Physics-Informed Multistage Machine Learning Strategy for the Nanomachining-Induced Plastic Deformation Behavior

The evolution of the dislocation density induced by the nanomachining process dominates the plastic deformation behaviors of materials, thus affecting the mechanical properties significantly. However, a challenging topic related to how to establish an accurate model for predicting the dislocation density based on the limited simulations and experiments arises due to the complicated thermal–mechanical coupling mechanism during the machining process. Herein, a multistage method integrating machine learning, physics, and high-throughput atomic simulation is proposed to investigate the effect of cutting speed on the dislocation behavior in polycrystal copper. Compared with the traditional one-step machine learning method, the constraint of physical features effectively improves the accuracy and generalization ability of the model. The results indicate that the dislocation behaviors depend on the competition between the cutting force and temperature. In the low-cutting speed, the predominated role of the cutting temperature leads to a rapid decline of the dislocation density. In contrast, the dislocation density tends to be stable under a high-speed cutting process due to the dynamic balance between the effects of the cutting force and temperature. Notably, the proposed strategy provides a new and universal framework to design the machining parameters to obtain high-quality products.     

Peptidyl Virus-Like Nanovesicles as Reconfigurable “Trojan Horse” for Targeted siRNA Delivery and Synergistic Inhibition of Cancer Cells

The self-assembly of peptidyl virus-like nanovesicles (pVLNs) composed of highly ordered peptide bilayer membranes that encapsulate the small interfering RNA (siRNA) is reported. The targeting and enzyme-responsive sequences on the bilayer's surface allow the pVLNs to enter cancer cells with high efficiency and control the release of genetic drugs in response to the subcellular environment. By transforming its structure in response to the highly expressed enzyme matrix metalloproteinase 7 (MMP-7) in cancer cells, it helps the siRNA escape from the lysosomes, resulting in a final silencing efficiency of 92%. Moreover, the pVLNs can serve as reconfigurable “Trojan horse” by transforming into membranes triggered by the MMP-7 and disrupting the cytoplasmic structure, thereby achieving synergistic anticancer effects and 96% cancer cell mortality with little damage to normal cells. The pVLNs benefit from their biocompatibility, targeting, and enzyme responsiveness, making them a promising platform for gene therapy and anticancer therapy.     

Study of delay-independent decentralized guaranteed cost control for large scale systems

This study introduces delay independent decentralized guaranteed cost control design method based on two controller structures for nonlinear uncertain interconnected large scale systems with time delays. First, a set of equivalent Takagi-Sugeno (T-S) fuzzy models are extended to represent the systems. Then a decentralized state-feedback guaranteed cost performance controller is proposed for the fuzzy systems. Based on delay independent Lyapunov functional approach, some sufficient conditions for the existence of the controller can be cast into the feasible problem of LMIs irrespective of the sizes of the time delays so that the system can be asymptotically stabilized for all considered uncertainties whose sizes are not larger than their bounds. Finally, the minimizing approach is proposed to search the suboptimal upper bound value of guaranteed cost function. Moreover, the corresponding conditions are extended into the generalized dynamic output-feedback close-loop system. Finally, the better control performances of the proposed methods are shown by the simulation examples.     

Will the experience of playing a violent role in a video game influence people’s judgments of violent crimes?

The present study investigates the impact of the experience of role playing a violent character in a video game on attitudes towards violent crimes and criminals. People who played the violent game were found to be more acceptable of crimes and criminals compared to people who did not play the violent game. More importantly, interaction effects were found such that people were more acceptable of crimes and criminals outside the game if the criminals were matched with the role they played in the game and the criminal actions were similar to the activities they perpetrated during the game. The results indicate that people’s virtual experience through role-playing games can influence their attitudes and judgments of similar real-life crimes, especially if the crimes are similar to what they conducted while playing games. Theoretical and practical implications are discussed.     

Array SSL VPN如何保障番禺有线办公网的安全运行

企业办公自动化系统的应用十分广泛,随着互联网的高速发展,WEB应用成为主流,OA系统在互联网上的延伸成为大趋势,本文阐述在WEB应用中如何保障数据和系统安全的手段和方法。     

A two-level strategy for segmenting center of interest from pictures

Segmenting center of interests (COIs) from pictures is an important but highly challenging problem for researchers in computer vision and image processing. The capability of understanding the meanings of pictures by computers can lead to breakthroughs in a wide range of applications including Web image search and online picture-sharing communities. In this paper, a two-level strategy is presented, which consists of a rough segmentation stage and a fine segmentation stage. In the first level, a picture is partitioned into four regions by using a block clustering method based on color and texture features, and the COI within the picture is distinguished from the background according to the principles of photographic composition. This stage aims to determine the approximate region of the target. In the second level, a novel active contour model is established based on shape information and vector method, where the image energy is defined by a hue gradient and the external energy is generated from either a triangular inner force or a supplementary force. This stage tries to extract the boundary of the target accurately. Experimental results on photos downloaded from the Internet show the feasibility and effectiveness of the proposed method.     

Tuning of multi-loop PI controllers based on gain and phase margin specifications

In this paper, a single-iteration strategy is proposed for the design of a multi-loop PI controller to achieve the desired gain and phase margins for two-input and two-output (TITO) processes. To handle loop interactions, a TITO system is converted into two equivalent single loops with uncertainties drawn from interactions. The maximum uncertainty is estimated for the initial controller design in one loop and single-input and single-output (SISO) controller design is applied. This controller is substituted to other equivalent loop for design, and finally, the first loop controller is refined on knowledge of other loop controller. For SISO controller tuning, a new method is presented to determine the achievable gain and phase margins as well as the relevant controller parameters. Examples are given for illustration and comparison.     

混沌权值变异的Huffman树图像加密算法

提出一种采用混沌权值变异的Huff man树的图像加密算法.此算法在熵编码过程中,以基本的Huffman树为标准,利用双耦合混沌序列1对DC系数进行树的结构未变异、路径值变异的加密;再利用双耦合混沌序列2对AC系数进行码字序号的加密.论文对算法进行了仿真,并对安全性、计算复杂度、压缩比性能进行了分析.实验结果表明,该算法基本上不影响压缩效率,且计算复杂度低、安全性高和实时性好,可用于网络上的图像服务.     

Nanotextured superhydrophobic micromesh

A superhydrophobic micromesh covered with nanoprotrusions has been introduced and its applicability to a waterproof mobile phone speaker has been evaluated. The nanotextured superhydrophobic micromesh showed excellent water repellency, self-cleaning and waterproofing performances. In a waterproof speaker test using the fabricated nanotextured micromesh, the micromesh did not lose its waterproof function at 2 m water depth and did not form a remnant water film after being removed from the water. The packaged speaker showed almost the same sound quality before and after dipping at a 2 m water depth. These results demonstrate that the superhydrophobic nanotextured micromesh could be directly applicable for various products that need to resist water penetration, yet allow the transmission of gases and sound/light waves.