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991.
黑果腺肋花楸是目前含有花青素、多酚含量最高的植物,其活性物质具有多种保健功能。然而,其中的花色苷稳定性差,利用率低,在各行业的应用受到限制。本研究采用壳聚糖与聚谷氨酸经离子凝胶法对黑果腺肋花楸花色苷进行包埋,来提高其稳定性。通过单因素实验确定3个影响显著的因素。以花色苷纳米微胶囊包埋率为指标,响应面优化后的最佳条件为:花色苷添加量36 mg、壳聚糖质量浓度1.3 mg/mL、搅拌时间60 min、壳聚糖∶聚谷氨酸质量比2∶1、pH 4.5。在此条件下所得纳米微胶囊包埋率为59.54%,粒径317.5 nm,Zeta电位36.7 mV。通过扫描电镜观察,黑果腺肋花楸花色苷纳米微胶囊外表光滑,呈规则的球状,表明其具有良好的结构和稳定性,有利于其在食品工业中的应用。 相似文献
992.
Xuejing Zhu Dan Gao Vittorio Albertazzi Jianyong Zhong Li-Jun Ma Liping Du Yu Shyr Valentina Kon Hai-Chun Yang Agnes B. Fogo 《International journal of molecular sciences》2022,23(11)
We previously found that short-term treatment (week 8 to 12 after injury) with high-dose angiotensin receptor blocker (ARB) induced the regression of existing glomerulosclerosis in 5/6 nephrectomy rats. We therefore assessed the effects of long-term intervention with ARB vs. nonspecific antihypertensives in this study. Adult rats underwent 5/6 nephrectomy and renal biopsy 8 weeks later. The rats were then divided into three groups with equivalent renal function and glomerular sclerosis and treated with high-dose losartan (ARB), nonspecific antihypertensive triple-therapy (TRX), or left untreated (Control) until week 30. We found that blood pressure, serum creatinine levels, and glomerulosclerosis were lower at sacrifice in ARB and TRX vs. Control. Only ARB reduced proteinuria and maintained the density of WT-1-positive podocytes. Glomerular tufts showed more double-positive cells for CD44, a marker of activated parietal epithelial cells, and synaptopodin after ARB vs. TRX or Control. ARB treatment reduced aldosterone levels. ARB-treated rats had significantly improved survival when compared with TRX or Control. We conclude that both long-term ARB and triple-therapy ameliorate progression, but do not sustain the regression of glomerulosclerosis. ARB resulted in the superior preservation of podocyte integrity and decreased proteinuria and aldosterone, linked to increased survival in the uremic environment. 相似文献
993.
994.
在DLG-1型催化剂上进行了液化石油气(LPG)的低温芳构化反应研究,考察了反应温度、氢分压及进料液体体积空速对LPG制取高辛烷值汽油反应性能的影响,分析了反应时间与催化剂积炭量的关系,并对再生催化剂的反应活性进行了评价.结果表明,在反应温度为400~420℃,氢分压为1.9~2.0 MPa,进料液体体积空速为0.9~1.4 h-1的条件下,反应产物的收率达到99.39%,汽油的研究法辛烷值为98.7.当催化剂上的积炭量大于18.31%时,催化剂会因结焦而暂时失活,但再生后其活性及稳定性恢复较好.再生催化剂在600 h的稳定运行实验中,C4烯烃的转化率均在99.5%以上. 相似文献
995.
