear power plants etc., constituting of nonflammable organic materials, such as fire resistant sheeting and rubber gloves. We investigated the distribution behavior of iron and cobalt attached to nonflammable organic materials, in solid, liquid and gas phases during the decomposition of this method. The distributions of these elements under various conditions (initial amounts) were determined by using their radioisotopes as simulated low-level radioactive wastes in order to ease the detection of trace amounts of elements even in solid and gas phases. Iron and cobalt were found only in the solid phase when non-radioactive iron hydroxide was added as a precipitation reagent before the supercritical-water reaction. 相似文献
237.
A GaAs/AlGaAs directional coupler switch, for the first time with a device length shorter than 1 mm, has been fabricated by utilising the good controllability of molecular beam epitaxy and reactive ion beam etching. The switching voltage is as low as 5V. The extinction ratio is 17dB for a crossover state and 14dB for a straight-through state. 相似文献
238.
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240.
H Tachikawa W Funahashi Y Takeuchi H Nakanishi R Nishihara S Katoh XD Gao T Mizunaga D Fujimoto 《Canadian Metallurgical Quarterly》1997,239(3):710-714
The third multicopy suppressor gene of the PDI1 deletion from Saccharomyces cerevisiae, MPD2, was isolated and characterized. The MPD2 gene encodes a protein with a putative signal sequence, ER retention signal, and a disulfide isomerase active site like sequence. The amino acid sequence around the active site like sequence is similar to the thioredoxin-like domains of PDI and PDI related proteins, although the similarity is comparatively low. A delta-pdi1 strain over-producing Mpd2p showed slow growth and was sensitive to 1 mM dithiothreitol. Mpd2p can be detected in wild type cells and is a glycoprotein. Although the MPD2 gene was not essential for growth, overexpression of the gene partially restored the maturation defect of carboxypeptidase Y caused by the PDI1 deletion. Mutagenesis analysis revealed that Mpd2p can compensate for the loss of PDI with its CXXC sequence. 相似文献