Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism

As the most recent melanocortin receptor (MCR) identified, melanocortin-5 receptor (MC5R) has unique tissue expression patterns, pharmacological properties, and physiological functions. Different from the other four MCR subtypes, MC5R is widely distributed in both the central nervous system and peripheral tissues and is associated with multiple functions. MC5R in sebaceous and preputial glands regulates lipid production and sexual behavior, respectively. MC5R expressed in immune cells is involved in immunomodulation. Among the five MCRs, MC5R is the predominant subtype expressed in skeletal muscle and white adipose tissue, tissues critical for energy metabolism. Activated MC5R triggers lipid mobilization in adipocytes and glucose uptake in skeletal muscle. Therefore, MC5R is a potential target for treating patients with obesity and diabetes mellitus. Melanocortin-2 receptor accessory proteins can modulate the cell surface expression, dimerization, and pharmacology of MC5R. This minireview summarizes the molecular and pharmacological properties of MC5R and highlights the progress made on MC5R in energy metabolism. We poInt. out knowledge gaps that need to be explored in the future.     

Open-circuit fault detection for three-phase inverter based on backpropagation neural network

Neural Computing and Applications - To realize real-time fault detection in power devices and enhance reliability of inverter circuits, this paper proposes a detection method based on Park’s...     

需求管理及配置管理与项目范围管理

需求管理、配置管理和项目范围管理在软件项目管理中具有重要的地位和作用。透彻分析了需求管理、配置管理和项目范围管理知识理论中的基本概念,有助于形成对需求管理、配置管理和项目范围管理的深刻理解,有利于规范和促进日常项目管理工作。     

某铀矿井场抽注液控制的数字化技术应用

在地浸采铀生产过程中,控制抽注液平衡和高效识别抽注液异常状态是保障浸出效能和井场的安全重要措施。以内蒙古某铀矿为例,介绍了该铀矿抽注液平衡联动控制与抽注液异常监测方面数字化技术的应用情况,探讨了应用数字化技术前后该铀矿山抽注液管控效能的变化。结果表明,应用数字化技术进行抽注液平衡控制能有效解决抽注液调控过程中人工控制所存在的劳动强度大、调控不及时和精度不足的问题;合理的模型设计能够高效识别抽注液异常状态。建立抽注液数字化管控体系有助于实现精益化管控、提升井场生产效能、降低安全风险。     

贵州电网输电线路在线监测系统运行分析

通过介绍贵州电网输电线路在线监测系统的应用和运行情况,对系统在运行过程中发生的缺陷和故障进行了统计和梳理,通过对故障原因的分析,提出了相应的改进对策。     

Influence of hexapod robot foot shape on sinking considering multibody dynamics

Journal of Mechanical Science and Technology - Hexapod robots have attracted attention for their excellent terrain adaptabilities. When a robot walks on soft soil, dynamic subsidence and slippage...     

Green cell association for multimedia transmission in cognitive heterogeneous networks

With the introduction of low‐powered pico/femto‐base stations and relay nodes into the macro‐cell, recent heterogeneous networks provide an attractive approach for future wireless communication. Although it may achieve better coverage and higher capacity, several problems remain unsolved before practical deployment. For example, how to select the proper cell from neighbor low‐powered cells and then occupy the radio resource without interference on macro‐users is both important and challenging, especially for rigorous multimedia applications. The traditional cell access algorithms and quality‐control parameters such as delay or throughput no longer suit well in this complex environment. An effective approach should be pursued. In this paper, we investigate this interesting cell association problem and propose a complete green resolution on the basis of thorough discussions about the multimedia transmission under these concerns. Cognitive radio is introduced to share spectrum between macro‐cell and low‐powered cells while securing the transmission of authorized macro‐users. We also bring forth the concept of ‘interference balance’ to better manage the overall interference and energy consumption in the network. Restless bandit model is formulated on the basis of channel state, data rate, interference control, and the carefully chosen intra‐refreshing rate for multimedia traffic. Then the cell association scheme is designed to be efficient and practical because of the simple index property of our model output. Simulation results have proven the performance of our proposed resolution compared with existing algorithms on interference constraint, multimedia distortion, and overall network energy consumption balance. Copyright © 2013 John Wiley & Sons, Ltd.     

蛋类膜-壳结构启发制备兼具高灵敏度和宽检测范围的应变传感

为了解决可拉伸应变传感器的灵敏度与检测范围(最大和最小可拉伸性)之间相互制约的问题.受蛋类膜-壳结构的启发,本文提出了一种构筑具有高灵敏度、宽可拉伸应变传感器的新策略,即基于柔性可拉伸的表面接枝聚吡咯膜(s-PPy)(类似于蛋膜)和脆性金膜(类似于蛋壳)制备器件.Au和s-PPy膜在电学和机械性能上产生相互协同作用.A...     

煤基高性能炭素材料在建筑中的应用

煤基高性能炭素材料普遍具有稳定性号、耐腐蚀、绝缘等性能特点,有助于建筑工程质量的提高。结合常见的煤基高性能炭素材料性能,并对其在建筑工程中的应用进行深入分析。     

拖拉机驾驶员考试系统的研制

通过对拖拉机驾驶员考试系统的工作原理、系统组成、试验研究及系统软件的论述,阐明了该考试系统在农机安全管理中的重要作用.