Yongjie Liu Dan Li Shengquan Zhang Liping Zhang Jie Gong Yanhong Li Jiamin Chen Fengting Zhang Xiangzheng Liao Zhaobo Chen Yongbo Wang Binshuang Pang Jinxiu Ma Xianchao Chen Jiangang Gao Changping Zhao Shiqing Gao 《International journal of molecular sciences》2022,23(15)
Temperature-sensitive genic male sterile (TGMS) line Beijing Sterility 366 (BS366) has been utilized in hybrid breeding for a long time, but the molecular mechanism underlying male sterility remains unclear. Expression arrays, small RNA, and degradome sequencing were used in this study to explore the potential role of miRNA in the cold-induced male sterility of BS366. Microspore observation showed defective cell plates in dyads and tetrads and shrunken microspores at the vacuolated stage. Differential regulation of Golgi vesicle transport, phragmoplast formation, sporopollenin biosynthesis, pollen exine formation, and lipid metabolism were observed between cold and control conditions. Pollen development was significantly represented in the 352 antagonistic miRNA-target pairs in the integrated analysis of miRNA and mRNA profiles. The specific cleavage of ARF17 and TIR1 by miR160 and miR393 were found in the cold-treated BS366 degradome, respectively. Thus, the cold-mediated miRNAs impaired cell plate formation through repression of Golgi vesicle transport and phragmoplast formation. The repressed expression of ARF17 and TIR1 impaired pollen exine formation. The results of this study will contribute to our understanding of the roles of miRNAs in male sterility in wheat. 相似文献
996.
997.
Rongrong Luo Lei Chen Xingxing Song Xin Zhang Wenhao Xu Dongyang Han Jianyu Zuo Wen Hu Yan Shi Yajie Cao Runwen Ma Chengcheng Liu Changlin Xu Zixin Li Xun Li 《International journal of molecular sciences》2022,23(15)
Gonadotropin-inhibitory hormone (GnIH) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis and reproduction. However, whether GnIH is a molecular signal link of metabolism and the reproductive system, and thus, regulates reproductive activity as a function of the energy state, is still unknown. In the present study, we investigated the involvement of GnIH in glycolipid metabolism and reproduction in vivo, and in the coupling between these two processes in the testis level. Our results showed that chronic intraperitoneal injection of GnIH into male mice not only increased food intake and altered meal microstructure but also significantly elevated body mass due to the increased mass of liver and epididymal white adipose tissue (eWAT), despite the loss of testicular weight. Furthermore, chronic intraperitoneal administration of GnIH to male mice resulted in obesity-related glycolipid metabolic derangements, showing hyperlipidemia, hyperglycemia, glucose intolerance, and insulin resistance through changes in the expression of glucose and lipid metabolism-related genes in the pancreas and eWAT, respectively. Interestingly, the expression of GnIH and GPR147 was markedly increased in the testis of mice under conditions of energy imbalance, such as fasting, acute hypoglycemia, and hyperglycemia. In addition, chronic GnIH injection markedly inhibited glucose and lipid metabolism of mice testis while significantly decreasing testosterone synthesis and sperm quality, inducing hypogonadism. These observations indicated that orexigenic GnIH triggers hyperphagia-induced obesity-related metabolic derangements and hypogonadism in male mice, suggesting that GnIH is an emerging candidate for coupling metabolism and fertility by involvement in obesity and metabolic disorder-induced reproductive dysfunction of the testes. 相似文献
998.
Two new different metal-organic frameworks (MOFs)[Ba(L1)(H2O)2]n·nH2O (MOF 1) and[Ba(L2)(-H2O)2]n·0.5nDMF·0.5nH2O (MOF 2) were yielded by the assembly of oxygen... 相似文献
999.
Po Hu Zhi-Guo Ma Kai Zhao Guo-Qiang Zhang De-Qing Fang Bao-Ren Wei Chang-Bo Fu Yu-Gang Ma 《核技术(英文版)》2021,32(6):84-92
With the development of laser technologies,nuclear reactions can happen in high-temperature plasma environments induced by lasers and have attracted a lot of at... 相似文献
1000.
The result of the eddy current inspection for the thimble tube of a nuclear reactor neutron flux measurement system is the reference for the nuclear power plant to take maintenance actions. Based on the currently-used eddy current inspection method, the effect of the parameter variation of the tube defect on the depth quantification is analyzed. The results show that when the angle of the defect circumferential is less than 210°, it has a greater effect on the eddy current measurement depth quantification and when the defect length is less than 20mm, the effect of the defect depth quantification is obviously. The measurement depth in the eddy current of the crescent-type defect is smaller than the design depth. When the circumferential position of two defects is constant, the overlapped defect has no effect on the measurement, but the overlapped defect will have serious influence for the measurement result if the circumferential position of the two defects changes. 相似文献