Intracoronary infusion of E6010 has more potent thrombolytic activity than tissue plasminogen activator (t-PA) in dogs: a higher plasma level of E6010 than t-PA causes potent thrombolytic activity

We examined the thrombolytic properties of a novel modified human tissue plasminogen activator (PA) (E6010), in which cysteine 84 is replaced by serine, and which has a prolonged biologic half-life (t1/2). We compared the thrombolytic efficacy of continuous intracoronary (i.c.) infusion of E6010 with that of recombinant human tissue PA (rt-PA) in a canine model with copper coil-induced 1-h-old coronary artery thrombi and also compared the relation between thrombolytic efficacy and plasma clearance represented by pharmacokinetic parameters of i.c.-infused E6010 and rt-PA. Sixty-minute E6010 and rt-PA i.c. infusions were compared. The thrombolytic effects of i.c.-infused E6010 and rt-PA, represented by time to reperfusion (TR), reperfusion rate at 60 min (RR), and reocclusion rates at 60 min after reperfusion (OR) were as follows. E6010: Dose 0.06, 0.15, 0.3 (mg/kg/h); TR 25 +/- 10, 15 +/- 10, 13 +/- 5 (min); RR 100, 100, 100 (%); and OR 0, 0, 17 (%), respectively. Recombinant t-PA: Dose 0.06, 0.15, 0.3 (mg/kg/h); TR 47 +/- 12, 18 +/- 17, 14 +/- 4 (min); RR 50, 75, 100 (%); and OR 100, 33, 33 (%), respectively. These findings indicate that E6010 has more potent thrombolytic activity than rt-PA.(ABSTRACT TRUNCATED AT 250 WORDS)     

Handling of fine-particles by time-averaged particle driving method in plasmas

We developed a noble technique for the fine-particle handling in plasmas. In this method a pair of point electrodes are introduced in the plasma, to which positive pulses are applied alternatively. When the pulse repetition period is shorter than the particle response time, the particles feel only time-averaged force because of their large mass. Spatial profile of the equivalent potential of the time-averaged force varies from a circle to an ellipse with an increase in the local discharge at the electrodes. The particles are eventually transported toward a middle point between two point-electrodes, being almost independent of their initial positions. This method is quite effective for converging fine particles in the plasma.     

Improved ADPCM voice signal transmission employing click-noisedetection scheme for TDMA-TDD personal communication systems

In personal communication systems, better voice quality and lower terminal price are essential requirements, and adaptive differential pulse-code modulation (ADPCM) codecs are one of the voice codec candidates that have good voice quality and reasonable cost. However, in slow fading environments, burst errors induce click noise in ADPCM voice signal transmission. This paper proposes a novel error-concealment scheme to improve the ADPCM voice signal transmission quality of time division multiple access time division duplex (TDMA-TDD) personal communication systems in slow fading environments. The proposed scheme employs an improved error-detection technique with PCM differential detection and overflow detection coupled with a cyclic redundancy check (CRC) code. To compensate for residual click noise, an expanded CRC error-detection signal is used. Erroneous PCM signals are adaptively suppressed according to the click-noise detection information. Hardware simulation results show that these techniques significantly improve ADPCM voice signal transmission quality by 0.5 points and 1.0 compared to that of the conventional ADPCM muting scheme and no processing, respectively, with the mean opinion scoring (MOS) test in the slow fading environments typical of personal communication systems     

Twin-Related Tetragonal Variants in Yttria Partially Stabilized Zirconia

Crystals of yttria partially stabilized zirconia were grown by the arc-image floating-zone technique and studied by transmission electron microscopy. Crystals annealed at 1700°C consist of tetragonal precipitates and a cubic matrix. The platelike domains in a precipitate are twin-related tetragonal variants stacked alternately parallel to the (011) twin plane. The axial relations between the tetragonal precipitate and the cubic matrix are [100]_tetragonal|[100]_cubic, [011]_tetragonal|[011]_cubic.     

