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From the perspective of its inherent promises, difficulties, elusiveness, and relative discontinuity, the pursuit of integration in planning could be compared to the Quest for the Holy Grail. The aim of this paper is to identify the main commitments and impediments to pursued integration in the former Yugoslavia’s planning from the late 1950s until the late 1980s, drawing on the theoretical discourse, legislative, and institutional framework and the case study of the spatial plan preparation in the Socialist Republic of Serbia. During the chosen period, different aspects of integrated approach to spatial and urban planning were pursued in a context of creating and failing to deliver a unique Yugoslav version of the welfare state – the self-management socialism. In this light, the intended integration is contrasted to poor outcomes, which led to the loss of legitimacy and the final dissolution of the state, its ideology, governance, and socio-economic planning. The conclusion reflects on the main merits and pitfalls of the former Yugoslavia’s experiment to illuminate some general risks associated with the integrated approach in planning.  相似文献   
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The impact of ultrasound waves generated by probe‐type sonicator and ultrasound cleaning bath on egg white protein susceptibility to hydrolysis by alcalase compared to both thermal pretreatment and conventional enzymatic hydrolysis was quantitatively investigated. A series of hydrolytic reactions was carried out in a stirred tank reactor at different substrate concentrations, enzyme concentrations, and temperatures using untreated, and pretreated egg white proteins (EWPs). The kinetic model based on substrate inhibition and second‐order enzyme deactivation successfully predicts the experimental behavior providing an effective tool for comparison and optimization. The ultrasound pretreatments appear to greatly improve the enzymatic hydrolysis of EWPs under different conditions when compare to other methods. The apparent reaction rate constants for proteolysis (k2) are 0.009, 0.011, 0.053, and 0.045 min?1 for untreated EWPs, and those pretreated with heat, probe‐type sonicator, and ultrasound cleaning bath technologies, respectively. The ultrasound pretreatment also decreases hydrolysis activation (Ea) and enzyme deactivation (Ed) energy, enthalpy (ΔH), and entropy (ΔS) of activation and for the probe‐type sonication this decrease is 61.7%, 61.6%, 63.6%, and 32.2%, respectively, but ultrasound has little change in Gibbs free energy value in the temperature range of 318 to 338 K. The content of sulfhydryl groups and ζ potential show a significant increase (P < 0.05) for both applied ultrasound pretreatments and the reduction of particle size distribution are achieved, providing some evidence that the ultrasound causes EWP structural changes affecting the proteolysis rate.  相似文献   
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The urban planning profession and its activities in Eastern and Central Europe have been affected by the political and economic transformation in these countries. The new, still evolving societal and institutional frameworks present urban planners with a highly dynamic context to which they must adapt. In contrast to relatively predictable centrally planned and controlled development, the cities there are now subjected to multiple forces and immense pressures on their already fragile environments. This article reviews the frameworks, trends, and issues that characterize the planning practice in this transitional period as evidenced in the capital cities of Prague, Bratislava, and Budapest. Planners in the U.S. and Western Europe will find many of these topics relevant to past, present, and future circumstances they face. The article provides for mutual learning and exchange of experiences, and for better understanding and improvement of planning systems and practice. It relates to the core dilemma in justifying planning as government intervention vis-a-vis free market rule.  相似文献   
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The internal oxidation (IO) of Ag–VC composites containing 5 vol.% of carbide was examined at three oxidation temperatures (350, 400, 600 °C). Two mechanisms were observed due to the formation of double oxides with relatively low-melting points. At temperatures below the lowest eutectic point in situ, or diffusion less IO, was observed with the formation and growth of oxide layers surrounding the initial carbide. At temperatures above the eutectic point IO resulted in the formation of liquid oxide pools, which grew in size and developed into a network of oxides within the metal matrix. The kinetics confirmed the presence of two distinct mechanisms.  相似文献   
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Novel ferromagnetic semiconducting polyaniline PANI/TiO2 nanocomposites were synthesized by the oxidative polymerization of aniline with ammonium peroxydisulfate in an aqueous medium, in the presence of colloidal TiO2 nanoparticles (d ∼ 4.5 nm), without added acid. The morphological, magnetic, structural, and optical properties of the PANI/TiO2 nanocomposites prepared at initial aniline/TiO2 mole ratios 80, 40, and 20 were studied by scanning electron microscopy, superconducting quantum interference device, X‐ray powder diffraction, FTIR, Raman, and UV‐Vis spectroscopies. The emeraldine salt form of linear PANI chains as well as the presence of phenazine units, branched PANI chains, and anatase crystalline structure of TiO2 in PANI/TiO2 nanocomposites was confirmed by FTIR and Raman spectroscopies. The electrical conductivity of synthesized composites was ∼10−3 S cm−1. The room temperature ferromagnetic response with coercive field of Hc ∼ 300 Oe and the remanent magnetization of Mr ∼ 4.35 × 10−4 emu/g was detected in all investigated PANI/TiO2 nanocomposites. POLYM. COMPOS., 2012. © 2012 Society of Plastics Engineers  相似文献   
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Article describes the synthesis of fifteen β-hydroxy-β-arylalkanoic acids by Reformatsky reaction using the 1-ethoxyethyl-2-bromoalkanoates, aromatic or cycloalkyl ketones or aromatic aldehydes. The short survey of previously reported synthetic procedures for title compounds, is given. The majority of obtained compounds exert antiproliferative activity in vitro toward human: HeLa, Fem-X cells, K562, and LS174 cells, having IC50 values from 62.20 to 205 μM. The most active compound is 3-OH-2,2-di-Me-3-(4- biphenylyl)-butanoic acid, having the IC50 value 62.20 μM toward HeLa cells. Seven examined compounds did not affect proliferation of healthy human blood peripheral mononuclear cells (PBMC and PBMC+ PHA), IC50 > 300 μM. The preliminary QSAR results show that estimated lipophilicity of compounds influences their antiproliferative activity in the first place. The ability of dehydration, and the spatial arrangement of hydrophobic portion, HBD and HBA in molecules are has almost equal importance as lipophilicity.  相似文献   
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