Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism

As the most recent melanocortin receptor (MCR) identified, melanocortin-5 receptor (MC5R) has unique tissue expression patterns, pharmacological properties, and physiological functions. Different from the other four MCR subtypes, MC5R is widely distributed in both the central nervous system and peripheral tissues and is associated with multiple functions. MC5R in sebaceous and preputial glands regulates lipid production and sexual behavior, respectively. MC5R expressed in immune cells is involved in immunomodulation. Among the five MCRs, MC5R is the predominant subtype expressed in skeletal muscle and white adipose tissue, tissues critical for energy metabolism. Activated MC5R triggers lipid mobilization in adipocytes and glucose uptake in skeletal muscle. Therefore, MC5R is a potential target for treating patients with obesity and diabetes mellitus. Melanocortin-2 receptor accessory proteins can modulate the cell surface expression, dimerization, and pharmacology of MC5R. This minireview summarizes the molecular and pharmacological properties of MC5R and highlights the progress made on MC5R in energy metabolism. We poInt. out knowledge gaps that need to be explored in the future.     

Phloroglucinol Derivative Carbomer Hydrogel Accelerates MRSA-Infected Wounds’ Healing

Globally, wound infection is considered to be one of the major healthcare problems, with bacterial infections being the most critical threat, leading to poor and delayed wound healing, and even death. As a superbug, methicillin-resistant Staphylococcus aureus (MRSA) causes a profound hazard to public health safety, prompting us to search for alternative treatment approaches. Herein, the MTT test and Hoechst/propidium iodide (PI) staining demonstrated that PD was slightly less toxic to human fibroblasts including Human keratinocytes (HaCaT) cell line than Silver sulfadiazine (SSD), and Vancomycin (Van). In the MRSA-infected wound model, PD hydrogel (1%, 2.5%) was applied with for 14 days. The wound healing of PD hydrogel groups was superior to the SSD, Van, and control groups. Remarkably, the experimental results showed that PD reduced the number of skin bacteria, reduced inflammation, and upregulated the expression of PCNA (keratinocyte proliferation marker) and CD31 (angiogenesis manufacturer) at the wound site by histology (including hematoxylin–eosin (HE) staining, Masson staining) and immunohistochemistry. Additionally, no toxicity, hemocompatibility or histopathological changes to organs were observed. Altogether, these results suggested the potential of PD hydrogel as a safe, effective, and low toxicity hydrogel for the future clinical treatment of MRSA-infected wounds.     

Optimizing wheel profiles and suspensions for railway vehicles operating on specific lines to reduce wheel wear: a case study

Multibody System Dynamics - The selection of a wheel profile is a topic of great interest as it can affect running performances and wheel wear, which needs to be determined based on the actual...     

用于天线阵馈电的高隔离度一分八不等比功分器设计

随着阵列天线研制技术的发展,对馈电网络的特性提出了更高的要求,然而关于Ku波段高隔离度不等比天线阵馈电网络的文献却不是很多.利用两级λ/4阻抗变换器级联实现功分器频带展宽,利用两级隔离电阻提高端口隔离度,通过在3λ/4阻抗变换线上开槽实现结构紧凑的一分二不等比功分器.在此基础上,由三级两路功率分配器级联构成Ku波段高隔离度一分八不等比功分器.该功分器已成功应用于天线阵馈电网络的设计.     

基于调峰形势的联络线受电模型及其优化

探讨了基于调峰形势的联络线受电优化模型。该模型根据负荷预测数据,采用分时电价计算方法,综合考虑电网内机组的发电、联络线受电和调峰能力三者的关系,在保证电网安全的条件下,得到了经济效益优化的受电曲线,从而改变了以往受电曲线由人工凭经验制定的状况,为电网的安全经济运行提供了技术依据。     

干式空心电抗器的作用和使用寿命

概述了电抗器的作用 ,介绍了外界条件对电抗器使用寿命的影响     

彩色亮度设计及其在颜色仿真中的应用

本文基于颜色仿真的要求,设计了彩色亮度计并编制了计算机程序进行颜色存储,可作为颜色标准和物体色的计算机存储,介绍了设计的思路,描述了系统硬件,软件以及为检测微弱信号,提高系统可靠性所采取的各种措施,改进了色度修正的方法并给出了相应公式。     

应用低功耗射频收发机构建新型RFID安全监测系统及其应用

本文重点对用低功耗射频收发机所构建的有源RFID和无源RFID安全监测系统与应用作分析说明。     

AFRP筋混凝土粘结强度和锚固长度的试验研究

通过对27个拉拔试件和16个梁式试件的试验,探讨AFRP筋与混凝土的粘结滑移关系、粘结强度,并且综合分析其他文献的结果,提出简化的局部粘结滑移本构关系和拔出破坏模式下锚固长度的计算公式。