Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells

Tramadol hydrochloride is a centrally acting synthetic analgesic in widespread clinical use. Despite different degrees of opioid-like characteristics in preclinical tests, it is characterized by lack of full naloxone reversibility or naloxone-precipitated withdrawal in humans. To investigate this apparent discrepancy, the present study measured the affinity of tramadol (and its enantiomers) and an active O-desmethyl metabolite (M1) (and its enantiomers) to cloned human opioid receptors of the mu, delta and kappa type stably expressed in HN9.10 neuroblastoma cells. At mu sites, the Ki values for tramadol, its (+) and (-) enantiomers, M1, and its (+) and (-) enantiomers were 17000, 15700, 28800, 3190, 153 and 9680 nM, respectively, compared to 7.1 nM for morphine. These results are consistent with the suggestion of a non-opioid contribution to the clinical profile of tramadol.     

具有再生反馈雷达的角跟踪性能闭环测试

本文论述了用雷达跟踪目标最大角速度和角加速表征具有再生反馈雷达角跟踪性能的合理性,并论述了用单片机测试雷达跟踪目标最大角速度和最大角加速的方法。     

A method of calculating the compression deformation modulus of sandy and gravelly soils

A method based on use of Hardin's homogeneous model is proposed for calculation of the deformation modulus of noncohesive soils. Completely satisfactory correspondence between computed and experimental values of the deformation modulus of sands is demonstrated. Translated from Osnovaniya, Fundamenty i Mekhanika Gruntov, No. 4, pp. 2–5, July–August, 1994.     

碱性氰化物防渗碳光亮镀铜工艺的研究

本文介绍了一种高效率，高韧性，防渗碳底铜工艺，可以大辐度提高镀层的沉积速度，降低铜层孔隙率，提高产品合格率，具有显著的经济效益和社会效益。     

输入——输出迭代算法中松弛因子的确定

本文利用变分的手段提示了输入—输出迭代算法中松弛因子的取值规律。     

Application of artificial neural networks in voltage stabilityassessment

Voltage stability problems have been one of the major concerns for electric utilities as a result of system heavy loading. This paper reports on an investigation on the application of ANNs in voltage stability assessment. A multilayer feedforward artificial neural network (ANN) with error backpropagation learning is proposed for calculation of voltage stability margins (VSM). Based on the energy method, a direct mapping relation between power system loading conditions and the VSMs is set up via the ANN. A systematic method for selecting the ANN's input variables was developed using sensitivity analysis. The effects of ANN's training pattern sensitivity problems were also studied by dividing system operating conditions into several loading levels based on sensitivity analysis. Extensive testing of the proposed ANN-based approach indicate its viability for power system voltage stability assessment. Simulation results on five test systems are reported in the paper     

中温低氰液体碳氮共渗及其应用效果

通过金相、硬度、耐磨性等测试分析表明，在“６０３”液体渗碳基础上研制出的新型中温低氰液体碳氮共渗剂对薄片件进行薄层碳氮共渗．能完全满足技术要求，并且取得了良好经济和社会效益．     

Characterization of expression of phosphofructokinase isoforms in isolated rat pancreatic islets and purified beta cells and cloning and expression of the rat phosphofructokinase-A isoform

We prepared polymers having a phospholipid polar group, poly [omega-methacryloyloxyalkyl phosphorylcholine (MAPC)-co-n-butyl methacrylate(BMA)], as new biomedical materials and evaluated their blood compatibility with attention to protein adsorption and platelet adhesion. The total amount of proteins adsorbed on the polymer surface from human plasma was determined, and the distribution of adsorbed proteins on the plasma-contacting surface was analyzed. The amount of proteins adsorbed on every poly (MAPC-co-BMA) was small compared with that observed on polymers without the phospholipid polar group. However, there was no significant difference in the amount of adsorbed proteins on the poly(MAPC-co-BMA) even when the methylene chain length between the phospholipid polar group and the backbone in the MAPC moiety was altered. Platelet adhesion on the polymer surface from a platelet suspension in a buffered solution was evaluated with and without plasma treatment on the surface. When a rabbit platelet suspension was brought into contact with the poly(BMA) surface after treatment with plasma, many platelets adhered and aggregated. However, a reduced amount of platelet adhered on the poly(BMA) was found in the case of direct contact with the platelet suspension. On the other hand, the poly(MAPC-co-BMA)s could inhibit platelet adhesion under both conditions. Based on these results, it can be concluded that the proteins adsorbed on the surface play an important role in determining the platelet adhesion and suppression of the protein adsorption on the surface, which is one of the most significant ways of inhibiting platelet adhesion.     

一种简便的评定引战配合效率方法

在导弹近炸引信起爆延时具有随机性基础上，本文建立了一种用延时及其数学特征表示的评定引战配合效率的简便方法，并对有关应用问题进行了讨论。     

A Novel Athermal 40-Channel DWDM Multi/Demultiplexer Based on the Combination of AWGs and Interleaver

An athermal 40-channel dense wavelength-division-multiplexing multi/demultiplexer using a novel combination technology is proposed. It consists of one 1times4 100- to 400-GHz spacing interleaver filter and four sub-arrayed-waveguide gratings (AWGs). The temperature-dependent wavelength shift of the combined device is successfully suppressed to 0.058 nm in the -20degC to 70degC temperature range. Moreover, the combined device's adjacent crosstalk (typically -35 dB) is much better than conventional AWGs (typically -25 dB).