Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats

In the present study, post inflammation irritable bowel syndrome (PI-IBS) rats were firstly established by intracolonic instillation of acetic acid with restraint stress. Then the pharmacokinetics of berberine in the rat plasma were compared after oral administration of berberine hydrochloride (25 mg/kg) to normal rats and PI-IBS rats. Quantification of berberine in the rat plasma was achieved by using a sensitive and rapid UPLC-MS/MS method. Plasma samples were collected at 15 different points in time and the pharmacokinetic parameters were analyzed by WinNonlin software. Compared with the normal group, area under the plasma concentration vs. time curve from zero to last sampling time (AUC_0–t) and total body clearance (CL/F) in the model group significantly increased or decreased, (2039.49 ± 492.24 vs. 2763.43 ± 203.14; 4999.34 ± 1198.79 vs. 3270.57 ± 58.32) respectively. The results indicated that the pharmacokinetic process of berberine could be altered in PI-IBS pathological conditions.     

Quench Sensitivity of AA7N01 Alloy Used for High-Speed Train Body Structure

JOM - The quench sensitivity of AA7N01 aluminum alloy used for high-speed train body structure was investigated by end-quenching test, time–temperature-transformation curves simulation,...     

高层建筑施工中大体积混凝土的裂缝控制

高层混凝土建筑的裂缝控制应该防患于未然,尽量预防有害裂缝,科学地将其有害程度控制在规范允许的范围内。只要使设计与施工能紧密结合,将裂缝控制在无害范围内是完全可以做到的。本文探讨了高层建筑施工中大体积混凝土的裂缝控制措施。     

便携式斯特林深冷冰箱研制

研制了一种以斯特林低温制冷机为冷源,有效容积6L,工作温度范围-60℃～-160℃的深冷冰箱.小型斯特林制冷机采用直线电机驱动,电机与压缩机一体化设计,采用氦气制冷工质.斯特林制冷机的冷指置于冰箱内底端直接冷却.圆柱形箱体采用了内环为真空层、外环为硬质聚氨酯发泡层的复合绝热技术,设计了具有3层辐射屏的内盖和真空箱盖.该冰箱具有环境友好、热效率高、制冷温区宽、制冷量易控和体积小等特点,可以满足低温保存和实验等需求.输入功率170W时冰箱内温度低于-150℃,对应-100℃低温时的制冷量为7W.     

HIPS/PPO共混物拉伸和冲击断裂面的电镜观察

研究了高冲击强度聚苯乙烯(HIPS)/聚苯醚(PPO)共混物断面3个特征区的形貌特征及形成机制,分析了它们对材料力学性能的影响。     

核电厂主螺栓超声检测与信号分析

依据RSE-M标准需要定期对核电厂反应堆压力容器(RPV)主螺栓进行超声检测,为了保证主螺栓螺纹区及光杆区不同深度刻槽的超声检测灵敏度,本文对检测工艺进行声场仿真计算,分析与判断数据采集中的相关信号与非相关信号,并重点分析裂纹信号的特征,验证了超声工艺的可靠性。结合现场实施案例,通过45°横波端角反射率高的特性,综合其他检测方法如涡流和渗透检测对缺陷性质进行判定,可有效确定异常信号。     

基于模糊PID控制的循环水自动加药与监测系统

工业生产中加强对循环水质的处理变得越来越重要,在对循环水系统存在问题进行分析后,利用西门子S7-200 PLC和WinCC组态软件开发设计了新型工业循环水水质在线监测与自动加药系统,解决了传统控制难以保证加药量准确与均匀的问题;针对加酸中pH值过程具有非线性、时变和大时滞等特点,采用了以控制人员的经验为基础的模糊控制方法,结果表明pH值控制误差完全满足系统要求;系统已在化工厂中投入运行,经实践证明,该系统人机交互性好、可靠性高、抗干扰能力强,满足了现代工业循环水质监管的要求。     

BIM技术在天津永基花园二期项目中的应用

文章介绍了天津市永基花园二期项目BIM的应用背景、建模过程、碰撞检查、三维场布、BIM5D软件应用等,分析了BIM在该项目中的应用价值、存在问题,并提出了对BIM应用的展望。     

基于短波测量数据的信道模型聚类方法

提出了一种使用减法聚类有效分类离散随机信道参数的方法．在青岛北京链路的信道测量数据基础上,使用该方法将短波信道测量计算出的信道参数分别进行一维和多维聚合分类,得到在特定链路、时间上,某频率对应的典型信道参数和信道模型,为短波频谱管理中的频率打分提供精确量化依据．     

Genetic Dissection of Phosphorus Use Efficiency and Genotype-by-Environment Interaction in Maize

Genotype-by-environment interaction (G-by-E) is a common but potentially problematic phenomenon in plant breeding. In this study, we investigated the genotypic performance and two measures of plasticity on a phenotypic and genetic level by assessing 234 maize doubled haploid lines from six populations for 15 traits in seven macro-environments with a focus on varying soil phosphorus levels. It was found intergenic regions contributed the most to the variation of phenotypic linear plasticity. For 15 traits, 124 and 31 quantitative trait loci (QTL) were identified for genotypic performance and phenotypic plasticity, respectively. Further, some genes associated with phosphorus use efficiency, such as Zm00001eb117170, Zm00001eb258520, and Zm00001eb265410, encode small ubiquitin-like modifier E3 ligase were identified. By significantly testing the main effect and G-by-E effect, 38 main QTL and 17 interaction QTL were identified, respectively, in which MQTL38 contained the gene Zm00001eb374120, and its effect was related to phosphorus concentration in the soil, the lower the concentration, the greater the effect. Differences in the size and sign of the QTL effect in multiple environments could account for G-by-E. At last, the superiority of G-by-E in genomic selection was observed. In summary, our findings will provide theoretical guidance for breeding P-efficient and broadly adaptable varieties.