全球股市和石油类股2000年表现与2001年预测

回顾分析了2000年全球股市和石油类股表现,指出了石油类股表现稳健增长的原因;对2001年全球股市和石油类股表现作出预测;最后分析了中石油、中石化上市的表现。     

WTO《与贸易有关的投资措施协议》解读

投资措施是乌拉圭回合谈判的新议题之一,因涉及国家主权问题,遭到发展中国家极力反对,经过让步和妥协,《与贸易有关的投资措施协议》（以下简称协议）仅限于货物贸易,不涉及服务贸易。     

吸收塔填料层高度的解析计算

对相平衡线为曲线的低浓度吸收操作系统,提出分段计算和曲线拟合—数值积分两种解析算法。这两种方法可得到满意的计算精度,同时可用计算机进行计算,方便易行     

石墨层间化合物在插层过程中阶的转变模式

应用原位ＸＲＤ（Ｘ射线衍射）法,研究了石墨层间化合物（ＣＩＣ）在插层过程中阶次的转变模式。结果表明：不同的插层体系和插层条件产生不同的成核和扩散情况,从而导致在插层过程中试样的不同阶次转变模式。     

基于波形比较的架空配电线路故障离线定位自动计算方法

现有的架空配电线路在线故障定位方法存在只能确定故障区段的不足,离线故障定位方法则存在故障定位灵敏度低与精度差的问题.针对上述问题,建立高压脉冲冲击线路响应模型,通过分析故障线路电流分布特征与波形差异,提出了一种基于波形比较的架空配电线路故障离线定位自动计算方法.该方法使用高压脉冲信号发生器向故障线路注入直流脉冲信号,以...     

陶瓷材料磨削表面残余应力的产生机理

在磨削加工过程中产生表面残余应力,其产生机理是磨粒刃作用引起的挤压应力和切削应力及热应力的综合作用效应。挤压应力产生残余压应力;切削引起的残余应力存在拉、压应力两种可能,但比挤压应力要小得多;热应力产生残余拉应力。     

Haemoglobin response modelling under erythropoietin treatment: Physiological model-informed machine learning method

Patients with renal anaemia are usually treated with recombinant human erythropoietin (EPO) because of insufficient renal EPO secretion. The establishment of a good haemoglobin (Hgb) response model is a necessary condition for dose optimization design. The purpose of this paper is to apply physics-informed neural networks (PINN) to build the Hgb response model under EPO treatment. Neural network training is guided by a physiological model to avoid overfitting problems. During the training process, the parameters of the physiological model can be estimated simultaneously. To handle differential equations with impulse inputs and time delays, we propose approximate model equations for the pharmacokinetic (PK) model and the pharmacodynamic (PD) model, respectively. The modified PK/PD model was incorporated into PINN for training. Tests on simulated data and clinical data show that the proposed method has better performance than data-driven modelling methods and the traditional physiological modelling based on the least squares method.     

改性柑橘果胶-乳清蛋白稳定的精油Pickering乳液

以改性柑橘果胶和乳清蛋白为乳化剂，对月桂精油、百里香精油、牛至精油及佛手柑精油进行包埋，通过高压均质法制备了改性柑橘果胶-乳清蛋白复合纳米粒稳定的四种精油Pickering乳液。采用马尔文激光粒度仪、SEM、FTIR和哈克流变仪等对乳液进行了表征，并通过药敏实验评价了乳液的抑菌效果。结果表明，经过辐照处理后的改性果胶的乳化能力显著增强，提高至548.11 m2/g。红外光谱证明了聚合物的形成和精油的成功包封。乳液粒径大小在829~1147 nm之间，耐受离心且贮存77d后的稳定性均高于90%。流变学测试表明，四种乳液均属于假塑性流体。乳液对不同精油的包封率为5.81%~21.54%，负载率为0.81%~5.81%，且对包埋的精油具有控释效果。四种乳液对两种食品微生物（大肠杆菌和金黄色葡萄球菌）均具有显著抑制作用，抑菌圈范围为7.51~34.98 mm。     

临海市海绵城市建设实施方案编制实践与思考

针对目前海绵城市建设实施方案主要从市政角度考虑、强调低影响开发措施应用、缺乏海绵城市系统建设理念的现实,以临海市为例,从流域治水角度,从问题与需求出发,统筹外围保障工程与内部实施方案两大工程体系,总结海绵城市实施方案编制实践要点,对未来我国海绵城市建设的推广提出建议。     

Dynamical Integration of Antimicrobial,Anti-Inflammatory,and Pro-Osteogenic Activities on Polyetheretherketone via a Porous N-Halamine Polymeric Coating

Polyetheretherketone (PEEK) has been widely used as orthopedic implants, but the poor antimicrobial and osseointegration properties hinder its advanced clinical applications. Most of the modification strategies are difficult to temporally fulfill initial broad-spectrum antimicrobial and later pro-osteogenic requirements for a long-term success of implantation. N-halamine is a kind of biofriendly antimicrobial agent, and its functional N─Cl groups could be converted into N─H groups, potentially resulting in new bioactivities. Therefore, it is supposed that N-halamine might provide a feasible design for the dynamical integration of antimicrobial and pro-osteogenic abilities. Herein, a new class of surface-porous PEEK implant with an N-halamine polymeric coating (sp-PEEK-NCl) is constructed by successive pore-making, polymer grafting, and chlorination. The as-prepared sp-PEEK-NCl exhibits broad-spectrum antibacterial, antifungal, anti-inflammatory, and pro-osteogenic effects. More importantly, with the consumption of oxidative chlorine, the N─Cl groups in sp-PEEK-NCl are transformed into N─H groups with enhanced pro-osteogenic ability, endowing sp-PEEK-NCl with dynamically compatible bioactivities for osseointegration in different periods after implantation. Rat implant-associated osteomyelitis model confirms that sp-PEEK-NCl obviously reduces infectious bone destruction and promotes osseointegration in vivo. This work may provide a promising strategy for intelligent integration of bioactivities and valuable insight into the design of orthopedic implants in bone tissue engineering.