Mutations in the ligand-binding domain of the kit receptor: an uncommon site in human piebaldism

Heterozygous mutations in the gene for the Kit transmembrane receptor have been identified recently in human piebaldism and mouse "dominant spotting." Interestingly, all of the 14 known missense mutations that cause depigmentation in these species map to the tyrosine kinase domain of the receptor, whereas none have involved the extracellular ligand-binding domain. In an attempt to detect these uncommon mutations, we screened the nine exons encoding the extracellular portion of Kit for single-strand conformation polymorphisms (SSCP) in eight piebald subjects previously reported to be negative for kinase mutations. Four of these eight kindreds proved to carry novel mutations. The first mutation, found in two apparently unrelated probands with mild piebaldism and English ancestry, substitutes an arginine for a highly conserved cysteine at codon 136. This substitution disrupts a putative disulfide bond required for formation of the second Ig-like (D2) loop of the Kit ligand-binding domain. The second mutation, detected in a piebald kindred characterized by unusually limited depigmentation, substitutes a threonine for an alanine at codon 178, a site just proximal to conserved cysteines at codons 183 and 186. The third mutation, occurring in a kindred with more extensive depigmentation, is a novel four-base insertion in exon 2 that results in a proximal frameshift and premature termination. The data strongly suggest that piebaldism can result from missense mutations in the Kit ligand-binding domain, although the resulting phenotype may be milder than that observed for null or kinase mutations. The apparent clustering of these uncommon mutations at or near the conserved cysteines for the D2 Ig-like loop further suggests a critical role for this region in Kit receptor function.     

Research on the group decision-making about emergency event based on network technology

In order to improve decision-making efficiency about emergency event, this paper proposes a novel concept, i.e., Agile-Delphi Method, which is an integration of agile decision and Delphi Method implicating that the decision-makers instantly deliver, respond, treat, and utilize information via Delphi process while conducting group decision-making about emergency event. The paper details the mechanism of group decision-making about emergency event based on network technology and Agile-Delphi Method. Finally, the paper conducts an empiric analysis taking the “111 event”, i.e., the liquid ammonia spill event happened on November 1, 2006 in a phosphorus chemical company in China, as an example.     

基于罚函数的解析目标分流法计算特性分析

为了在复杂产品早期开发阶段更好的使用解析目标分流法(ATC),分析了基于不同罚函数的ATC方法的计算特性.给出了ATC方法的一般公式,比较了3种ATC方法的优缺点,以常用的几何规划算例为例,研究了初值、初始罚参数、收敛准则等因素对计算精度和计算花费的影响.计算结果表明,ATC是一种稳定性好、计算效率高的多学科设计优化(MDO)方法,并且基于增广拉格拉日函数的ATC方法的总体性能比其它两种方法要好一些.     

Stability and synchronization for Markovian jump neural networks with partly unknown transition probabilities

This paper addresses the problems of stability and synchronization for a class of Markovian jump neural networks with partly unknown transition probabilities. We first study the stability analysis problem for a single neural network and present a sufficient condition guaranteeing the mean square asymptotic stability. Then based on the Lyapunov functional method and the Kronecker product technique, the chaos synchronization problem of an array of coupled networks is considered. Both the stability and the synchronization conditions are delay-dependent, which are expressed in terms of linear matrix inequalities. The effectiveness of the developed methods is shown by simulation examples.     

Multi-sensor calibration through iterative registration and fusion

In this paper, a new multi-sensor calibration approach, called iterative registration and fusion (IRF), is presented. The key idea of this approach is to use surfaces reconstructed from multiple point clouds to enhance the registration accuracy and robustness. It calibrates the relative position and orientation of the spatial coordinate systems among multiple sensors by iteratively registering the discrete 3D sensor data against an evolving reconstructed B-spline surface, which results from the Kalman filter-based multi-sensor data fusion. Upon each registration, the sensor data gets closer to the surface. Upon fusing the newly registered sensor data with the surface, the updated surface represents the sensor data more accurately. We prove that such an iterative registration and fusion process is guaranteed to converge. We further demonstrate in experiments that the IRF can result in more accurate and more stable calibration than many classical point cloud registration methods.     

Performance-First Control for Discrete-Time LQG Problems

Performance-first control for discrete-time LQG is considered in this paper to minimize the probability that the performance index exceeds a preselected threshold via constructing a closed-loop feedback control law. This problem can be converted into a mean-variance control problem which can be solved by developing a nested form of the variance and using polynomial optimization as a solution scheme.     

基于PIC16F877A的变频恒压供水控制器设计

分析了高层建筑供水控制系统的技术要求,介绍了基于PIC16F877A单片机的变频恒压供水控制器的工作原理,提出了该装置的软硬件设计方法.相比目前的变频恒压控制系统,该装置的精简硬件设计有效地克服了系统可靠性差的问题;同时,基于PSO-PID智能算法的软件设计解决了系统动态响应慢和压力调节不稳定的缺点.该装置成本低、智能化程度高,生产实际中能够确保设备的使用寿命、能源的有效利用和供水质量.因此,具有很高的推广、应用价值.     

基于矢量模型的语音线性预测研究

研究语音参数线性预测的并行处理问题。通过把语音源序列的相邻样本分组能够构成一个均方差平稳的语音向量自回归序列,在Hilbert空间中运用正交投影原理导出具有高度并行处理能力的一预测编码策略,由此可推出参数线性预测的并行处理自适应算法。同传统格型算法相比,这种算法的计算复杂度及存贮量有明显改善。最后通过仿真运算检测了算法的性能。     

TD-SCDMA无线网络控制系统——传输信道转换的软件设计与实现

分析了TD-SCDMA无线接入系统的主要特征。介绍了TD-SCDMA系统中资源优化的意义以及无线传输信道转换的方法,设计实现了一套根据不同的Qos的进行无线资源与网络带宽动态配置的软件系统。重点介绍了无线传输信道转换的系统结构和主要关键技术。