Peptidyl Virus-Like Nanovesicles as Reconfigurable “Trojan Horse” for Targeted siRNA Delivery and Synergistic Inhibition of Cancer Cells

The self-assembly of peptidyl virus-like nanovesicles (pVLNs) composed of highly ordered peptide bilayer membranes that encapsulate the small interfering RNA (siRNA) is reported. The targeting and enzyme-responsive sequences on the bilayer's surface allow the pVLNs to enter cancer cells with high efficiency and control the release of genetic drugs in response to the subcellular environment. By transforming its structure in response to the highly expressed enzyme matrix metalloproteinase 7 (MMP-7) in cancer cells, it helps the siRNA escape from the lysosomes, resulting in a final silencing efficiency of 92%. Moreover, the pVLNs can serve as reconfigurable “Trojan horse” by transforming into membranes triggered by the MMP-7 and disrupting the cytoplasmic structure, thereby achieving synergistic anticancer effects and 96% cancer cell mortality with little damage to normal cells. The pVLNs benefit from their biocompatibility, targeting, and enzyme responsiveness, making them a promising platform for gene therapy and anticancer therapy.     

基于MSP430F149的便携式超声波测距仪设计

根据超声波测距原理,设计了一种基于MSP430F149的便携式超声波测距仪;详细介绍了该测距仪硬件电路的设计,并给出了该测距仪软件主程序流程。测试结果表明,该测距仪运行稳定、性能可靠,测量精度可达2 mm。     

基于Internet的物联网系统中设备互联和实时在线技术

针对物联网系统中信息交互的实时性和系统自治特性,提出一种基于Internet和嵌入式设备构建物联网的技术;通过基于客户/服务器的体系结构和面向连接的设备实时在线技术实现信息交互的实时性,进一步通过一种服务器地址自动迁移技术实现基于Inter-net的嵌入式设备物联网的系统自治特性;通过多台嵌入式设备组网进行实际测试验证,系统满足良好的扩展性和设备即插即用特性,设备间数据通信相应时间低于1s,具有良好的实时性,可广泛应用于嵌入式设备的互联互通。     

一种多功能网络监控与防御平台设计与实现

本文提出了一种多功能网络监控与防御系统。文中根据网络自身的结构,从骨干层、汇聚层、接入层三个层次分析,采用三层设计模式,它们相互独立又相互协作,共同构成高性能、多层次、多功能综合解决方案。形成深度防御体系,最大限度地保护企业和组织的网络安全。     

Mesh Decomposition with Cross‐Boundary Brushes

We present a new intuitive UI, which we call cross‐boundary brushes, for interactive mesh decomposition. The user roughly draws one or more strokes across a desired cut and our system automatically returns a best cut running through all the strokes. By the different natures of part components (i.e., semantic parts) and patch components (i.e., flatter surface patches) in general models, we design two corresponding brushes: part‐brush and patch‐brush. These two types of brushes share a common user interface, enabling easy switch between them. The part‐brush executes a cut along an isoline of a harmonic field driven by the user‐specified strokes. We show that the inherent smoothness of the harmonic field together with a carefully designed isoline selection scheme lead to segmentation results that are insensitive to noise, pose, tessellation and variation in user's strokes. Our patch‐brush uses a novel facet‐based surface metric that alleviates sensitivity to noise and fine details common in region‐growing algorithms. Extensive experimental results demonstrate that our cutting tools can produce user‐desired segmentations for a wide variety of models even with single strokes. We also show that our tools outperform the state‐of‐art interactive segmentation tools in terms of ease of use and segmentation quality.     

An axiom system for sequence-based specification

This paper establishes an axiomatic foundation and a representation theorem for the rigorous, constructive process, called sequence-based specification, of deriving precise specifications from ordinary (informal) statements of functional requirements. The representation theorem targets a special class of Mealy state machines, and algorithms are presented for converting from the set of sequences that define the specification to the equivalent Mealy machine, and vice versa. Since its inception, sequence-based specification has been effectively used in a variety of real applications, with gains reported in quality and productivity. This paper establishes the mathematical foundation independently of the process itself.     

Analytical modelling of networks in multicomputer systems under bursty and batch arrival traffic

The hypercube and torus are two important message-passing network architectures of high-performance multicomputers. Analytical models of multicomputer networks under the non-bursty Poisson traffic have been widely reported. Motivated by the convincing evidence of bursty and batch arrival nature of traffic generated by many real-world parallel applications in high-performance computing environments, we develop a new and concise analytical model in this paper for hypercube and torus networks in the presence of batch message arrivals modelled by the compound Poisson process with geometrically distributed batch sizes. The average degree of virtual channel multiplexing is derived by employing a Markov chain which can capture the batch arrival nature. An attractive advantage of the model is its constant computation complexity independent of the network size. The accuracy of the analytical performance results is validated against those obtained from simulation experiments of an actual system.     

一种基于可信度矩阵的多传感器目标识别方法

为了解决多传感器目标识别中不同等级信息源数据的融合问题,在研究DSmT证据理论的基础上,引入证据可信度矩阵.依据可信度矩阵对证据进行转化,使之可以用传统的方法进行证据融合.将这种方法应用到等级不同的多传感器目标识别中,可以解决传统证据理论只能进行相同等级传感器目标识别的难题.仿真实验表明,该方法提高了目标识别的准确性和有效性.