Exploring brain connectivity with two-dimensional neural maps

We introduce two-dimensional neural maps for exploring connectivity in the brain. For this, we create standard streamtube models from diffusion-weighted brain imaging data sets along with neural paths hierarchically projected into the plane. These planar neural maps combine desirable properties of low-dimensional representations, such as visual clarity and ease of tract-of-interest selection, with the anatomical familiarity of 3D brain models and planar sectional views. We distribute this type of visualization both in a traditional stand-alone interactive application and as a novel, lightweight web-accessible system. The web interface integrates precomputed neural-path representations into a geographical digital-maps framework with associated labels, metrics, statistics, and linkouts. Anecdotal and quantitative comparisons of the present method with a recently proposed 2D point representation suggest that our representation is more intuitive and easier to use and learn. Similarly, users are faster and more accurate in selecting bundles using the 2D path representation than the 2D point representation. Finally, expert feedback on the web interface suggests that it can be useful for collaboration as well as quick exploration of data.     

Usable optimistic fair exchange

Fairly exchanging digital content is an everyday problem. It has been shown that fair exchange cannot be achieved without a trusted third party (called the Arbiter). Yet, even with a trusted party, it is still non-trivial to come up with an efficient solution, especially one that can be used in a p2p file sharing system with a high volume of data exchanged.We provide an efficient optimistic fair exchange mechanism for bartering digital files, where receiving a payment in return for a file (buying) is also considered fair. The exchange is optimistic, removing the need for the Arbiter’s involvement unless a dispute occurs. While the previous solutions employ costly cryptographic primitives for every file or block exchanged, our protocol employs them only once per peer, therefore achieving an O(n) efficiency improvement when n blocks are exchanged between two peers. Our protocol uses very efficient cryptography, making it perfectly suitable for a p-2-p file sharing system where tens of peers exchange thousands of blocks and they do not know beforehand which ones they will end up exchanging. Therefore, our system yields up to one-to-two orders of magnitude improvement in terms of both computation and communication (40 s vs. 42 min, 1.6 MB vs. 200 MB). Thus, for the first time, a provably secure (and privacy-respecting when payments are made using e-cash) fair exchange protocol can be used in real bartering applications (e.g., BitTorrent) [14] without sacrificing performance.     

Crack growth in transforming ceramics under cyclic tensile loads

The mechanisms of stable growth of short fatigue cracks (crack length up to 1 mm) at room temperature in magnesia-partially stabilized zirconia subjected to cyclic tensile loads were investigated. Single edge-notched specimens were fractured in the four-point bend configuration under cyclic and quasi-static tensile loads. At a load ratio of 0.1, the threshold stress intensity factor range, K, for fracture initiation in cyclic tension is as low as 3.4 M Pam^1/2, and catastrophic failure occurs at K=6.6 M Pam^1/2. For crack length less than 1 mm and for plane strain conditions, growth rates are highly discontinuous, and periodic crack arrest is observed after growth over distances of the order of tens of micrometres. Crack advance could only be resumed with an increase in the far-field stress intensity range. The mechanisms of short crack advance in cyclic tension are similar to those observed under quasi-static loads, and the tensile fatigue effect appears to be a manifestation of static failure modes. A model is presented to provide an overall framework for the tensile fatigue crack growth characteristics of partially stabilized zirconia. Experimental results are also described to demonstrate the possibility of stable room temperature crack growth under cyclic tension in fine-grained tetragonal zirconia polycrystals, partially stabilized with Y₂O₃. The growth of cracks in transformation-toughened ceramics is found to be strongly influenced by the crack size and shape, stress state and specimen geometry.     

Cyclic hot corrosion of Haynes 230 alloy

Cyclic hot corrosion conducted on Haynes 230 at temperatures of 871 and 1093 C indicated that catastrophic corrosion occurred. The corrosion rate was related to the high content of tungsten and chromium in the alloy. The concept of basic and acid fluxing was applied to explain the dissolution of the protective film of Cr₂O₃ and volatile WO₃ by an Na₂SO₄-rich liquid due to the formation of Na₂CrO₄ and Na₂WO₄. As the basic melts were acidified by continuously consuming oxygen ions, plate-like crystals of Cr₂O₃ were precipitated on the free surface by conversion from Na₂CrO₄. Acid fluxing was achieved by the refractory oxide, WO₃, consuming oxygen ions. The presence of sulphur suppressed the diffusion of chromium outward to form protective Cr₂O₃. Internal chromium-rich sulphide particles were observed. It was suggested that at very lowP _O2, sulphur reacted with chromium to form CrS initially. As oxygen penetrated through the porous layer, the CrS was oxidized internally to Cr₂O₃.     

Effects of bile salts on rat hepatic acyl CoA:Cholesterol acyltransferase

Acyl CoA:cholesterol acyltransferase (EC2.3.1.26, ACAT), responsible for intracellular esterification of cholesterol, may play an important role in cholesterol trafficking within the cell, and thus, in maintenance of cellular cholesterol homeostasis. Bile acids are potential regulators of cholesterol trafficking in the liver. Therefore, the effect of bile salts on hepatic ACAT activity was studied in the perfused rat liver. ACAT activity was increased after liver perfusion with either taurocholate or taurochenodeoxycholate. However, addition of these bile salts at physiological concentrationsin vitro had little effect on microsomal ACAT activity. The increase in hepatic ACAT activity due to perfusion with bile salts was accompanied by reduced accumulation of very low density lipoprotein cholesterol in the perfusate, but there was no effect on 3-hydroxy-3-methylglutaryl-CoA reductase activity. Hepatic ACAT activity was decreased after bile diversion for four hours in the intact animal. This treatment had no statistically significant effect on 3-hydroxy-3-methylglutaryl-CoA reductase activity. These data suggest that bile salts induce changes in hepatic compartmentation and traffic of cholesterol within the hepatocyte accompanied by response of ACAT activity to maintain cellular cholesterol homeostasis.     

