Lipophilic NO-Driven Nanomotors as Drug Balloon Coating for the Treatment of Atherosclerosis

Drug-coated balloons (DCB) intervention is an important approach for the treatment of atherosclerosis (AS). However, this therapeutic approach has the drawbacks of poor drug retention and penetration at the lesion site. Here, a lipophilic drug-loaded nanomotor as a modified balloon coating for the treatment of AS is reported. First, a lipophilic nanomotor PMA-TPP/PTX loaded with drug PTX and lipophilic triphenylphosphine (TPP) compounds is synthesized. The PMA-TPP/PTX nanomotors use nitric oxide (NO) as the driving force, which is produced from the reaction between arginine on the motor substrate and excess reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) in the AS microenvironment. The final in vitro and in vivo experimental results confirm that the introduction of the lipophilic drug-loaded nanomotor technology can greatly enhance the drug retention and permeability in atherosclerotic lesions. In particular, NO can also play an anti-AS role in improving endothelial cell function and reducing oxidative stress. The chemotherapeutic drug PTX loaded onto the nanomotors can inhibit cell division and proliferation, thereby exerting the effect of inhibiting vascular intimal hyperplasia, which is helpful for the multiple therapies of AS. Using nanomotor technology to solve cardiovascular diseases may be a promising research direction.     

谈土工布加筋柔性挡墙的工程监理

土工布加筋柔性挡墙具有抗震性好 ,造价低 ,适用于软土地基的特点。本文详细阐述了监理工作在某防洪排涝工程建设过程中应如何从投资、进度、质量 (尤其是原材料质量和施工质量 )等方面进行合理控制 ,以确保工程保质保量按时交付使用     

Facile synthesis of thin coating C/ZnO composites with strong electromagnetic wave absorption

C/ZnO composites with increased electromagnetic (EM) wave absorbing features have been synthesized through a simple one-pot hydrothermal process and subsequent high temperature carbonization under the protection of argon. The results depict that the maximum absorption of C/ZnO composites synthesized with the optimal molar ratio of zinc acetate to glucose is ?50.43?dB at 15.77?GHz. The 1.16-mm-thick coating shows a wide effective absorption bandwidth (3.52?GHz) of EM wave (RL≤?10?dB). The thin coating thickness of the C/ZnO composites is desirable for decreasing the absorber weight in EM wave absorption. And there are no other reagents used throughout the synthesis process except for the green glucose and zinc acetate. Thus, C/ZnO composites would be highly promising lightweight EM wave absorbing materials.     

赣抚平原灌区末级渠系管理体制改革探讨

如何发挥灌区效益,提高水资源利用效率,一直是灌区管理部门研究的核心问题。当前水量浪费大、管理不规范的在灌区的末级渠系。灌区末级渠系是指灌区斗渠及其以下田间灌溉渠系,是灌区最基础的渠系网络．承担着干支渠道水量向田间输送的功能．是发挥灌溉效益、联结灌区千家万户的桥梁和纽带,在农业生产灌溉中起着十分重要的作用。针对江西赣抚平原灌区的有效探索,进行末级渠系管理体制改革的探讨。     

基于SSL1623的LED驱动器设计

论文介绍了基于SSL1623的LED驱动器设计过程,分别对芯片控制电路、反激变压器和反馈环路进行了讨论,计算了驱动器的参数,最后给出了测试结果以及波形,并进行了分析。     

上海地区地下工程专用混凝土的应用研究

耐久性混凝土的胶凝材料用量少,抗裂性高减少了后期修补费用,既满足耐久性要求,又兼顾绿色化。随着上海轨道交通和隧道工程的迅速发展,地下工程混凝土对耐久性的要求越来越高。本文简述了聚羧酸类外加剂配制的耐久性混凝土在上海地区地下工程的应用情况、存在的问题及解决方法。     

Coherent energy projection of modulated signals from a sparse array

In this article, coherent energy projection is generalized to modulated signals, enabling the precise delivery of energy to a specific target area. The system and mathematical model are established to characterize the far‐field energy interference from a randomized sparse transmitting array. By using the method of transmitting delay pre‐compensation and spatial coherent combination, the coherent energy of the modulated signals increases significantly after demodulation at the receiving end. The coherent energy scape is presented to describe the spatial distribution of projected energy in the target area, rather than the commonly used performance metric of front‐end energy analysis. Then the simulations set out to examine the spatial grating lobes and potential for expanding the focal spot using multi‐foci accumulation. We also employ the particle swarm optimization to find the optimum distribution of foci to match the focal spot with the desired target area and energy level. Analysis and numerical results are provided to demonstrate the correctness of the theoretical results and effectiveness of the proposed coherent energy projection method.     

Cost Optimization of Partial Computation Offloading and Pricing in Vehicular Networks

Journal of Signal Processing Systems - For vehicles with limited computation resources offloading their computational tasks to a mobile edge computing (MEC) server has been studied in the past as...