Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts

We examined the effects of different cytokine combinations and culture conditions on the expansion and modulation of cell surface antigens of CD34+ derived dendritic cells (DCs), the most efficient antigen-presenting cells capable of stimulating resting T cells in the primary immune response. Cells with a dendritic morphology and expressing HLA-DR, CD1a, S100 and CD83 were maximally expanded under serum-free conditions with the addition of SCF, GM-CSF, TNF-alpha, TGF-beta and Flt-3 ligand (fold increase of CD1a+ cells = 102 +/- 32 after 2 weeks of culture). CD34+ cells were also grown under continuous flow conditions in an artificial capillary system: after 14d of culture, the expansion in the total cell number was lower than that of the static cultures (3.3 +/- 2 v 18.9 +/- 4) but the percentage of CD1a+/CD83+/ CD80+ cells was considerably higher, whereas the CD14+ cells were significantly reduced (8.9 +/- 2 v 26 +/- 13). In continuous perfusion cultures, low levels of DC precursors and of LTC-IC were still present up to day 14. The DCs generated under flow conditions stimulated the mixed leucocyte reaction (MLR) more than the cells grown in static cultures. By electron microscopy, cells grown in the continuous flow system showed an increased number of large cells with numerous dendritic processes and abundant multilamellar complexes. The cells expanded under these conditions were sorted on the basis of their light-scatter properties into two fractions: one containing a predominance of CD1a+/S100+/ CD8 3+/CD80+/CD14- 'large cells' with great internal complexity (mature DCs); the second including 'small cells' either CD33+/CD14+, CD33+/CD15+ or CD33+/CD13-/CD14. The DCs generated and selected with this method are therefore particularly well suited for immunotherapeutic protocols.     

Effect of hydrogen loading on temperature/electric-field poling ofSiO2-based thin films on Si

Waveguide stacks of GeSiO₂-based glass deposited on Si exhibit a permanent second-order nonlinearity following temperature electric-field poling. High temperature hydrogen loading increases the second harmonic signal under certain conditions     

网络对抗训练混合虚拟化平台设计研究

讨论了虚拟化技术实现原理及其在网络对抗教学中的应用上,分析了各类虚拟化技术的优缺点和构建网络对抗训练环境存在的问题。提出了一种混合虚拟化平台设计,该平台利用Libvirt虚拟化的应用程序编程接口（API）调用两种虚拟化技术同时运行在同一物理主机上。并详细叙述了混合虚拟化平台的实现过程和方法,并在多个虚拟机内同时运行测试基准,分析其可扩展性。多种虚拟化技术在同一物理机上的混合,实现了复杂实验环境的创建,对构建大规模的网络实验平台具有一定的参考价值。     

Negative effects of sufficiently small initial weights on back-propagation neural networks

In the training of feedforward neural networks,it is usually suggested that the initial weights should be small in magnitude in order to prevent premature saturation.The aim of this paper is to point out the other side of the story:In some cases,the gradient of the error functions is zero not only for infinitely large weights but also for zero weights.Slow convergence in the beginning of the training procedure is often the result of sufficiently small initial weights.Therefore,we suggest that,in these cases,the initial values of the weights should be neither too large,nor too small.For instance,a typical range of choices of the initial weights might be something like(0.4,0.1) ∪(0.1,0.4),rather than(0.1,0.1) as suggested by the usual strategy.Our theory that medium size weights should be used has also been extended to a few commonly used transfer functions and error functions.Numerical experiments are carried out to support our theoretical findings.     

新的e修正鲁棒自适应控制方法在航空发动机上的应用

针对航空发动机模型的结构和参数的不确定性,提出一种基于非李亚普诺夫方程(NQLF)的e修正鲁棒模型参考自适应控制法。该方法无需知道发动机精确数学模型,抗干扰能力强,在输出误差信号的作用下具有比普通方法更快的收敛性,振荡性能够得到很好的控制。从仿真结果可见控制器能使系统比较好地跟踪参考模型的输出,对发动机模型参数和结构的变化有一定的适应能力,鲁棒性较好。     

全面建设小康社会进程中黄河流域水资源利用效率时空演变分析

提升水资源利用效率,减轻水资源短缺对经济社会发展产生的约束,是实现水资源与经济社会和谐发展的有力支撑。尝试将DEA视窗分析方法应用于水资源利用效率研究,结合超效率DEA模型,探究黄河流域九省区在全面小康社会建设进程中水资源利用效率时空演变特征,在此基础上,通过Malmquist指数分解效率变动的内在原因,并引用空间匹配度计算方法,研究水资源利用效率与全面小康相对水平匹配程度。研究发现:九省区2012—2018年水资源利用效率总体呈增加趋势,水资源利用水平具有显著空间差异性;九省区水资源利用效率的提升主要得益于技术进步TC,制约水资源利用效率提升的主要因素是综合技术效率EC;水资源利用效率与全面小康相对水平的匹配程度呈现出较强的地区差异,部分省区两者动态协同性较差,其中,宁夏需要同时提升水资源利用水平和经济社会发展水平,陕西需要提升水资源利用水平,内蒙古需要提升经济社会发展水平。     

基于IFMOP的玉环市区域水资源配置

引入无概率分布的区间数表示不确定性影响范围,选取经济效益、供需水效率和COD排放量分别构建经济目标、社会目标和环境目标优化函数,构建了玉环市不确定性模糊多目标规划(IFMOP)水资源配置模型,并计算了不确定性解集。结果表明:IFMOP配置计算成果可实现玉环市区域水量水质协调高效利用和社会-经济-生态系统均衡发展;在75%来水保证率下各行业配置总水量不确定性范围为14 375万~15 154万m³。IFMOP水资源配置模型在信息不充分的条件下能够全面使用各类数据信息进行水资源配置,更好地满足水资源在各行业配置过程中的动态管理需求。     

水管单位安全生产标准化创建动态评价与关键因素分析

近年来我国经济快速发展,水利基础设施发挥了巨大的作用,尤其是安全生产标准化的推行,促进了水利工程平稳投产及运营.水管单位安全生产标准化评审涉及体系建设、教育培训、现场运管、应急管理等方面,考核事项众多,所以明确创建关键因素、动态评价创建成效是标准化创建的重要任务.基于层次分析法建立标准化评价指标体系,分析创建各阶段中具有主导作用的关键因素,以江苏水管单位的标准化创建实例,探讨了动态评价方法的应用.     

密云水库第一溢洪道水工大体积商品混凝土温控计算方法与措施研究

密云水库第一溢洪道是洪水期间保证密云水库安全的重要设施,溢洪道闸室段对强度和裂缝限制要求较高.利用经验公式、数值模型2种方法初步计算大体积商品混凝土的温度过程,为现场采取温控措施提供参考,进行浇筑施工并实时测温,然后以现场浇筑情况作为边界条件重新计算,与现场实测结果对比验证;用数值模型进一步分析不同温控措施的敏感性.定量分析结果表明,经验公式计算的外部温度过程比实测偏低,数值模型计算结果与实测相近,建议大型水利工程温度计算尽量采用数值模拟;混凝土最大温升受浇筑温度、冷却水管布置密度的影响较大,冷却结束时的温度受冷却水管布置密度、通水时长、模板导热系数影响较大.裂缝实测结果显示工程制定的浇筑方案合理可行,可以为类似工程提供借鉴.