User experience and personal innovativeness: An empirical study on the Enterprise Resource Planning systems

Although user experience and personal innovativeness are two important factors in new technology adoption, there has been no prior study to test these factors with the Enterprise Resource Planning (ERP) adoption. This paper investigates moderating roles of user experience on the relationship between the personal innovativeness and the ERP adoption motivations. This issue is important because if the user has more experience with the systems then the power of influence of personal innovativeness on ERP adoption motivation would be different. Thus, this paper tests these important insights of ERP systems adoption with the two different field samples with high (more than three years) and low (less than three years) user experience, based on the innovation diffusion theory, self determination theory, and different types of motivations such as intrinsic and extrinsic motivations. The findings, based on the PLS analysis of the model using 107 ERP end users, show that there are clear moderating effects of user experience—such as impacts of personal innovativeness on ERP systems adoption motivations are higher in case of low user experience samples, as expected. Academic and practical implications are discussed in the paper based on these empirical findings.     

Context matters: The structure of task goals affects accuracy in multiple-target visual search

Career visual searchers such as radiologists and airport security screeners strive to conduct accurate visual searches, but despite extensive training, errors still occur. A key difference between searches in radiology and airport security is the structure of the search task: Radiologists typically scan a certain number of medical images (fixed objective), and airport security screeners typically search X-rays for a specified time period (fixed duration). Might these structural differences affect accuracy? We compared performance on a search task administered either under constraints that approximated radiology or airport security. Some displays contained more than one target because the presence of multiple targets is an established source of errors for career searchers, and accuracy for additional targets tends to be especially sensitive to contextual conditions. Results indicate that participants searching within the fixed objective framework produced more multiple-target search errors; thus, adopting a fixed duration framework could improve accuracy for career searchers.     

Evaluation of thermal and evaporative resistances in cricket helmets using a sweating manikin

The main objective of this study is to establish an approach for measuring the dry and evaporative heat dissipation cricket helmets. A range of cricket helmets has been tested using a sweating manikin within a controlled climatic chamber. The thermal manikin experiments were conducted in two stages, namely the (i) dry test and (ii) wet test. The ambient air temperature for the dry tests was controlled to ∼23 °C, and the mean skin temperatures averaged ∼35 °C. The thermal insulation value measured for the manikin with helmet ensemble ranged from 1.0 to 1.2 clo. The results showed that among the five cricket helmets, the Masuri helmet offered slightly more thermal insulation while the Elite helmet offered the least. However, under the dry laboratory conditions and with minimal air movement (air velocity = 0.08 ± 0.01 ms⁻¹), small differences exist between the thermal resistance values for the tested helmets. The wet tests were conducted in an isothermal condition, with an ambient and skin mean temperatures averaged ∼35 °C, the evaporative resistance, R_et, varied between 36 and 60 m² Pa W⁻¹. These large variations in evaporative heat dissipation values are due to the presence of a thick layer of comfort lining in certain helmet designs. This finding suggests that the type and design of padding may influence the rate of evaporative heat dissipation from the head and face; hence the type of material and thickness of the padding is critical for the effectiveness of evaporative heat loss and comfort of the wearer. Issues for further investigations in field trials are discussed.     

Saturation-based switching anti-windup design for linear systems with nested input saturation

This paper proposes a saturation-based switching anti-windup design for the enlargement of the domain of attraction of a linear system subject to nested saturation. A nestedly saturated linear feedback is expressed as a linear combination of a set of auxiliary linear feedbacks, which form a convex hull where the nestedly saturated linear feedback resides. This set of auxiliary linear feedbacks is then partitioned into several subsets. The auxiliary linear feedbacks in each of these subsets form a convex sub-hull of the original convex hull. When the value of the nestedly saturated linear feedback falls into a convex sub-hull, it can be expressed as a linear combination of the subset of all the auxiliary feedbacks that form the convex sub-hull. A separate anti-windup gain is designed for each convex sub-hull by using a common quadratic Lyapunov function and is implemented when the value of the nestedly saturated linear feedback falls into this convex sub-hull. Simulation results indicate that such a saturation-based switching anti-windup design has the ability to significantly enlarge the domain of attraction of the closed-loop system.     

Improving class probability estimates for imbalanced data

Obtaining good probability estimates is imperative for many applications. The increased uncertainty and typically asymmetric costs surrounding rare events increase this need. Experts (and classification systems) often rely on probabilities to inform decisions. However, we demonstrate that class probability estimates obtained via supervised learning in imbalanced scenarios systematically underestimate the probabilities for minority class instances, despite ostensibly good overall calibration. To our knowledge, this problem has not previously been explored. We propose a new metric, the stratified Brier score, to capture class-specific calibration, analogous to the per-class metrics widely used to assess the discriminative performance of classifiers in imbalanced scenarios. We propose a simple, effective method to mitigate the bias of probability estimates for imbalanced data that bags estimators independently calibrated over balanced bootstrap samples. This approach drastically improves performance on the minority instances without greatly affecting overall calibration. We extend our previous work in this direction by providing ample additional empirical evidence for the utility of this strategy, using both support vector machines and boosted decision trees as base learners. Finally, we show that additional uncertainty can be exploited via a Bayesian approach by considering posterior distributions over bagged probability estimates.