Creation and control of high-dimensional multi-partite classically entangled light

Vector beams, non-separable in spatial mode and polarisation, have emerged as enabling tools in many diverse applications, from communication to imaging. This a...     

The Regulatory Role of H19/miR-181a/ATG5 Signaling in Perinatal Nicotine Exposure-Induced Development of Neonatal Brain Hypoxic-Ischemic Sensitive Phenotype

Nicotine exposure either from maternal cigarette smoking or e-cigarette vaping is one of the most common risk factors for neurodevelopmental disease in offspring. Previous studies revealed that perinatal nicotine exposure programs a sensitive phenotype to neonatal hypoxic-ischemic encephalopathy (HIE) in postnatal life, yet the underlying mechanisms remain undetermined. The goal of the present study was to determine the regulatory role of H19/miR-181a/ATG5 signaling in perinatal nicotine exposure-induced development of neonatal brain hypoxic-ischemic sensitive phenotype. Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps. All experiments were conducted in offspring pups at postnatal day 9 (P9). Perinatal nicotine exposure significantly enhanced expression of miR-181a but attenuated autophagy-related protein 5 (ATG5) mRNA and protein levels in neonatal brains. Of interest, miR-181a mimicking administration in the absence of nicotine exposure also produced dose-dependent increased hypoxia/ischemia (H/I)-induced brain injury associated with a decreased ATG5 expression, closely resembling perinatal nicotine exposure-mediated effects. Locked nucleic acid (LNA)-miR-181a antisense reversed perinatal nicotine-mediated increase in H/I-induced brain injury and normalized aberrant ATG5 expression. In addition, nicotine exposure attenuated a long non-coding RNA (lncRNA) H19 expression level. Knockdown of H19 via siRNA increased the miR-181a level and enhanced H/I-induced neonatal brain injury. In conclusion, the present findings provide a novel mechanism that aberrant alteration of the H19/miR-181a/AGT5 axis plays a vital role in perinatal nicotine exposure-mediated ischemia-sensitive phenotype in offspring and suggests promising molecular targets for intervention and rescuing nicotine-induced adverse programming effects in offspring.     

车灯座注塑模具设计

通过对车灯座注塑模具的设计,阐述了模具浇注系统的设计方法,旨在降低模具的复杂程度和制造成本;详细介绍了组合式型腔、型芯的结构设计及模具的制造方法。     

Al4B2O9纳米棒改性制备优异综合性能的固体聚合物电解质

随着储能设备和电力驱动产品的激增,特别是电动汽车的大规模推广应用,全固态电池被认为是最有可能解决电动设备日益严峻的安全问题和高能量密度需求的策略之一.本文报道了一种Al4B2O9纳米棒改性的聚环氧乙烷(PEO)基固体聚合物电解质(ASPE),其具有高离子电导率、宽电化学窗口、良好的机械性能和阻燃性能.具体来说,因为Al...     

Systematic adsorption process of petroleum hydrocarbon by immobilised petroleum-degradation bacteria system in degradation pathways

In order to effectively control petroleum hydrocarbon pollution by immobilisation technology,it is necessary to understanding the degradation pathways of petrol...     

Velocity and turbulence characteristics in an open channel with multi-row staggered vegetation patches

A staggered distribution of vegetation is very common in nature,which might significantly affect the flow structure.To investigate its impact,three rows of stag...     

在结冰状态下一次设备闪络事故分析

介绍了玉贤变电站500 kV电流互感器的冰闪事故情况,分析事故的原因为瓷瓶表面纵向结冰不均匀引起径向电位差使外绝缘闪络。提出采用增爬裙能有效阻断冰桥。     

直流滤波器电容器的直流局部放电测量

为了配合葛州坝换流站直流滤波器电容器的损坏事故分析,进行了电容器常温和高温状态,直流电压作用下的局部放电试验。在常温和高温状态下,分别用双臂式抗干扰回路,和微窗口电路,有效地抑制了外部干扰。测量结果表明,电容器在高温状态下的直流局部放电量较常温下没有显著增加。文中还对电容器直流局部放电测量时所应注意的问题进行了讨论。