Unkeito Suppresses RANKL-Mediated Osteoclastogenesis via the Blimp1–Bcl6 and NF-κB Signaling Pathways and Enhancing Osteoclast Apoptosis

Osteoporosis is a common bone disease, particularly in menopausal women. Herein, we screened four Kampo medicines (Unkeito (UKT), Kamishoyosan (KSS), Kamikihito (KKT), and Ninjinyoeito (NYT)), frequently used to treat menopausal syndromes, for their effects on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation in RAW 264 cells. Considering that UKT exhibited the most potent effect, we examined its effect on RANKL-induced osteoclastogenesis, the induction of osteoclast apoptosis, and the mechanisms underlying its effects. UKT inhibits RANKL-induced osteoclast differentiation in the early stage and decreases osteoclast-related genes, including tartrate-resistant acid phosphatase (Trap), dendritic cell-specific transmembrane protein (Dcstamp), matrix metalloproteinase-9 (Mmp9), and cathepsin K (Ctsk). Specifically, UKT inhibits the nuclear factor of activated T cells 1 (NFATc1), which is essential for osteoclastogenesis. UKT increases Bcl6, which antagonizes NFATc1 and Dc-stamp, thereby blocking the progression of osteoclasts to maturation. UKT also decreased nuclear translocation by downregulating the activity of p65/NF-κB. In addition, UKT enhances mononuclear osteoclast apoptosis via activation of caspase-3. Herein, we demonstrate that UKT suppresses RANKL-mediated osteoclastogenesis via the Blimp1–Bcl6 and NF-κB signaling pathways and enhances mononuclear osteoclast apoptosis. Furthermore, UKT prevents bone loss in OVX mice. Thus, UKT might be a potential therapeutic agent for postmenopausal osteoporosis.     

Hierarchical Magnetic Network Constructed by CoFe Nanoparticles Suspended Within “Tubes on Rods” Matrix Toward Enhanced Microwave Absorption

Hierarchical magnetic-dielectric composites are promising functional materials with prospective applications in microwave absorption(MA)field.Herein,a three-dimension hierarchical“nanotubes on microrods,”core–shell magnetic metal–carbon composite is rationally constructed for the first time via a fast metal–organic frameworksbased ligand exchange strategy followed by a carbonization treatment with melamine.Abundant magnetic CoFe nanoparticles are embedded within one-dimensional graphitized carbon/carbon nanotubes supported on micro-scale Mo2N rod(Mo2N@CoFe@C/CNT),constructing a special multi-dimension hierarchical MA material.Ligand exchange reaction is found to determine the formation of hierarchical magnetic-dielectric composite,which is assembled by dielectric Mo2N as core and spatially dispersed CoFe nanoparticles within C/CNTs as shell.Mo2N@CoFe@C/CNT composites exhibit superior MA performance with maximum reflection loss of−53.5 dB at 2 mm thickness and show a broad effective absorption bandwidth of 5.0 GHz.The Mo2N@CoFe@C/CNT composites hold the following advantages:(1)hierarchical core–shell structure offers plentiful of heterojunction interfaces and triggers interfacial polarization,(2)unique electronic migration/hop paths in the graphitized C/CNTs and Mo2N rod facilitate conductive loss,(3)highly dispersed magnetic CoFe nanoparticles within“tubes on rods”matrix build multi-scale magnetic coupling network and reinforce magnetic response capability,confirmed by the off-axis electron holography.     

Glass crystallization making red phosphor for high-power warm white lighting

Rapid development of solid-state lighting technology requires new materials with highly efficient and stable luminescence, and especially relies on blue light p...     

Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response

With the advancement of science and technology, humans are chronically exposed to ionizing radiation. It is crucial to look for efficient and low-toxic anti-radiation agents. Through preliminary screening, we found that Acanthopanax senticosus polysaccharide (ASPS) played a major role in regulating immune damage caused by radiation. The objective of this study was to apply the Caenorhabditis elegans—P. aeruginosa (PA14) infection model to illuminate the mechanism of ASPS increasing the pathogen resistance of radiation-damaged nematodes. Results indicated that ASPS (1 mg/mL) significantly enhanced the pathogen resistance of radiation-damaged nematodes by directly elevating the immune response of nematodes rather than by affecting the bacterial activity. Through further research on the p38 MAPK signaling pathway and related mutants, we found that ASPS functioned by the p38 MAPK pathway in the intestine, and SKN-1, ATF-7 as the downstream targets of PMK-1 participated the regulation of ASPS. In addition, ASPS markedly alleviated the stress status of damaged nematodes by regulating oxidative stress. Collectively, our findings suggest that ASPS enhances the pathogen resistance of radiation-damaged nematodes through the intestinal p38MAPK-SKN-1/ATF-7 pathway and stress response.     

影响挠性印制板插入损耗的几种因素

文章采用三层板叠构对高频通信用挠性印制板(FPCB)的插损进行测试对比,从制造FPCB的材料种类、材料厚度、胶层厚度、仿真设计、信号线过孔类型、盲孔质量,以及信号线阻抗值大小等多个因素总结出对最高频率到20GHz信号插损的影响.     

Effectiveness and petroleum geological significance of tectonic fractures in the ultra-deep zone of the Kuqa foreland thrust belt:a case study of the Cretaceous Bashijiqike Formation in the Keshen gas field

The buried depth of the gas-producing reservoir in the Kuqa foreland thrust belt of the Tarim Basin exceeds 6000 m.The average matrix porosity of the reservoir ...     

On the robustness of median sampling in noisy evolutionary optimization

Evolutionary algorithms (EAs) are a sort of nature-inspired metaheuristics,which have wide applications in various practical optimization problems.In these prob...     

冷轧带钢表面缺陷在线监测系统

介绍一套目前已在实验室中开发成功的冷轧带钢表面缺陷在线监测系统,该系统用于在线检测和识别冷轧带钢的表面缺陷.系统采用多个面阵CCD摄像头同步采集带钢表面的图像,并通过并行计算系统对图像进行分析和处理,以得到钢板表面的缺陷情况.系统在软件流程上进行了特殊的设计,以保证实时数据处理功能.经试验,系统对\     

Antibacterial Properties of an Austenitic Antibacterial Stainless Steel and Its Security for Human Body

An austenitic antibacterial stainless steel is reported in this paper. The very fine and dispersive ε-Cu precipitations in the matrix of the antibacterial steel after the antibacterial treatment endow the steel with antibacterial function. The antibacterial function is strong, long-term and broad-spectrum, and can be maintained even after repeated wear and long time dipping in water. The steel is safe for human body and could be used widely in daily application.     

基于熵相关系数的关联性自动判别方法——COCA

数据库自管理、自调优中查询计划的自动优化是目前的关注热点。为保证优化器估值精度,用统计学方法,给出了一种基于熵相关系数的对字段关联性的自动判别的新算法——COCA。该算法有下列特点：（1）限制少,没有卡方检验的频数限制,卡方检验只有在列联表中至少有80%的格子频数大于5的情况下才可信; （2）结果多,卡方检验（CORDS）只判断字段之间是否有关联,新方法可计算字段之间双向的关联程度。实验表明, 新方法更坚固,产生更多的统计信息,可以支持后面更高效、准确地建立直方图。