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991.
本文对宽带综合通信网交换系统几个主要方面技术的发展趋向作了概括介绍,内容包括:电子交换的分布结构、ATM交换的开始应用,个人通信的无线进网,宽带交换引用光子技术和多媒体交换结构分析。 相似文献
992.
GH Fan J Zhao YL Wu LG Lou Z Zhang Q Jing L Ma G Pei 《Canadian Metallurgical Quarterly》1998,53(4):684-690
The effects of N-methyl-D-aspartate (NMDA) on opioid receptor-mediated G protein activation were explored in neuroblastoma X glioma hybrid (NG108-15) cells. Treatment of the cells with NMDA resulted in a remarkable attenuation of [35S]guanosine-5'-O-(3-thio)triphosphate binding stimulated by [D-Pen2,D-Pen5]-enkephalin (DPDPE), a delta-opioid receptor agonist. The effects of NMDA were dose and time dependent with an IC50 value of 5 nM and could be blocked by NMDA receptor antagonists. After NMDA treatment, the DPDPE dose-response curve shifted to the right (EC50 value increased approximately 7-fold, from 6 to 40 nM), and the maximal response induced by DPDPE was reduced by approximately 60%. The effects of NMDA were reversible, and the DPDPE response could recover within 60 min. The functional responses of delta-, mu-, and kappa-opioid receptors in primarily cultured neurons also were attenuated significantly by NMDA treatment. The inhibitory effects of NMDA on opioid receptor-mediated G protein activation could be blocked by coadministration of the protein kinase C (PKC) inhibitors or by elimination of the extracellular Ca2+. Correspondingly, NMDA treatment of NG108 cells significantly elevated cellular PKC activity and stimulated Gialpha2 phosphorylation. Transient transfection into NG108-15 cells of the wild-type Gialpha2 and a mutated Gialpha2 (Ser144Ala) resulted in a 2-fold increase in DPDPE-stimulated G protein activation. The DPDPE responses were greatly inhibited by NMDA treatment in the wild-type Gialpha2-transfected cells but much less affected in the mutant Gialpha2-transfected cells. In summary, NMDA attenuates opioid receptor/G protein coupling, and this process requires activation of PKC. 相似文献
993.
994.
Y Zhang HP Hetherington EM Stokely GF Mason DB Twieg 《Canadian Metallurgical Quarterly》1998,39(6):999-1004
OBJECTIVE: To report our experience with erosion of permanent suture or mesh material after abdominal sacrocolpopexy. METHODS: A retrospective chart review was performed to identify patients who underwent sacrocolpopexy by the same surgeon over 8 years. Demographic data, operative notes, hospital records, and office charts were reviewed after sacrocolpopexy. Patients with erosion of either suture or mesh were treated initially with conservative therapy followed by surgical intervention as required. RESULTS: Fifty-seven patients underwent sacrocolpopexy using synthetic mesh during the study period. The mean (range) postoperative follow-up was 19.9 (1.3-50) months. Seven patients (12%) had erosions after abdominal sacrocolpopexy with two suture erosions and five mesh erosions. Patients with suture erosion were asymptomatic compared with patients with mesh erosion, who presented with vaginal bleeding or discharge. The mean (+/-standard deviation) time to erosion was 14.0+/-7.7 (range 4-24) months. Both patients with suture erosion were treated conservatively with estrogen cream. All five patients with mesh erosion required transvaginal removal of the mesh. CONCLUSION: Mesh erosion can follow abdominal sacrocolpopexy over a long time, and usually presents as vaginal bleeding or discharge. Although patients with suture erosion can be managed successfully with conservative treatment, patients with mesh erosion require surgical intervention. Transvaginal removal of the mesh with vaginal advancement appears to be an effective treatment in patients failing conservative management. 相似文献
995.
996.
讨论了底排弹射程标准化方法所满足的要求,分析了现行底排弹射程标准化方法存在的问题,对底排减阻模型进行了改进,并对试验数据进行了分析处理。 相似文献
997.
首先对仪器仪表电路中常用电阻器和电位器的技术性能作了较详细的介绍,然后结合电路设计实际提出了选用要点和测试方法. 相似文献
998.
叙述了体吸收激光能量计的特点,介绍了其标定方法,给出了其技术参数。体吸收激光地的推广应用取得了广泛的社会效益。 相似文献
999.
1000.
焊前处理方式对LF6铝合金扩散焊的影响 总被引:4,自引:0,他引:4
利用Gleeble-1500热/力模拟试验机,研究了LF6铝合金的扩散焊工艺,通过对焊接温度、压力、时间的调整和选用不同的料前处理方法,确定了最佳的扩散规范,研究结果表明:在一定的温度和时间范围内,LF65铝合金扩散焊接头的剪切哟度随焊接温度和时间的增加而提高;化学浸蚀法比机械打磨法能更有效的去除铝合金表面的氧化膜;在现有试验条件下,得到LF6铝合金扩散焊的最佳规范参数,搭接试扩散焊接头的剪切强度 相似文献