Tunable UV generation to 0.185 μm inCsB3O5

CsB₃O₅ has been found to be phase matchable for SFG down to 0.185 μm by mixing the fifth harmonic of a Nd:YAG laser at 1.0642 μm and the output of a KTP parametric oscillator pumped by the second harmonic of the same Nd:YAG laser at 20.0°C. Improved Sellmeier's equations and nonlinear optical constant of this crystal are reported     

Multivariate analysis of the associations between laboratory data and clinical features among patients with infectious mononucleosis syndrome

Infectious mononucleosis (IM) syndrome is typically caused by EBV, but also by drugs and other organisms such as CMV and HBV. It demonstrates a wide range of clinical and laboratory characteristics, presumably depending on the age of onset. However, associations of laboratory abnormalities with the clinical features have not been well documented. We evaluated here, the associations among patients with IM syndrome using of multiple regression (MR) and multiple logistic regression (MLR) analyses. We examined 90 (40 males, 50 females) patients, who were admitted to our hospital with IM syndrome. The diagnostic criteria were fever and presence of atypical lymphocytes (> 5% of the WBC or the count including monocytes > 5000/microliter), and at least 3 of 7 clinical features: tonsillitis, lymphadenopathy, skin rash, hepato-, spleno-megaly, hepatic dysfunction. The diagnosis of EBV was serologically confirmed in 41 cases. MR revealed that the higher age group tended to have lower platelet counts, and that lower platelet counts were associated with higher ALT levels. In addition, MLR revealed that patients with skin rash tended not to have splenomegaly. The frequency of splenomegaly was not related to age, contrary to the findings of previous reports. These findings are useful to differentiate IM syndrome based on laboratory data.     

Inhibition by dexamethasone of human neutrophil apoptosis in vitro

The efficacy of collagen-sponge to reduce postoperative scar formation was investigated in 65 Japanese white rabbits that received laminectomy in the 7th and 8th thoracic vertebra. The defect after laminectomy was filled by collagen-sponge in 25 rabbits, by free fat in 20 rabbits, and by nothing in 20 rabbits as controls. The animals were sacrificed 2, 4, 8 and 12 weeks and additional 5 rabbits of which defects were filled with collagen-sponge were sacrificed after 24 weeks. All the defects were examined histologically. At 4 weeks after laminectomy, the defects filled by collagen-sponge showed that fibrous tissue had invaded into the sponge, but there was no remarkable adhesion to the dura mater. At 8 weeks, the defect with collagen sponge showed foaming cells, and no thickening of the dura mater was observed. At 12 weeks, the grouping of foaming cells was partially replaced by fat cells. At 24 weeks, most of the foaming cells were replaced by fat cells, and the defect was then similar to that filled by free fat at 12 weeks. In contrast, the defect with no interposed membrane was already filled with fibrous tissue at 4 weeks, and adhesion to the dura mater was observed. Although the free-fat graft at 12 weeks postoperatively showed no remarkable adhesion around the dura mater, infiltration of fat tissue into the spinal canal was observed in 2 of 5 rabbits. These results indicated that collagen-sponge can be utilized as a new biomaterial to effectively prevent scar formation after laminectomy.     

Preparation of spherical fine ZnO particles by the spray pyrolysis method using ultrasonic atomization techniques

An ultrasonic atomizer was used in the spray pyrolysis method to prepare fine, spherical and uniform ZnO particles. Almost spherical particles were obtained successfully which had a mean particle size of 0.15 m and had a very narrow particle size distribution. By using alcohol as the solvent, it was found that the particles do not have hollow shell layers which could usually be observed in the spray pyrolysis process by using water as the solvent. The morphology of the ZnO particles was strongly affected by the concentration of the starting solution.     

Formation of monodispersed Ta2O5 powders

The Ta₂O₅ powders synthesized by the hydrolysis of tantalum pentaethoxide, Ta(OC₂H₅)₅ in alcoholic solution were monodispersed fine oxide particles, which were a uniform, spherical shape, non-agglomerate, and had a narrow size distribution. They grew to 1.2m after ageing for 1 h after hydrolysis. Powder X-ray diffraction and differential thermal analysisthermogravimetric analysis showed the particles were amorphous and hydrated. These particles lost the water at 290° C and gave well-crystalline Ta₂O at 740° C. Throughout these thermal processes, the particle morphology was kept almost the same.