全文获取类型
收费全文 | 1189篇 |
免费 | 64篇 |
国内免费 | 46篇 |
专业分类
电工技术 | 32篇 |
综合类 | 86篇 |
化学工业 | 222篇 |
金属工艺 | 53篇 |
机械仪表 | 48篇 |
建筑科学 | 49篇 |
矿业工程 | 16篇 |
能源动力 | 43篇 |
轻工业 | 63篇 |
水利工程 | 17篇 |
石油天然气 | 17篇 |
武器工业 | 4篇 |
无线电 | 109篇 |
一般工业技术 | 137篇 |
冶金工业 | 215篇 |
原子能技术 | 19篇 |
自动化技术 | 169篇 |
出版年
2023年 | 6篇 |
2022年 | 34篇 |
2021年 | 32篇 |
2020年 | 13篇 |
2019年 | 22篇 |
2018年 | 20篇 |
2017年 | 19篇 |
2016年 | 34篇 |
2015年 | 26篇 |
2014年 | 17篇 |
2013年 | 54篇 |
2012年 | 28篇 |
2011年 | 47篇 |
2010年 | 38篇 |
2009年 | 36篇 |
2008年 | 35篇 |
2007年 | 35篇 |
2006年 | 33篇 |
2005年 | 26篇 |
2004年 | 31篇 |
2003年 | 65篇 |
2002年 | 104篇 |
2001年 | 121篇 |
2000年 | 67篇 |
1999年 | 39篇 |
1998年 | 56篇 |
1997年 | 40篇 |
1996年 | 31篇 |
1995年 | 17篇 |
1994年 | 15篇 |
1993年 | 21篇 |
1992年 | 10篇 |
1991年 | 9篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1986年 | 10篇 |
1985年 | 12篇 |
1984年 | 4篇 |
1983年 | 10篇 |
1982年 | 6篇 |
1981年 | 7篇 |
1980年 | 6篇 |
1978年 | 7篇 |
1977年 | 4篇 |
1976年 | 8篇 |
1971年 | 2篇 |
1968年 | 2篇 |
1966年 | 3篇 |
排序方式: 共有1299条查询结果,搜索用时 15 毫秒
11.
Amir Mohammadzadeh Pter P. Lakatos Mihly Balogh Ferenc Zdor Dvid rpd Kardi Zoltn S. Zdori Kornl Kirly Anna Rita Galambos Szilvia Barsi Pl Riba Sndor Benyhe Lszl Kles Tams Tbi va Szk Laszlo G. Harsing Jr. Mahmoud Al-Khrasani 《International journal of molecular sciences》2021,22(5)
The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study NFPS and Org-25543, GlyT-1 and GlyT-2 inhibitors, respectively and their combination in rat mononeuropathic pain evoked by partial sciatic nerve ligation. Cerebrospinal fluid (CSF) glycine content was also determined by capillary electrophoresis. Subcutaneous (s.c.) 4 mg/kg NFPS or Org-25543 showed analgesia following acute administration (30–60 min). Small doses of each compound failed to produce antiallodynia up to 180 min after the acute administration. However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment. Co-treatment with subanalgesic doses of NFPS (1 mg/kg) and Org-25543 (2 mg/kg) produced analgesia at 60 min and thereafter meanwhile increased significantly the CSF glycine content. This combination alleviated NP without affecting motor function. Test compounds failed to activate G-proteins in spinal cord. To the best of our knowledge for the first time we demonstrated augmented analgesia by combining GlyT-1 and 2 inhibitors. Increased CSF glycine content supports involvement of glycinergic system. Combining selective GlyT inhibitors or developing non-selective GlyT inhibitors might have therapeutic value in NP. 相似文献
12.
13.
Aneta Kaczor Nikoletta Szemerédi Dr. Katarzyna Kucwaj-Brysz Dr. Monika Dąbrowska Dr. Małgorzata Starek Dr. Gniewomir Latacz Dr. Gabriella Spengler Prof. Jadwiga Handzlik 《ChemMedChem》2021,16(15):2386-2401
ABCB1 modulation is an interesting strategy in the search for new anticancer agents that can overcome multidrug resistance (MDR). Hence, 17 new 5-arylideneimidazolones containing an amine moiety, as potential ABCB1 inhibitors, were designed, synthesized, and investigated. The series was tested in both parental (PAR) and multidrug-resistant (MDR) ABCB1-overexpressing T-lymphoma cancer cells using cytotoxicity assays. The ABCB1-modulating activity was examined in rhodamine 123 accumulation tests, followed by Pgp-Glo™ Assay to determine the influence of the most active compounds on ATPase activity. Lipophilic properties were assessed both, in silico and experimentally (RP-TLC). Pharmacophore-based molecular modelling toward ABCB1 modulation was performed. The studies allowed the identification of anticancer agents (p-fluorobenzylidene derivatives) more potent than doxorubicin, with highly selective action on MDR T-lymphoma cells (selectivity index >40). Most of the investigated compounds showed ABCB1-modulating action; in particular, two 5-benzyloxybenzylidene derivatives displayed activity nearly as strong as that of tariquidar. 相似文献
14.
