Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification

Nowadays various inorganic nanoparticles that generate highly reactive hydroxyl radical ( · OH) on the basis of Fenton‐like catalytic activity of metal ions have been designed for chemodynamic therapy. However, the high level of adaptive antioxidants [glutathione (GSH)] in cancer cells could effectively consume · OH to compromise the treatment efficiency and biosafety of these inorganic nanoparticles, and this is a general concern in chemodynamic therapy. Herein, a new biodegradable nanoscale coordination polymer (NCP) is developed by integration of cisplatin prodrug (DSCP) and iron (III) ions through a reverse microemulsion method. The DSCP in the NCPs could react with GSH to release free cisplatin, while the iron (III) ions could be reduced by GSH into iron (II) to enable Fenton reaction, subsequently leading to amplified intracellular oxidative stress. After surface modification of polyethylene glycol (PEG) and cyclo[Arg‐Gly‐Asp‐D‐Phe‐Lys(mpa)] peptide (cRGD), Fe‐DSCP‐PEG‐cRGD shows an excellent targeting effect against α_vβ₃‐integrin overexpressed tumor cells. Furthermore, Fe‐DSCP‐PEG‐cRGD enables significant chemo and chemodynamic therapy with dramatically enhanced therapeutic efficiency in comparison to relative monotherapies. Importantly, Fe‐DSCP‐PEG‐cRGD could be efficiently cleared out from mice through feces and urine postinjection 7 days. The NCP presented in this work is simple and economical, which shows great biodegradability and biosafety for potential clinical translation.     

下一代家庭宽带互联技术简述

本文分析家庭互联的现状和主要宽带互联技术,总结下一代家庭宽带互联技术的融合发展趋势。     

分布式发电并网系统综述

随着分布式发电(Distributed Generation)应用的增加,越来越多的分布式发电正在接入电网,由此带来的并网问题日益重要:并网系统(包括硬件和软件)主要用来连接分布式发电和电网(通常是本地电网),本文主要讨论了分布式发电与电网之间的并网类型,并网系统的分类、功能、主要结构及采取的控制方法,并简要介绍了现有的分布式发电并网导则。     

FTTx中BAC设备组网方案研究

在接入网络"光进铜退"迅速推进的形势下,越来越多贴近用户的语音接入设备连人软交换网络.如何保证软交换网络的安全与服务质量是电信运营商关注的一大问题.本文介绍了软交换边缘接入控制(BAC)设备的定义、作用与网络中所处位置,根据现网中语音接入设备所处的不同场景提出了BAC设备的部署策略,并对未来应用的大容量BAC设备的组网方案进行了研究.     

形变热处理对中碳Cr-Ni-W-Mo钢组织及力学性能的影响

为进一步提高中碳Cr-Ni-W-Mo钢的强塑性,采用Gleeble 3500热模拟试验机在700 ℃温度下进行变形量为20%~50%的形变热处理（TMT）。利用扫描电镜、透射电镜、电子背散射衍射对试验钢组织进行表征,利用拉伸试验机对拉伸性能进行测试,研究TMT工艺对其组织演变和力学性能的影响。结果表明：试验钢在TMT后的组织是包含回火马氏体、下贝氏体、残余奥氏体的复相组织,随着形变量增加,下贝氏体组织及残余奥氏体含量、位错密度相应增加,板条宽度减小;在相变强化、细晶强化及位错强化共同作用下,随着形变量增加,试验钢的强度增加,塑性升高;当形变量为50%时屈服强度达到1 733 MPa,抗拉强度达到2 243 MPa,伸长率为12.66％,与传统热处理相比,分别提高28.18%、12.88%和50.35%,获得了良好的强塑性匹配。     

数字微波卫星车——实现快速反应的电视新闻制播平台

依据"新闻立台"的思想和实现新闻快速反应的目标,中山广播电视台设计制造了数字微波卫星车.本文主要介绍了数字微波卫星车的设计思想、功能模块设计和工艺设计方面的创新点,总结了该车的使用情况和社会经济效益.     

