DOC‐LS,a new liposome for dermal delivery,and its endocytosis by HaCaT and CCC‐ESF‐1 cells

The main objective of this work was to investigate the uptake channels of skin cells through which coumarin 6, transported by deoxycholate‐mediated liposomes (DOC‐LS), was internalised; this was also compared against the action of conventional LS. Coumarin 6‐loaded DOC‐LS and LS were characterised for size distribution, zeta potential, and shape, and analysed in vitro in human epidermal immortal keratinocyte (HaCaT) (epidermal) and human embryonic skin fibroblast (CCC‐ESF‐1) (dermal) cell lines. Various endocytosis inhibitors were incubated with cells treated with the nanocarriers. Flow cytometry results indicated that HaCaT and CCC‐ESF‐1 cells internalise the tested preparations through pinocytotic vesicles, macropinocytosis, clathrin‐mediated endocytic pathways, and via lysosomes, which consume a considerable amount of energy. The endocytosis pathways of DOC‐LS and LS showed no difference. This study provides a basis for the application of LS being combined with a microneedle system for efficient intracellular drug delivery, targeting cutaneous histocyte disorders.Inspec keywords: drugs, nanoparticles, lipid bilayers, nanomedicine, biomedical materials, electrokinetic effects, biomembrane transport, drug delivery systems, skin, organic compoundsOther keywords: dermal delivery, CCC‐ESF‐1 cells, skin cells, deoxycholate‐mediated liposomes, coumarin 6‐loaded DOC‐LS, endocytosis inhibitors, clathrin‐mediated endocytic pathways, endocytosis pathways, HaCaT cell lines, size distribution, zeta potential, nanocarriers, flow cytometry, pinocytotic vesicles, macropinocytosis, microneedle system, efficient intracellular drug delivery, targeting cutaneous histocyte disorders     

Revisiting the security of secure direct communication based on ping-pong protocol[Quantum Inf. Process. 8, 347 (2009)]

A. Chamoli and C.M. Bhandari presented a secure direct communication based on ping-pong protocol[Quantum Inf. Process. 8, 347 (2009)]. M.Naseri analyzed its security and pointed out that in this protocol any dishonest party can obtain all the other one’s secret message with zero risk of being detected by using fake entangled particles (FEP attack) [M. Naseri, Quantum Inf. Process. online]. In this letter, we reexamine the protocol’s security and discover that except the FEP attack, using a special property of GHZ states, any one dishonest party can also take a special attack, i.e., double-CNOT(Controlled NOT) attack. Finally, a denial-of-service attack is also discussed.     

基于以太网的RS-485总线构造物联网系统可行性的探析

RS485总线是工业中常用的通讯总线,相比RS232总线,其具有传输距离远、成本低等优势;以太网是互联网中最主流的组网方式。通过RS485总线与以太网混合,构建物联网系统,可低成本高效率地整合校园内各末端设备和设施。     

Impact of DEM accuracy and resolution on topographic indices

Topography is an important land-surface characteristic that affects most aspects of the water balance in a catchment, including the generation of surface and sub-surface runoff; the flow paths followed by water as it moves down and through hillslopes and the rate of water movement. All of the spatially explicit fully distributed hydraulic and hydrological models use topography (represented by the DEM of the area modelled) to derive bathymetry. DEM is also used to derive some other key information critical in fully distributed hydraulic and hydrological models.With high-resolution DEMs such as LiDAR (Light Detection and Ranging) becoming more readily available and also with the advancements in computing facilities which can handle these large data sets, there is a need to quantify the impact of using different resolution DEMs (e.g. 1 m against 10 m or 25 m) on hydrologically important variables and the loss of accuracy and reliability of the results as we move from high resolution to coarser resolution.The results from statistical analysis carried out to compare field survey elevations with the LiDAR DEM-derived elevations, show that there are small differences between the two data sets but LiDAR DEM is a reasonably good representation of the actual ground surface compared to other commonly used DEMs derived from contour maps.The results from the analysis clearly show that the accuracy and resolution of the input DEM have serious implications on the values of the hydrologically important spatial indices derived from the DEM. The result also indicates that the loss of details by re-sampling the higher resolution DEM to coarser resolution are much less compared to the details captured in the commonly available coarse resolution DEM derived from contour maps. Topographic indices based on contour derived DEMs should be used with caution and where available, the higher resolution DEM should be used instead of the coarse resolution one.     

Globally Exponential Stability for Delayed Neural Networks Under Impulsive Control

In this paper, the dynamic behaviors of a class of neural networks with time-varying delays are investigated. Some less weak sufficient conditions based on p-norm and ∞-norm are obtained to guarantee the existence, uniqueness of the equilibrium point for the addressed neural networks without impulsive control by applying homeomorphism theory. And then, by utilizing inequality technique, Lyapunov functional method and the analysis method, some new and useful criteria of the globally exponential stability with respect to the equilibrium point under impulsive control we assumed are derived based on p-norm and ∞-norm, respectively. Finally, an example with simulation is given to show the effectiveness of the obtained results.     

Fire detection based on hidden Markov models

In this paper, a novel method of real-time fire detection based on HMMs is presented. First, we present an analysis of fire characteristics that provides evidence supporting the use of HMMs to detect fire; second, we propose an algorithm for detecting candidate fire pixels that entails the detection of moving pixels, fire-color inspection, and pixels clustering. The main contribution of this paper is the establishment and application of a hidden Markov fire model by combining the state transition between fire and non-fire with fire motion information to reduce data redundancy. The final decision is based on this model which includes training and application; the training provides parameters for the HMM application. The experimental results show that the method provides both a high detection rate and a low false alarm rate. Furthermore, real-time detection has been effectively realized via the learned parameters of the HMM, since the most time-consuming components such as HMM training are performed off-line.     

一种低功耗集中供热实时温度采集系统设计

从系统性能,运行效率和经济效益等方面出发,设计出一种低功耗的多路温度采集与实时检测系统,既可为供热部门提供实际温度参数,合理调度锅炉运行时间,降低能耗;又可以为监管部门提供可靠的供热质量信息,方便协调和管理,化解供需的矛盾。具有较好的经济效益和社会效益。     

基于ARM的消防设备无线联网终端硬件设计

信息网络化的社会,消防报警设备的网络化是大势所趋。为了不浪费现行的消防联动设备资源,研究设计出一套基于ARM的硬件平台,集成了无线通信模块和图像采集模块。采用低成本硬件,达到系统功能要求。     

路径规划算法的改进及在车载导航中的应用

路径规划算法是车载导航的核心问题。充分利用启发式搜索具有方向性的启发信息,对A＊算法进行改进,采用双向的A＊算法来避免过多的节点搜索和搜索过界,不能得到正确结果的问题。同时,为了适合嵌入式平台的特殊环境,采用数据分层,搜索过程升层的方法,充分利用内存资源,减少外存I/O的工作量。并且结合上述策略,给出了改进的算法伪代码流程并对改进的A＊算法的进行验证。     

基于PID反馈的高Q值加速度计闭环检测电路

高Q值加速度计由于能够很好地降低热机械布朗噪声,被广泛应用于高精度低噪声检测领域,相应的闭环接口电路却成为其应用的困难之一.通过分析传感器的器件结构和动态响应,提出了一种基于PID反馈的闭环检测电路来克服传感器因高Q值造成的不利影响,改善系统的频率特性和动态响应.根据设计原理设计和测试了基于PCB板级的闭环检测电路.电...