Pellets containing metronidazole were produced in a centrifugal granulator, with hydroxypropylcellulose (Klucel LF®) as binding agent, and corn starch, microcrystalline cellulose (Vivapur 101®) and lactose as excipients. The wettability of the pharmaceutical powders was assessed by means of contact angle measurements, and the dispersive and polar surface energies were determined. The spreading coefficients, the work of adhesion and the work of cohesion were calculated and correlated with the pellet properties (friability, bulk and tapped density, and porosity). The aim was to investigate the role of the surface free energy of one- and two-component powder compositions in pellet production. The interactions between the particles were found to be connected with the measured pellet parameters. It was concluded that, in the course of the growth of the pellets, the particle sizes of the pharmaceutical powders and the interactions between them are important. If the work of cohesion of the binder is lower than the work of cohesion of the substrate and the work of adhesion, then the optimal amount of the binding agent is that which coats the particles uniformly in minimal quantity and in continuous layer. 相似文献
15.
Multiwalled carbon nanotubes (MWCNT) were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), and by adsorption of N2 and acetylene. The dynamics of acetylene sorption was studied by frequency response spectroscopy. The average tube dimension and the shell number were determined from a statistical evaluation of the TEM images. This value agreed with that obtained from XRD via the Scherrer equation only if a shape factor of 0.49 was used. The diffusion of acetylene in the nanotubes of the MWCNT sample was found to be the rate-controlling step of the sorption process. Relationships between the tube dimensions and the equilibrium and dynamic sorption properties were demonstrated. 相似文献
16.
烯唑醇含量分析方法的研究 总被引:1,自引:0,他引:1
烯唑醇含量分析试样用甲醇溶解 ,以邻苯二甲酸二乙酯为内标物 ,在ODS柱和紫外检测器上对试样中的烯唑醇进行高压液相色谱分离和测定。该方法定量准确 ,精密度较好 ,对烯唑醇原药同一样品进行十次重复测定 ,方法标准偏差为 0 .37,变异系数为 0 .38% ,回收率为 98.9%~ 10 0 .6 %。 相似文献
17.
Gábor Bacsó Ádám Visegrádi Attila Kertesz Zsolt Németh 《Journal of Grid Computing》2014,12(1):169-186
The ever growing number of computation-intensive applications calls for utilizing large-scale, potentially interoperable distributed infrastructures. Nowadays, such distributed systems enable the management of heterogeneous scientific workflows of considerable sizes, where job scheduling and resource management is a crucial issue. In this paper we focus on the challenges of scheduling parameter sweep applications, a specific and commonly used type of workflows where ordering of job executions is irrelevant. A parameter sweep has a large set of independent job instances, called a multi-job, submitted for execution in a single step. In order to cope with the high uncertainty and unpredictable load of resources, and the simultaneous submissions of multi-job instances, we propose a statistics-based brokering approach for allocating jobs to resources so that the makespan is minimised. Earlier studies claim that users’ predictions on job runtime are inaccurate and unusable for scheduling. Our aim is to examine, whether statistical trace data for the same purpose is efficient compared to randomized allocation. 相似文献
18.
19.
为实现绿色切削,研究了无污染、无危害的冷却润滑技术.采用氮气、氧气、二氧化碳气、氩气及过热水蒸气作冷却润滑剂,进行了单因素切削试验.试验结果表明,这些气体冷却润滑剂可以减小切削变形、切削力,降低切削温度,改善加工表面形貌.根据试验结果和冷却润滑作用机理分析可知,气体在切削中具有一定的冷却润滑作用,同时具有来源广泛、无毒害和污染、不用回收处理等绿色特点,故气体具备绿色切削的潜力. 相似文献
20.
A series of polymers based on methylmethacrylate, butylacrylate, and ω‐perfluorooctylalkylacrylate were prepared by radical polymerization. By changing both the length of the hydrocarbon spacer, between the fluorinated chain and the ester function of the fluorinated monomer, and its concentration, the surface properties of the resulting terpolymers were greatly influenced. Polymers containing small amounts of fluorinated comonomer units had considerably reduced surface energies compared to the copolymer poly (methylmethacrylate‐co‐butylacrylate) taken as reference. The outermost surface composition has been investigated by the XPS technique, confirming the strong fluorine enrichment. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 821–827, 2006 相似文献