Bioinspired yeast microcapsules loaded with self-assembled nanotherapies for targeted treatment of cardiovascular disease

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Hollow Pd/MOF Nanosphere with Double Shells as Multifunctional Catalyst for Hydrogenation Reaction

A new type of hollow nanostructure featured double metal‐organic frameworks shells with metal nanoparticles (MNPs) is designed and fabricated by the methods of ship in a bottle and bottle around the ship. The nanostructure material, hereinafter denoted as Void@HKUST‐1/Pd@ZIF‐8, is confirmed by the analyses of photograph, transmission electron microscopy, scanning electron microscopy, powder X‐ray diffraction, inductively coupled plasma, and N₂ sorption. It possesses various multifunctionally structural characteristics such as hollow cavity which can improve mass transfer, the adjacent of the inner HKUST‐1 shell to the void which enables the matrix of the shell to host and well disperse MNPs, and an outer ZIF‐8 shell which acts as protective layer against the leaching of MNPs and a sieve to guarantee molecular‐size selectivity. This makes the material eligible candidates for the heterogeneous catalyst. As a proof of concept, the liquid‐phase hydrogenation of olefins with different molecular sizes as a model reaction is employed. It demonstrates the efficient catalytic activity and size‐selectivity of Void@HKUST‐1/Pd@ZIF‐8.     

Application potential of bone marrow mesenchymal stem cell (BMSCs) based tissue-engineering for spinal cord defect repair in rat fetuses with spina bifida aperta

Spina bifida aperta are complex congenital malformations resulting from failure of fusion in the spinal neural tube during embryogenesis. Despite surgical repair of the defect, most patients who survive with spina bifida aperta have a multiple system handicap due to neuron deficiency of the defective spinal cord. Tissue engineering has emerged as a novel treatment for replacement of lost tissue. This study evaluated the prenatal surgical approach of transplanting a chitosan–gelatin scaffold seeded with bone marrow mesenchymal stem cells (BMSCs) in the healing the defective spinal cord of rat fetuses with retinoic acid induced spina bifida aperta. Scaffold characterisation revealed the porous structure, organic and amorphous content. This biomaterial promoted the adhesion, spreading and in vitro viability of the BMSCs. After transplantation of the scaffold combined with BMSCs, the defective region of spinal cord in rat fetuses with spina bifida aperta at E20 decreased obviously under stereomicroscopy, and the skin defect almost closed in many fetuses. The transplanted BMSCs in chitosan–gelatin scaffold survived, grew and expressed markers of neural stem cells and neurons in the defective spinal cord. In addition, the biomaterial presented high biocompatibility and slow biodegradation in vivo. In conclusion, prenatal transplantation of the scaffold combined with BMSCs could treat spinal cord defect in fetuses with spina bifida aperta by the regeneration of neurons and repairmen of defective region.     

高熵合金氮化物薄膜的研究进展

基于多元高熵合金思想制备的高熵合金氮化物薄膜由于多种元素相互混合,易于产生高熵效应、晶格畸变效应和缓慢扩散效应,使得该新型薄膜体系形成简单的非晶结构和纳米晶结构。依赖于成分和制备工艺,多元高熵合金氮化物薄膜表现出简单的固溶体结构和优异的性能,因而在许多领域极具应用潜力。综述了高熵合金氮化物薄膜的发展概况、组织特点、性能特征、制备方法和应用前景,并对高熵合金氮化物薄膜的发展方向进行了展望。     

Fabrication of Titanium Aluminides via Powder-Cored Wire Arc Additive Manufacturing: Microstructural and Mechanical Characterization

Herein, an innovative powder-cored wire arc additive manufacturing (PC-WAAM) process is proposed to fabricate γ-TiAl thin-walled intermetallic alloy. The metallography, phase composition, and mechanical properties at different thin-wall locations are characterized. The results show that the alternatively distributed layer-like microstructure composed of α₂ (Ti₃Al) and γ (TiAl) phases is obtained along the building direction. The content of α₂ phase exhibits the tendency of decreasing from the bottom to top region. This unique microstructure characteristic is closely related to the typical thermal cycling history during deposition. Moreover, the tensile strength and microhardness of the top region are lower than the middle and bottom region. In general, the current PC-WAAM technique shows promising capability of fabricating γ-TiAl intermetallic alloy with low cost. This work becomes a valuable reference for understanding the evolution mechanism of microstructure and paves the way for the flexible and customized additive manufacturing of γ-TiAl alloy.     

Morphological Models for the Collapse of Area Features in Digital Map Generalization

Collapse is an essential operation for the manipulation of area features in digital data generalization. This operation can be categorized into two types: complete collapse and partial collapse. The former is composed of another two types: area-to-point and area-to-line collapse. In this paper, a set of algebraic models built upon the operators in mathematical morphology is described for the area-to-line collapse and partial collapse operations. For the area-to-line collapse operation, a modified skeleton algorithm is presented. For the partial collapse operation, a procedure is designed which consists of a set of operations, i.e., the skeletonization, separation of areal and linear parts, simplification of areas and an overlay operation. These models are tested using real map data sets.     

Silicon-based microelectrode arrays for stimulation and signal recording of in vitro cultured neurons

Microelectrode arrays (MEAs) for stimulation and signal recording of in vitro cultured neurons are presented.Each MEA is composed of 60 independent electrodes with 59 working ones and one reference one.These electrodes are divided into 30 pairs.Through each pair of electrodes,four independent states can be realized to define the accessing modes of neurons cultured on the surface of the electrodes.A total MEA covers an area of 10 mm×10 mm.MEAs are fabricated in a silicon-based semiconductor process.An implemented MEA is bonded on a specially designed printed-circuit-board (PCB) and surrounded by a culture chamber.An impedance measurement has been made to verify the electrical characteristics of MEAs.The surface was modified to enhance the biocompatibility.A series of PC12 cells culture experiments validates the effectiveness of the modification.An extracellular signal recording experiment with acetylcholine (Ach) as a stimulant has been carried out,and the results show the feasibility of MEAs for extracellular action potential recording.Extracellular electrical stimulation and recording experiments have been carried out too.They indicate that MEAs can be used for extracellular stimulation,recording,simultaneous stimulation and recording,and isolation of PC12 cells network cultured in vitro.     

基于SIMD结构的多标准LDPC译码器的VLSI实现

近年来,支持多标准的LDPC译码器已逐渐成为研究的热点.与传统译码器相比,所设计的LDPC译码器具有以下优点:1.实现了一个码率、码长可配置结构,进而可以支持多种标准;2.采用了一种改进型TPMP算法,使译码器的存储器容量大大减少,避免了因分块LDPC码的非规则性所造成的数据冲突问题;3.采用基于SIMD处理器的硬件结构,实现了硬件的高度规整性,易于芯片布局布线;4.设计了一个6级可配置流水线,可分时构造校验节点处理单元和变量节点处理单元,提高了硬件利用率和系统数据吞吐率.用这种架构实现了一个同时支持CMMB和DTMB两个标准的多标准LDPC译码器;芯片规模为75万门,时钟频率为220MHz,数据吞吐率为300Mbps.