计算机及网络技术与现代继续临床医学教育

计算机网络技术是现代信息技术的核心内容,其运用于现代临床医学教育前景广阔,不但适用范围广,教学效率也相当的高。计算机多媒体是现代临床教学的重要手段,而网络技术的使用特使教学内容噩方式发生根本性变革。根据目前计算机技术已深入到医学诊断、治疗及科研领域且发展迅速的现状,提出在继续医学教育中开展计算机知识学习的问题,并针对不同年龄段卫生工作者的具体情况进行了探讨并提出了相应的对策,这对于提高卫生工作者的综合素质也有着重要的意义。     

New insights on survivability in multi-domain optical networks

With the development of intelligent optical networks and the general multi-protocol label switching (GMPLS) technique, the seamless convergence between IP network and optical network is no longer be a dream but a practical reality. Similar to the Internet, current optical networks have been divided into multiple domains each of which has its own network provider and management policy. Therefore, the development of multi-domain optical networks will be the trend of new-generation intelligent optical networks, and GMPLS-based survivability for multi-domain optical networks will become a hot topic of research in the future. This paper provides a comprehensive review of the existing survivable schemes in multi-domain optical networks and analyzes the shortcomings of current research. Based on previous studies, we present possible challenges and propose new ideas to design efficient survivable schemes to guide the future work of researchers in multi-domain optical networks.     

基于ASP.NET的水稻分子育种信息平台管理系统

为实现水稻生物学数据的共享、交流和利用,基于ASP.NET,结合国内外水稻分子育种研究的现状和需求,构建了水稻分子育种信息平台.系统平台设计了基因库、QTL库和Ontology等多个子库和模块,并针对生物学数据的特点,采用B/S架构,运用存储过程和分页技术等多重手段,实施了客户端和服务器端双重安全屏障.对系统的实现技术、实现方案和优化设计等进行了详细的讨论和阐述.     

Computational simulation of Belousov–Zhabotinskii oscillating chemical reaction

The suitability of computational simulation of the Belousov–Zhabotinskii oscillating chemical reaction by differential kinetic methodology for resolving nonlinear multi-component system is demonstrated in this work. According to the Field–KÖrÖs–Noyes mechanism and the Oregonator model, the change of the concentrations of HBrO₂, bromide ion and cerium ion are simulated. The results of computational simulation are consistent with experimental results very well. At the same time, the effect of variables and parameters, especially the rate constant on the oscillation curve, are investigated deeply. A simple method of estimating rate constants is obtained through simulation the concentrations of key components of the system, and then comparison the simulation results with the experimental ones. The reasonable rate constant is also proposed.     

基于事件通知服务的RFID数据处理框架

RFID技术能够实现物理对象的实时标识、定位和监控,为了达到这个目标,必须能够高效地合成RFID基本事件并且有效地发布信息.RFID应用的多样化又需要一个能够通用的RFID数据处理框架.文中提出一个基于事件通知服务的RFID数据处理框架,并设计了一种基于匹配树的RFID复杂事件检测方法应用于该框架.通过对某汽车企业制造过程用例分析,来说明本框架的应用可行性.     

对新简化差别矩阵的研究

通过反例证明当决策表含不一致对象时,无法通过简化差别矩阵得到正确的核和约简.产生该问题的原因在于简化差别矩阵和简化决策表对不一致对象的处理均存在欠缺.提出新简化差别矩阵(NSDM)定义,通过利用新简化决策表把一致对象和不一致对象分开存放的特点修正了这两处缺陷.NSDM能够处理含多种不一致对象的决策表,并且能够得到正确的核和约简.利用前人的基于差别矩阵的求核和求约简算法分别以NSDM和简化差别矩阵为基础求核和约简,然后再利用核和约简的定义求核和约简,通过比较证明以NSDM为基础得到的核和约简是正确的.这说明NSDM可以有效地处理不一致对象并且通过NSDM能够得到正确的核和约简.这个实验同时验证了原有的以差别矩阵为基础的求核和求约简的算法不加改动就可以在新差别矩阵上使用.     

无线传感器网络路由协议及安全问题研究

无线传感器网络在军事和民用领域得到广泛的应用。由于传感器节点的资源有限以及通信的开放性使得其安全性显得尤为重要。出于对能量消耗的考虑,目前的路由协议设计得比较简单,作者对路由的安全性能以及可能受到的攻击进行分析,并给出相应的防范对策。     

计及用电行为模式的区域商业建筑负荷预测方法

为充分利用智能电表采集的细粒负荷数据并提高区域商业建筑负荷预测的精确度,提出一种基于用电行为模式的区域商业建筑负荷预测方法。首先,基于均值方差归一化方法对采集到的负荷数据进行标准化处理,通过肘方法确定聚类数目后进行k-Shape聚类,实现区域商业建筑负荷不同用电行为模式的提取;其次,针对大规模商业建筑负荷预测问题,考虑区域内大量商业建筑负荷预测时耗费大量内存资源却难以实现较准确预测问题,提出一种改进的Informer模型,该模型通过聚类算法识别具有相似用电行为模式的商业建筑,并充分考虑智能电表采集的异常负荷数据对模型训练结果的影响,能够良好的解决大规模商业建筑负荷预测精度不高问题;最后,采用加利福尼亚州商业建筑负荷进行实验,实验结果表明所提方法能够有效提高区域商业建筑负荷预测精度。     

基于微波无线能量传输多径效应的多角度超表面能量收集器

文中深入研究了基于微波无线能量传输技术的多径效应及其对多角度超表面能量收集器的性能的影响。首先,概述了微波无线能量传输技术的基本原理与发展现状,随后详细讨论了超表面结构在多角度能量接收中的应用。通过理论分析与仿真实验,文中提出了一种优化的超表面设计方案,以提高能量收集效率。实验结果显示,该方案能显著提高多角度超表面能量收集器在复杂传播环境下的能量收集性能,不仅为超表面能量收集器的设计提供了新的视角,也为未来无线能量传输技术的发展提供了理论参考。     

Macrophage Membrane-Coated Nanoparticles Sensitize Glioblastoma to Radiation by Suppressing Proneural–Mesenchymal Transformation in Glioma Stem Cells

Radiotherapy is identified as a crucial treatment for patients with glioblastoma, but recurrence is inevitable. The efficacy of radiotherapy is severely hampered partially due to the tumor evolution. Growing evidence suggests that proneural glioma stem cells can acquire mesenchymal features coupled with increased radioresistance. Thus, a better understanding of mechanisms underlying tumor subclonal evolution may develop new strategies. Herein, data highlighting a positive correlation between the accumulation of macrophage in the glioblastoma microenvironment after irradiation and mesenchymal transdifferentiation in glioblastoma are presented. Mechanistically, elevated production of inflammatory cytokines released by macrophages promotes mesenchymal transition in an NF-κB-dependent manner. Hence, rationally designed macrophage membrane-coated porous mesoporous silica nanoparticles (MMNs) in which therapeutic anti-NF-κB peptides are loaded for enhancing radiotherapy of glioblastoma are constructed. The combination of MMNs and fractionated irradiation results in the blockage of tumor evolution and therapy resistance in glioblastoma-bearing mice. Intriguingly, the macrophage invasion across the blood-brain barrier is inhibited competitively by MMNs, suggesting that these nanoparticles can fundamentally halt the evolution of radioresistant clones. Taken together, the biomimetic MMNs represent a promising strategy that prevents mesenchymal transition and improves therapeutic response to irradiation as well as overall survival in patients with glioblastoma.