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Nanoparticulate Delivery of Cancer Cell Membrane Elicits Multiantigenic Antitumor Immunity 下载免费PDF全文
Ashley V. Kroll Ronnie H. Fang Yao Jiang Jiarong Zhou Xiaoli Wei Chun Lai Yu Jie Gao Brian T. Luk Diana Dehaini Weiwei Gao Liangfang Zhang 《Advanced materials (Deerfield Beach, Fla.)》2017,29(47)
Anticancer vaccines train the body's own immune system to recognize and eliminate malignant cells based on differential antigen expression. While conceptually attractive, clinical efficacy is lacking given several key challenges stemming from the similarities between cancerous and healthy tissue. Ideally, an effective vaccine formulation would deliver multiple tumor antigens in a fashion that potently stimulates endogenous immune responses against those antigens. Here, it is reported on the fabrication of a biomimetic, nanoparticulate anticancer vaccine that is capable of delivering autologously derived tumor antigen material together with a highly immunostimulatory adjuvant. The two major components, tumor antigens and adjuvant, are presented concurrently in a fashion that maximizes their ability to promote effective antigen presentation and activation of downstream immune processes. Ultimately, it is demonstrated that the formulation can elicit potent antitumor immune responses in vivo. When combined with additional immunotherapies such as checkpoint blockades, the nanovaccine demonstrates substantial therapeutic effect. Overall, the work represents the rational application of nanotechnology for immunoengineering and can provide a blueprint for the future development of personalized, autologous anticancer vaccines with broad applicability. 相似文献
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Cao Jinfeng Lai Jianzhong Zhou Jiehang Kang Ningyu Du Longyu Miao Yiqiu 《Journal of Mechanical Science and Technology》2020,34(7):2783-2793
Journal of Mechanical Science and Technology - A lightweight multilayer ceramic composite armor with a sandwich structure back plate was proposed by studying the penetration process, damage... 相似文献
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Jiadong Yu Lai Wang Zhibiao Hao Yi Luo Changzheng Sun Jian Wang Yanjun Han Bing Xiong Hongtao Li 《Advanced materials (Deerfield Beach, Fla.)》2020,32(15):1903407
III-nitride semiconductors have attracted considerable attention in recent years owing to their excellent physical properties and wide applications in solid-state lighting, flat-panel displays, and solar energy and power electronics. Generally, GaN-based devices are heteroepitaxially grown on c-plane sapphire, Si (111), or 6H-SiC substrates. However, it is very difficult to release the GaN-based films from such single-crystalline substrates and transfer them onto other foreign substrates. Consequently, it is difficult to meet the ever-increasing demand for wearable and foldable applications. On the other hand, sp2-bonded two-dimensional (2D) materials, which exhibit hexagonal in-plane lattice arrangements and weakly bonded layers, can be transferred onto flexible substrates with ease. Hence, flexible III-nitride devices can be implemented through such 2D release layers. In this progress report, the recent advances in the different strategies for the growth of III-nitrides based on 2D materials are reviewed, with a focus on van der Waals epitaxy and transfer printing. Various attempts are presented and discussed herein, including the different kinds of 2D materials (graphene, hexagonal boron nitride, and transition metal dichalcogenides) used as release layers. Finally, current challenges and future perspectives regarding the development of flexible III-nitride devices are discussed. 相似文献
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The white-box attack is a new attack context in which it is assumed that cryptographic software is implemented on an un-trusted platform and all the implementation details are controlled by the attackers. So far, almost all white-box solutions have been broken. In this study, we propose a white-box encryption scheme that is not a variant of obfuscating existing ciphers but a completely new solution. The new scheme is based on the unbalanced Feistel network as well as the ASASASA (where “A” means affine, and “S” means substitution) structure. It has an optional input block size and is suitable for saving space compared with other solutions because the space requirement grows slowly (linearly) with the growth of block size. Moreover, our scheme not only has huge white-box diversity and white-box ambiguity but also has a particular construction to bypass public white-box cryptanalysis techniques, including attacks aimed at white-box variants of existing ciphers and attacks specific to the ASASASA structure. More precisely, we present a definition of white-box security with regard to equivalent key, and prove that our scheme satisfies such security requirement. 相似文献
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为了解决光伏阵列电站中的光伏组件由于各种原因产生失效,不能及时发现、维护而导致较大的经济损失问题,提出了一种通过在PV组件接线盒上安装无线温度传感器,动态的监控旁路二极管温度间接监测失效组件的新方法,该方法能够在不影响光伏组件结构的情况下及时发现、定位光伏阵列中失效的光伏组件;文中对热斑效应形成和温度测量法的联系以及异常数据点的处理做了较为详细的阐述,设计了温度采集和无线传输系统的硬件电路,电路简单、可靠,成本低廉易于实现,采集精度符合设计要求;并编写了PC端的的监测系统的程序,通过对PV组件失效进行遮挡验证,结果表明基于温度测量法的光伏阵列失效组件监测系统检测结果可靠温度,易于使用。 相似文献
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