Bioinspired Intrinsic Versatile Hydrogel Fabricated by Amyloidal Toxin Simulant-Based Nanofibrous Assemblies for Accelerated Diabetic Wound Healing

Persistent microbial infection and decreased neovascularization are common issues associated with diabetic wound treatment. Hydrogel dressings that offer intrinsic antibacterial and angiogenesis-inducing may substantially avoid the use of antibiotics or angiogenic agents. Herein, a versatile hydrogel is fabricated using an amyloid-derived toxin simulant (Fmoc-LFKFFK-NH₂, FLN) as building blocks, inspired by the defense strategy of Staphylococcus aureus (S. aureus). The simulant assemblies of the hydrogel function as both matrix components and functional elements for diabetic wound treatment. The hydrogel undergoes quick assembly from random monomers to nanofibrils with abundant b-sheet driven by multiple non-covalent interactions. The developed hydrogel demonstrates excellent biocompatibility and accelerates angiogenesis via hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor A (VEGFA) signaling as a consequence of its amyloidal structure. The simulant-based nanofibrils endow the hydrogel with broad-spectrum antibacterial activity dominated by a membrane-disruption mechanism. In addition, the hydrogel exhibits excellent performance compared with the commercial hydrogel Prontosan in accelerating wound healing of diabetic mice infected with methicillin-resistant S. aureus (MRSA). This study highlights the fabrication of a single component and versatile hydrogel platform, thereby avoiding the drug-related side effects and complicated preparations and demonstrating its profound potential as a clinical dressing for the management of microbe-infected diabetic wounds.     

All‐in‐One Theranostic Nanoplatform Based on Hollow TaOx for Chelator‐Free Labeling Imaging,Drug Delivery,and Synergistically Enhanced Radiotherapy

Despite extensive use of radiotherapy in cancer treatment, there has been huge demand to improve its efficacy and accuracy in tumor destruction. To this end, nanoparticle‐based radiosensitizers, particularly those with high‐Z elements, have been explored to enhance radiotherapy. Meanwhile, imaging is an essential tool prior to the individual planning of precise radiotherapy. Here, hollow tantalum oxide (H‐TaOx) nanoshells are prepared using a one‐pot template‐free method and then modified with polyethylene glycol (PEG), yielding H‐TaOx‐PEG nanoshells for imaging‐guided synergistically enhanced radiotherapy. H‐TaOx‐PEG nanoshells show strong intrinsic binding with metal ions such as Fe³⁺ and ^99mTc⁴⁺ upon simple mixing, enabling magnetic resonance imaging and single photon emission computed tomography imaging, respectively, which are able to track in vivo distribution of those nanoshells and locate the tumor. With mesoporous shells and large cavities, those H‐TaOx‐PEG nanoshells show efficient loading of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), a hydrophobic chemotherapeutic drug. By means of the radiosensitization effect of Ta to deposit X‐ray energy inside tumors, as well as SN‐38‐induced cell cycle arrest into radiation‐sensitive phases, H‐TaOx‐PEG@SN‐38 can offer remarkable synergistic therapeutic outcome in the combined chemoradiotherapy. Without appreciable systemic toxicity, such hollow‐TaOx nanostructure may therefore find promising applications in multimodal imaging and enhanced cancer radiotherapy.     

光电耦合器件g-r噪声模型

在宽范围偏置条件下，测量了光电耦合器件的g-r（产生-复合）噪声．实验结果表明，随着偏置电流的增加，g-r噪声逐渐向高频移动，其噪声幅值呈现先增加后减小的变化规律．通过测量前级噪声和后级噪声，发现光电耦合器件g-r噪声来源于后级的光敏三极管．基于载流子数涨落机制，建立了一个光电耦合器件g-r噪声的定量分析模型．实验结果和本文模型符合良好．