An empirical molecular docking study of a di-iron binding protein with iron ions

Various molecular docking software packages are available for modeling interactions between small molecules and proteins.However,there have been few reports of modeling the interactions between metal ions and metalloproteins.In this study,the AutoDock package was employed to example docking into a di-iron binding protein,bacterioferritin.Each binding site of this protein was tested for docking with iron ions.Blind docking experiments showed that all docking conformations converged into two clusters,one for internal iron binding in sites within the metalloprotein and the other for external iron binding on the protein surface.Local docking experiments showed that there were significant differences between two internal iron binding sites.Docking at one site gave a reasonable root-mean-square deviation(RMSD) distribution with relatively low binding energy.Analysis of the binding mode quality for this site revealed that more than half of the docking conformations were categorized as having good binding geometry,while no good conformations were found for the other site.Further investigations indicated that coordinating water molecules contributed to the stability of binding geometries.This study provides an empirical approach towards the study of molecular docking in metalloproteins.     

光学薄膜元器件外观特性机器视觉检测系统

本系统利用工业级摄像头及开发包的机器视觉功能与计算软件编程控制技术相结合,通过与输入控制系统中的标准膜片模板外观品质进行对比,实现高速高效、准确识别检测光学薄膜器件中滤光片的外观缺陷。可在生产线上根据外观品质标准模板中设定的类别进行自动分类装盒。     

UDP协议在视频图像传输中的扩展与应用

根据UDP协议的特点,结合视频网络传输的要求对其进行扩展,给UDP数据包定义了一个8个字节的包头结构,用来加载数据包的序列号、时戳等信息。在发送端对传榆进行平滑处理,控制数据包大小和时戳间隔,减小了图像抖动的发生。应用给出了一种在Delphi下实现的视频数据打包流程,能够满足多种网络平台上的视频传输的要求。     

Truth-Telling Reservations

We present a mechanism for reservations of bursty resources that is both truthful and robust. It consists of option contracts whose pricing structure induces users to reveal the true likelihoods that they will purchase a given resource. Users are also allowed to adjust their options as their likelihood changes. This scheme helps users save cost and the providers to plan ahead so as to reduce the risk of under-utilization and overbooking. The mechanism extracts revenue similar to that of a monopoly provider practicing temporal pricing discrimination with a user population whose preference distribution is known in advance.     

使用HTTP Tunneling技术实现穿透网络防火墙的通信

近年来,防火墙在网络中得到了广泛的应用.它能够比较有效地防范病毒与黑客的攻击,保护网络的安全.但是也带来了一些不利影响,使一些需要进行网络通信的应用软件系统不能正常工作.介绍一个解决方案,并且重点介绍通过HTTP Tunneling技术使用基于文本的HTTP协议传送二进制数据的方法.     

高集成RDS调频收音模块设计

主要介绍基于便携式设备的RDS调频收音模块的设计,着重讲述了有关FM接收、RDS数据接收与音频处理等方面的应用电路。     

In Situ Polymerizing Internal Encapsulation Strategy Enables Stable Perovskite Solar Cells toward Lead Leakage Suppression

Despite the outstanding power conversion efficiency (PCE) of perovskite solar cells (PSCs) achieved over the years, unsatisfactory stability and lead toxicity remain obstacles that limit their competitiveness and large-scale practical deployment. In this study, in situ polymerizing internal encapsulation (IPIE) is developed as a holistic approach to overcome these challenges. The uniform polymer internal package layer constructed by thermally triggered cross-linkable monomers not only solidifies the ionic perovskite crystalline by strong electron-withdrawing/donating chemical sites, but also acts as a water penetration and ion migration barrier to prolong shelf life under harsh environments. The optimized MAPbI₃ and FAPbI₃ devices with IPIE treatment yield impressive efficiencies of 22.29% and 24.12%, respectively, accompanied by remarkably enhanced environmental and mechanical stabilities. In addition, toxic water-soluble lead leakage is minimized by the synergetic effect of the physical encapsulation wall and chemical chelation conferred by the IPIE. Hence, this strategy provides a feasible route for preparing efficient, stable, and eco-friendly PSCs.     

Lightweight deep learning methods for panoramic dental X-ray image segmentation

Neural Computing and Applications - Dental X-ray image segmentation is helpful for assisting clinicians to examine tooth conditions and identify dental diseases. Fast and lightweight segmentation...     

Semi-supervised transformable architecture search for feature distillation

Pattern Analysis and Applications - The designed method aims to perform image classification tasks efficiently and accurately. Different from the traditional CNN-based image classification methods,...