Ornithine decarboxylase transformation of NIH/3T3 cells is mediated by altered epidermal growth factor receptor activity

Ornithine decarboxylase (ODC) has been shown to be oncogenic in transfected NIH/3T3 cells overexpressing the enzyme from a heterologous promoter. These cells, designated as NODC-2 cells, acquire proliferative properties associated with tumorigenic transformation such as loss of contact inhibition, decreased population doubling time, anchorage-independent growth, and tumor production in nude mice. At least one of these parameters, loss of contact inhibition, remains dependent on elevated ODC levels. We have used these cells to investigate the molecular mechanisms by which ODC overexpression drives cell transformation and to examine the involvement of other proto-oncogene products in this process. An interaction between ODC overexpression and the epidermal growth factor receptor (EGF-R) was suggested initially by the elevation of both basal (300%) and ligand-induced (457%) EGF-R tyrosine kinase activities in NODC-2 cells compared to similarly treated control NLK cells. Disruption of EGF-R mediated signal transduction in NODC-2 cells both by treatment with tyrphostin-25 or by transfection with a vector expressing a dominant negative EGF-R mutant resulted in reacquisition of contact-inhibited growth and suppression of anchorage-independent, clonogenic growth in soft agar. We conclude that ODC-induced transformation of NIH/3T3 cells is mediated, at least partly, by alterations in EGF-R signal transduction activity.     

无线局域网中基于RC4的加密算法的分析与改进

分析RC4加密算法自身的缺陷和无线局域网WEP协议对RC4的误用,介绍了TKIP协议在安全性方面的改进。     

基于数字图像分析的薄板成形应变场测量方法

对薄板成形应变场传统的测量方法进行了研究。指出了其不足和误差的来源，提出了数字图像分析法测量薄板成形中的应变场，对测量原理，新的测量方法对传统方法的改进，以及如何降低误差进行了介绍，指出数字图像分析法的前景，提出了改进意见。     

Promising alloys for intermediate-temperature solid oxide fuel cell interconnect application

The formation of a low Cr-volatility and electrically conductive oxide outer layer atop an inner chromia layer via thermal oxidation is highly desirable for preventing chromium evaporation from solid oxide fuel cell (SOFC) metallic interconnects at the SOFC operation temperatures. In this paper, a number of ferritic Fe–22Cr alloys with different levels of Mn and Ti as well as a Ni-based alloy Haynes 242 were cyclically oxidized in air at 800 °C for twenty 100-h cycles. No oxide scale spallation was observed during thermal cycling for any of these alloys. A mixed Mn₂O₃/TiO₂ surface layer and/or a (Mn, Cr)₃O₄ spinel outer layer atop a Cr₂O₃ inner layer was formed for the Fe–22Cr series alloys, while an NiO outer layer with a Cr₂O₃ inner layer was developed for Haynes 242 after cyclic oxidation. For the Fe–22Cr series alloys, the effects of Mn and Ti contents as well as alloy purity on the oxidation resistance and scale area specific resistance were evaluated. The performance of the ferritic alloys was compared with that of Haynes 242. The mismatch in thermal expansion coefficient between the different layers in the oxide scale was identified as a potential concern for these otherwise promising alloys.     

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本文根据灰色系统理论中的灰色决策原理,提出了一种合理选择钻机的新方法,并通过了实例验证。结果表明,这种方法切实可行。     

疏水缔合型聚丙烯酰胺的合成与性能评价

为了提高高相对分子质量的聚丙烯酰胺的抗温抗盐性能,利用自制的两亲表面活性单体与丙烯酰胺共聚合成了疏水缔合型聚丙烯酰胺并进行室内评价。结果表明,在高温、高盐、高钙条件下,合成的疏水缔合型聚丙烯酰胺具有良好的增粘性和较强的热稳定性;克服了疏水缔合型聚合物在盐水中溶解性差的问题,可用各种矿化度的盐水和油田产出污水配制;具有良好的无机盐增粘性能和抗温性能。     

35t/h循环流化床锅炉技术改造

该文分析了国家庄煤矿电厂35t/h循环流化床锅炉存在的问题，提出了技术改造方案和措施。     

文东油田连续气举优化配气数学模型建立及应用

针对连续气举在开发过程中出现的注入气利用效率低、综合效益差的问题，建立了供气能力有限时的优化配气数学模型，给出了解析法求解过程。文东油田现场试验表明，应用该技术可以实现连续气举井的合理配气，并提高油井产量，适合在油田推广应用。     

面向智能计算的记忆结构理论综述

本文从智能计算角度出发，对记忆的总体结构、信息表征及记忆模型等方面的理论作一综述。并在分析、比较了这些理论与ＡＩ中的相关理论差异的基础上，对面向智能计算的记忆理论研究方法与方向作了扼要讨论。