Hyperdynamic circulation of cirrhotic rats: role of substance P and its relationship to nitric oxide

BACKGROUND: It has been suggested that excessive formation of nitric oxide (NO) is responsible for the hyperdynamic circulation observed in portal hypertension. Substance P is a neuropeptide partly cleared by the liver and causes vasodilatation through the activation of the endothelial NO pathway. However, there are no previously published data concerning the plasma level of substance P in cirrhotic rats and its relationship to NO. METHODS: Plasma concentrations of substance P and nitrate/nitrite (an index of NO production) were determined in control rats and cirrhotic rats with or without ascites using an enzyme-linked immununosorbent assay and a colorimetric assay, respectively. In addition, systemic and portal hemodynamics were evaluated by a thermodilution technique and catheterization. RESULTS: Cirrhotic rats with and without ascites had a lower systemic vascular resistance (2.6 +/- 0.2 and 3.9 +/- 0.4 mmHg ml(-1) x min x 100 g body weight, respectively) and higher portal pressure (14.6 +/- 0.6 and 11.3 +/- 1.8 mmHg) than control rats (6.5 +/- 0.3 mmHg x ml(-1) x min x 100 g BW and 6.8 +/- 0.2 mmHg, respectively, P < 0.05), and cirrhotic rats with ascites had the lowest systemic vascular resistance. Plasma levels of nitrate/nitrite progressively increased in relation to the severity of liver dysfunction (control rats, 2.7 +/- 0.5 nmol/ml; cirrhotic rats without ascites, 5.6 +/- 1.3 nmol/ml; cirrhotic rats with ascites, 8.3 +/- 2.2 nmol/ml; P < 0.05). Cirrhotic rats with ascites displayed higher plasma values of substance P (57.7 +/- 5.9 pg/ml) than cirrhotic rats without ascites (37.9 +/- 3.1 pg/ml, P < 0.05) and control rats (30.1 +/- 1.0 pg/ml, P < 0.05). There was no significant difference in plasma substance P values between control rats and cirrhotic rats without ascites (P > 0.05). No correlation was found between plasma levels of substance P and nitrate/nitrite (r = 0.318, P > 0.05). CONCLUSIONS: Excessive formation of NO may be responsible, at least partly, for the hemodynamic derangements in cirrhosis. Although substance P may not participate in the initiation of a hyperdynamic circulation in cirrhosis, it may contribute to the maintenance of the hyperdynamic circulation observed in cirrhotic rats with ascites.     

定向爆破拆除高危烟囱的实践

通过对已产生纵向裂缝、倾斜和基部风化剥蚀严重的高危烟囱的定向（向倾斜相反方向）倒塌爆破实践表明：设计中选用爆破参数及施工措施是有效的。     

Error monitoring issues for common channel signaling

Motivated by field data which showed a large number of link changeovers and incidences of link oscillations between in-service and out-of-service states in common channel signalling (CCS) networks, a number of analyses of the link error monitoring procedures in the SS7 protocol were performed by the authors. This paper summarizes the results obtained thus far and include the following: (a) results of an exact analysis of the performance of the error monitoring procedures under both random and bursty errors; (b) a demonstration that there exists a range of error rates within which the error monitoring procedures of SS7 may induce frequent changeovers and changebacks; (c) an analysis of the performance of the SS7 level-2 transmission protocol to determine the tolerable error rates within which the delay requirements can be met; (d) a demonstration that the tolerable error rate depends strongly on various link and traffic characteristics, thereby implying that a single set of error monitor parameters will not work well in all situations; and (e) some recommendations on a customizable/adaptable scheme of error monitoring with a discussion on their implementability. These issues may be particularly relevant in the presence of anticipated increases in SS7 traffic due to widespread deployment of advanced intelligent network (AIN) and personal communications service (PCS) as well as for developing procedures for high-speed SS7 links currently under consideration by standards bodies     

火烧山原油破乳剂的筛选与应用

介绍了火烧山原油的物性与破乳剂结构和配比的关系、TA1031破乳剂的室内脱水评价及性能特点、TA1031的现场应用效果、破乳剂现场用药量与室内最佳用药量的关系、原油现场脱水过程中破乳剂用药量与污水含油的关系。     

浅谈实验室检验在科研生产中的作用

文章阐述了实验窀检验在科研生产中的作用及发挥作用的巨大潜力。     

Analytical solution for the axisymmetric plane strain electroelastic dynamics of a special non-homogeneous piezoelectric hollow cylinder

By virtue of the introduction of a dependent variable and the separation of variables technique, the axisymmetric plane strain electroelastic dynamic problem of a special non-homogeneous piezoelectric hollow cylinder is transformed to a Volterra integral equation of the second kind about a function with respect to time, which can be solved successfully by means of the interpolation method. Then the solutions of displacements, stresses, electric displacements and electric potential are obtained. The present method is suitable for a piezoelectric hollow cylinder with an arbitrary thickness subjected to arbitrary mechanical and electrical loads. Numerical results are finally presented.     

参数强迫激励下非线性振子尖点型奇点的分叉

本文首先研究了不具有Z_2—对称性时的规范形理论和退化向量场的普适开折理论。然后利用这些理论研究了参数激励与强迫激励联合作用下非线性振动系统的尖点型奇点的余维2退化分叉。     

略论贵州省化工企业职业教育的发展

从目前市场需求和就业率出发，进行形势分析，提出优化专业设置、加强实践环节、提高高职学院办学层次、推进“双证书”制度等改革方法，以促进化工职业教育的发展。     

油基钻井液的推广及循环利用

针对普通水基钻井液在钻进中强、强水敏性油藏时会造成储层污染、产量降低的问题,指出了油基钻井液在钻进该类油藏时的优势和其成本高、对生态环境有污染的缺点。为了大面积推广应用油基钻井液,重点介绍了油基钻井液的特性和稳定性影响因素,并通过室内评价证明了油基钻井液在油层保护中的良好效果,着重阐述了油基钻井液在王庄油田的现场应用情况,并探讨了油基钻井液的循环利用技术。研究结果表明,油基钻井液不仅具有良好的油层保护效果,而且具有较好的社会经济效益。