Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro

Negatively charged fluorescent carbon dots (CDs, E_m=608 nm) were hydrothermally prepared from thiophene phenylpropionic acid polymers and then successfully loaded with the positively charged anticancer cargo coptisine, which suffers from poor bioavailability. The formed CD-coptisine complexes were thoroughly characterized by particle size, morphology, drug loading efficiency, drug release, cellular uptake and cellular toxicity in vitro and antitumor activities in vivo. In this nano-carrier system, red emissive CDs possess multiple advantages as follows: 1) high drug loading efficiency (>96 %); 2) sustained drug release; 3) enhanced drug efficacy towards cancer cells; 4) EPR effect; 5) drug release tracing with near-infrared imaging. These properties indicated that red emissive CDs prepared from polymers could be used as a novel drug delivery system with integrated therapeutic and imaging functions in cancer therapy, which are expected to have great potential in future clinical applications.     

High-performance Multicrystalline Silicon Ingots Assisted by Recycled Multicrystalline Silicon Block Tailing as Seeds

Silicon - Nowadays, casted multicrystalline silicon is the most important material in photovoltaic industry. In order to reduce the cost of silicon ingots, the recycle of silicon ingot tailings is...     

235/75R15 FRD78非对称花纹雪地轮胎的设计

介绍235/75R15 FRD78非对称花纹雪地轮胎的设计。结构设计:外直径722 mm,断面宽241 mm,行驶面宽度179 mm,行驶面弧度高7.5 mm,胎圈着合直径375 mm,胎圈着合宽度197.8 mm,断面水平轴位置(H₁/H₂)0.97729,胎面采用4条纵向花纹沟槽设计,花纹深度9 mm,花纹饱和度69.18%,花纹周节数36。施工设计:胎面采用分层挤出,胎侧采用双复合设计,冠带层采用锦纶66帘线,1^#和2^#带束层使用3×0.30HT钢丝帘线,胎体采用高模量低收缩聚酯帘线,采用一次法成型机成型、液压硫化机和氮气硫化工艺硫化。成品性能试验结果表明,轮胎的充气外缘尺寸、强度性能、耐久性能和高速性能均达到相应设计和企业标准要求。     

电缆中间接头受潮时电场分布研究

通过ANSYS软件建立10 kV电缆冷缩式中间接头的三维模型,并仿真计算静电场,主要分析不同受潮情况下电场分量的分布情况.结果表明:接头绝缘材料受潮时,复合界面上的电场增大;接头浸水时间越长,电场畸变越严重;主绝缘内侧受潮时水膜对周围的电场分布几乎没有影响,水膜处电场增大,但场强依然保持在极低的水平.     

陕北±800 kV换流站高填方湿陷性黄土地基处理方案研究

陕北±800 kV换流站用地为原循环工业经济园区挖黄土梁卯、填深沟给出的一块台阶式场地,场地覆盖一层厚度0~50 m的素填土,密实度差异较大,土质极不均匀,填土完成约5年半时间,是一种欠固结土,在其自身重度和大气降水的入渗作用下有自行密实的特点,影响位于填方区建(构)筑物地基的承载力和稳定性。基于该工程特殊的岩土地质情况,除挖方区采用天然地基外,从处理填方区大面积欠固结土和消除部分地基土湿陷性、提高地基土承载力、减小场地沉降变形的角度,对不同地基处理及桩基方案进行技术经济综合比选,提出适合本工程的经济合理的地基处理方案。     

濒海软弱地基场地翻车机室地下部分结构设计与施工方案选型

结合某工程濒海软弱地基场地翻车机室,对其地下部分的常规结构设计方案与沉井结构设计方案、以及相应的各种施工方案进行分析比较,并对其技术经济指标进行对比.分析结果表明,对于此类工程地质条件的场地,翻车机室地下部分采用沉井结构设计和施工方案是较为适宜的.     

基于冷凝热的除霜技术在多联机中的实验研究

冬季制热场景下,空气源产品存在因室外换热器除霜而导致室内定期停止制热现象,引起室内温度降低,用户体验差,因此提高除霜运行时室内用户的舒适体性验,成为空气源热泵面临的重要课题.通过对家用多联机系统进行重新设计:将室外换热器划分为两个部分,通过控制制冷剂的饱和温度,利用制冷剂冷凝热,实现对室外换热器进行有效的交替除霜.实验证明:1.在除霜饱和温度Td为2℃～8℃时可用最少的制冷剂流量实现有效除霜;2.在室外2℃条件下,冷凝热除霜运行中的平均制热能力为额定能力的75％.     

粗粒料三轴试验橡皮膜嵌入量数值模拟

在粗粒料三轴试验中,橡皮膜嵌入量可造成显著的体积变形量测误差。本文针对颗粒材料的接触特点,利用Nagata Patch方法重建颗粒表面,基于重建曲面进行接触状态的判断和接触几何信息的计算,开发了高效的颗粒接触算法。该法采用dual mortar有限元方法处理颗粒与橡皮膜间的接触模拟,针对橡皮膜变形较大的特点,采用更新坐标的大变形计算格式,并根据重建的颗粒表面对颗粒-橡皮膜的距离进行几何修正,实现了颗粒-橡皮膜接触的精细化模拟,可较好地模拟计算“柔性”橡皮膜嵌入颗粒孔隙的过程。进行了Kramer钢球试验以及粗颗粒料和标准粗砂三轴试验橡皮膜嵌入过程的模拟计算,计算结果符合一般规律,与相应的试验结果吻合较好,验证了本文方法对于粗粒料膜嵌入问题的适用性。     

Experimental research on steady-state operation characteristics of gas–solid flow in a 15.5 m dual circulating fluidized bed system

Gas-solid hydrodynamic steady-state operation is the operating basis in a chemical looping dual-reactor system. This study reported the experimental results on the steady-state operation characteristics of gas–solid flow in a 15.5 m high dual circulating fluidized bed(CFB) cold test system. The effects of superficial gas velocity, static bed material height and solid returning modes on the steady-state operation characteristics between the two CFBs were investigated. Results suggest that the solid distributions in the dual CFB test system was mainly determined by the superficial gas velocity and larger solid inventory may help to improve the solid distributions. Besides, cross-returning mode coupled with self-returning is good for steady-state running in the dual-reactor test system.     

超导故障限流器抑制短路电流直流分量的仿真分析

短路电流中的周期分量和直流分量对系统短路容量都有贡献,而后者在工程应用中没有引起足够的重视.目前我国宁夏、上海、广州等电网普遍面临短路电流直流分量超标,系统保护装置难以可靠清除故障的状况,严重威胁电力系统的安全可靠性.基于此,本文提出使用超导故障限流器在限制短路电流幅值的同时,抑制短路电流直流分量的方法,缓解断路器的开断负担.目前超导限流器对短路电流直流分量的抑制效果及在高直流分量系统超导限流器的设计方法尚不清楚.因此,搭建了超导故障限流器模型,以330 kV系统为例,研究了不同直流分量时间常数下超导限流器阻值与直流分量的关系,提出了超导故障限流器失超阻值的优化设计方法.结果表明在不同的短路故障条件下,超导限流器对直流分量的抑制效果均非常明显,能有效提高系统的可靠性.