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31.
A 50 year old man presented with sudden abdominal pain, abdominal distension and shock. At emergency laparotomy a large amount of blood was found in the peritoneal cavity. There was micronodular cirrhosis of the liver and the spleen was enlarged. The bleeding was traced to distended veins in the right paracolic gutter which were oversewn and the abdomen closed. A coagulopathy was diagnosed and treatment including high dose aprotinin commenced. However, he continued to bleed and at a second laparotomy the area of previous haemorrhage was packed. Further deterioration continued until death 12 hours later. Intraperitoneal haemorrhage from ectopic varices is a rare occurrence. There is a high mortality rate usually due to an advanced coagulopathy. This is the first report of aprotinin being used in an attempt to treat this. On the basis of this report aprotinin would not seem to be of benefit for this condition. 相似文献
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33.
The authors previously reported that American shad (Alosa sapidissima) can detect sounds from 100 Hz to 180 kHz, with two regions of best sensitivity, one from 200 to 800 Hz and the other from 25 to 150 kHz [Mann et al., Nature 389, 341 (1997)]. These results demonstrated ultrasonic hearing by shad, but thresholds at lower frequencies were potentially masked by background noise in the experimental room. In this study, the thresholds of the American shad in a quieter and smaller tank, as well as thresholds for detecting stimulated echolocation sounds of bottlenosed dolphins was determined. Shad had lower thresholds for detection (from 0.2 to 0.8 kHz) in the quieter and smaller tank compared with the previous experiment, with low-frequency background noise but similar thresholds at ultrasonic frequencies. Shad were also able to detect echolocation clicks with a threshold of 171 dB re: 1 microPa peak to peak. If spherical spreading and an absorption coefficient of 0.02 dB/m of dolphin echolocation clicks are assumed, shad should be able to detect echolocating Tursiops truncatus at ranges up to 187 m. The authors propose that ultrasonic hearing evolved in shad in response to selection pressures from echolocating odontocete cetaceans. 相似文献
34.
BACKGROUND AND OBJECTIVES: Women who are undergoing tubal sterilization are at risk for various sexually transmitted diseases (STDs) if they do not use a barrier method of contraception. There is a paucity of data concerning dual use of condoms among sterilized women. GOAL: Planned use of condoms for protection against STDs was examined among 2,782 women undergoing surgical sterilization from 1991 to 1996. STUDY DESIGN: Cross-sectional survey. RESULTS: Planned condom use increased significantly over the 6-year study period. Of women who were using condoms before sterilization (n = 646), nearly half indicated no plans to do so after becoming sterilized. Thus, 11% of the total sample experienced an increased risk for exposure to human immunodeficiency virus or other STDs. Condom abandonment was significantly higher among Hispanic and married women. Multiple regression analysis was used to examine the association between condom use and various characteristics. Factors associated with future condom use were younger age, black ethnicity, being unmarried, previous STD, not having a steady partner, higher number of previous sexual partners, having used condoms for disease prevention in the past, and lack of partner involvement in the decision to undergo sterilization. CONCLUSIONS: Use of condoms among sterilized women appears to be on the rise, women at higher risk for disease are more likely than others to be using condoms, and only a small group of women experience an increased risk for exposure to disease as a result of selecting this permanent method of contraception. 相似文献
35.
CT Lai VA Tanay GA Rauw AN Bateson IL Martin GB Baker 《Canadian Metallurgical Quarterly》1997,704(1-2):175-179
Reported here is a rapid, sensitive and relatively inexpensive procedure using gas chromatography with nitrogen-phosphorus detection (GC-NPD) to quantify buspirone levels in brains of rats. The analyte was directly extracted from brain homogenate with toluene after basification and then subjected to GC-NPD analysis using a capillary column. The calibration curves were linear over the range of 10 to 320 ng per 2 ml of brain homogenate, with typical r2 values >0.99. The assay was highly reproducible and gave peaks with excellent chromatographic properties. 相似文献
36.
M Cuchacovich NN Tchernitchin H Gatica R Wurgaft L Contreras AN Tchernitchin 《Canadian Metallurgical Quarterly》1996,124(2):160-169
BACKGROUND: The target cellular response to glucocorticoids is proportional to the concentrations or affinity of specific receptors to these substances. AIM: To look for a correlation between glucocorticoid receptor concentrations in synovial wall cells and the clinical response to steroidal treatment in patients with rheumatoid arthritis. PATIENTS AND METHODS: Twenty eight patients with rheumatoid arthritis were studied. Each subject was subjected to a synovial biopsy, in which a dry radioautographic technique for diffusible compounds was used. Patients were treated afterwards with three 500 mg intravenous pulses of methilprednisolone. RESULTS: A mean of 44.8% of synovial cells (range 30.1-62.8%) had binding sites for 3H dexamethasone. All patients had a significant clinical improvement after methylprednisolone. Multiple regression analysis did not show a correlation between clinical response and glucocorticoid receptor concentration. CONCLUSIONS: The lack of association between glucocorticoid receptor concentrations and clinical response could be due to the large steroid dose used, that saturated all available receptors. 相似文献
37.
Gluconobacter oxydans possesses a unique organization of metabolic systems, which are characterized by reduction of major dissimilation pathways, surface localization of main oxidative enzymes responsible for partial oxidation of carbon substrates, high performance of electron-transport chains, and accumulation of partially oxidized metabolites in the medium. These features allow us to use the cells of these microorganisms in biotechnology for production of several food products and medicines. The use of G. oxydans in biosensors for estimation of concentrations of sugars, aldoses and polyalcohols is promising. Physiological and biochemical features of these microorganisms enabling their use in biotechnology and receptor elements of biosensors are reviewed. 相似文献
39.
针对具有方位谱混叠现象的斜视聚束式合成孔径雷达(SAR)成像问题,本文研究了一种基于去调频技术的成像方法.文中首先分析了斜视聚束SAR中的方位谱混叠现象,从理论上找出了斜视角影响方位粗聚焦的根本原因.基于分析结果,引入了回波信号非线性相位校正预处理法,彻底消除了斜视角的影响,从而得到正确的粗聚焦结果.然后基于斜视成像模型,推导了预处理回波信号的方位粗聚焦和精聚焦处理过程.在精聚焦的方位滤波处理中,针对非线性相位校正预处理导致的场景聚焦深度限制问题,提出了一种改进的非线性调频变标(NLCS)算法,实现了回波信号的高精度方位压缩.仿真实验结果证明了文中理论分析的正确性和所提方法的有效性. 相似文献
40.
目前反倾岩质边坡弯曲倾倒破坏分析方法仍以基于极限平衡理论的悬臂梁模型为主,但大多未考虑坡脚岩层的剪切破坏。为准确评价该类边坡的稳定性,建立考虑坡脚岩层剪切破坏的分析计算方法。首先,根据岩层变形破坏特征,将边坡分为后缘稳定区、中部弯曲倾倒区和前缘剪切区3个区域;其次,建立弯曲倾倒-剪切滑移破坏模式的稳定性分析方法;最后,通过工程实例验证,并进行参数分析。研究结果表明:提出的分析方法与工程实际符合性较好;边坡在倾角较陡、坡角较大时稳定性最差,坡角对边坡稳定性影响大于岩层倾角的影响;岩层厚度及层面内摩擦角增加有利于边坡稳定性,且会扩大坡脚剪切区范围。研究成果对反倾岩质边坡破坏的防治具有实践指导意义。 相似文献