BID: a novel BH3 domain-only death agonist

The BCL-2 family of proteins consists of both antagonists (e.g., BCL-2) and agonists (e.g., BAX) that regulate apoptosis and compete through dimerization. The BH1 and BH2 domains of BCL-2 are required to heterodimerize with BAX and to repress cell death; conversely, the BH3 domain of BAX is required to heterodimerize with BCL-2 and to promote cell death. To extend this pathway, we used interactive cloning to identify Bid, which encodes a novel death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL-2). BID possesses only the BH3 domain, lacks a carboxy-terminal signal-anchor segment, and is found in both cytosolic and membrane locations. BID counters the protective effect of BCL-2. Moreover, expression of BID, without another death stimulus, induces ICE-like proteases and apoptosis. Mutagenesis revealed that an intact BH3 domain of BID was required to bind the BH1 domain of either BCL-2 or BAX. A BH3 mutant of BID that still heterodimerized with BCL-2 failed to promote apoptosis, dissociating these activities. In contrast, the only BID BH3 mutant that retained death promoting activity interacted with BAX, but not BCL-2. This BH3-only molecule supports BH3 as a death domain and favors a model in which BID represents a death ligand for the membrane-bound receptor BAX.     

吸附法脱除乙烯中少量氧气的吸附剂研究

采用重量法在电子天平上研究了Ｃ２Ｈ４和Ｏ２单组份在５Ａ、１３Ｘ、丝光沸石和碳分子筛等不同吸附剂上的吸附平衡性质和扩散动力学性质。结果表明，在沸石类吸附剂上，Ｃ２Ｈ４的平衡吸附量远大于Ｏ２的平衡吸附量，Ｃ２Ｈ４的吸附扩散速率也大于Ｏ２的扩散速率；在碳分子筛吸附剂上Ｃ２Ｈ４的平衡吸附量大于Ｏ２的平衡吸附量，但Ｏ２的吸附扩散速率远大于Ｃ２Ｈ４的扩散速率，其扩散系数是Ｃ２Ｈ４的２３９倍。单柱评价结果表明，Ｃ２Ｈ４－Ｏ２混合组份通过该碳分子筛吸附剂时，Ｏ２的破点时间长，Ｃ２Ｈ４的纯度可达１００％。加压有利于选择吸附Ｏ２，而且加压吸附、常压脱附再生性能好。该碳分子筛是脱除高浓度乙烯中少量氧气的理想吸附剂。     

上海市吴淞工业区大气PM2.5水溶成分的元素分析及细胞毒性研究

通过ICP-MS测定了上海市吴淞地区大气PM2.5水溶成分金属元素含量,通过四唑盐(MTT)测定细胞存活率,通过超氧化歧化酶(SOD)和丙二醛(MDA)两个指标测定细胞氧化损伤,琼脂糖凝胶电泳测定细胞内DNA损伤,流式细胞仪(Flow cytometry)检测细胞凋亡和周期等实验研究了大气PM2.5水溶成分的细胞毒性.实验结果表明:PM2.5可溶成分中Zn元素含量最高,PM2.5在一定浓度范围内能导致细胞死亡,引起细胞的氧化损伤,影响DNA的复制,阻碍细胞增殖,但没有诱导细胞凋亡.PM2.5中可溶金属离子对细胞毒性表现为联合作用.     

清洁汽油的研究与生产技术Ⅱ. 生产清洁汽油的非加氢精制技术进展

对国内外生产清洁汽油的非加氢精制技术，如异构化、烷基化、吸附脱硫、生物催化脱硫、碱性抽提脱硫等进行了综述．介绍了汽油清净剂及乙醇汽油的开发使用情况。针对国内清洁汽油生产技术现状，提出了增强自主创新能力，加快间接烷基化技术、催化裂化汽油吸附脱硫工艺及高选择性降硫助剂研发力度的建议。     

Estimating point-to-point and point-to-multipoint traffic matrices: an information-theoretic approach

Traffic matrices are required inputs for many IP network management tasks, such as capacity planning, traffic engineering, and network reliability analysis. However, it is difficult to measure these matrices directly in large operational IP networks, so there has been recent interest in inferring traffic matrices from link measurements and other more easily measured data. Typically, this inference problem is ill-posed, as it involves significantly more unknowns than data. Experience in many scientific and engineering fields has shown that it is essential to approach such ill-posed problems via "regularization". This paper presents a new approach to traffic matrix estimation using a regularization based on "entropy penalization". Our solution chooses the traffic matrix consistent with the measured data that is information-theoretically closest to a model in which source/destination pairs are stochastically independent. It applies to both point-to-point and point-to-multipoint traffic matrix estimation. We use fast algorithms based on modern convex optimization theory to solve for our traffic matrices. We evaluate our algorithm with real backbone traffic and routing data, and demonstrate that it is fast, accurate, robust, and flexible.     

鲑鱼皮制革工艺的研究

前言随着淡水养殖的逐年增加和不断发展,淡水鱼的深加工也在迅速发展,作为副产品之一的鱼皮会越来越多,从而确保了鱼皮制革原料的稳定,鱼皮制革的长足发展势在必行。从皮革制品的市场分析,随着广大消费者对皮革制品认知程度的加深,鱼皮革制品的市场也越来越广阔。天然鲑鱼皮革的各项理化指标,均可达到同类型牛羊皮革制品的指标,而且以其轻软、薄透、结实耐用的特点,特别是人工难以模仿的独特自然花纹,而得到广大消费者的青睐。用鲑鱼革制成的箱包、票夹、皮鞋、服装饰品等都是高档消费品,除了具有实用价值以外,还具有艺术价值。作为一种新型…     

Electromagnetic reflection and transmission from a new version of Cantor fractal nonlinear multilayers

In this paper, we put forward a new version of Cantor fractal multilayers, which are nonlinear medium, and investigate its properties of reflection and transmission when a plane wave is obliquely incident upon it. A new exact self-similarity algorithm that make use of the self -similarity of these structure are developed. The results for different stages of fractal growth within the first-order nonlinear approximation are found. Compared with the traditional chain-matrix approach, the scheme provides the reflection and transmission coefficients for any stage (S) with much less calculation time on a personal computer.     

乡镇供水工程倒虹管施工安装新法

总结了乡镇供水工程中倒虹管施工安装的成功经验，推了一种新的施工安装方法－－预测镇墩沉管法，该方法经江西省万年县大港桥引水工程安装检验，是一种简单易行、经济可靠的施工安装方法。