New method for measuring an optical property of a sample treated by FWA

In this article, a new method for measuring a total spectral radiance factor of a FWA‐treated sample illuminated by a specific standard illuminant is introduced. The method replaces an unstable real fluorescent standard by a bi‐spectral luminescent radiance factor data, which works as a virtual fluorescent standard (VFS) by knowing spectral intensity distributions of illuminations applied to the sample. The method utilizes two illuminations I₁ and I₂ whose relative spectral intensity distributions are different from each other and synthesizes a virtual illumination presenting the identical fluorescent spectral radiance factor to that presented by the standard illuminant with the VFS of the specific bi‐spectral luminescent radiance factor by linearly combining I₁ and I₂ with the suitable weighting factors. The applicability of the method is examined in principle by comparing ISO brightness and CIE whiteness index of fluorescent standard paper as a test sample obtained by this new method to the assigned values. © 2007 Wiley Periodicals, Inc. Col Res Appl, 32, 195–200, 2007     

Further improvement in high crystalline quality of homoepitaxial CVD diamond

High-quality homoepitaxial diamond (001) films with macroscopically flat surfaces have been successfully grown using a high-power microwave-plasma chemical-vapor-deposition (MWPCVD) method. In this study, further optimization of the homoepitaxial growth condition has been accomplished mainly by controlling off-angles to 5° along the <110> or <100> direction of high-pressure/high-temperature-synthesized Ib diamond (001) substrates. We have found that the homoepitaxial films deposited at reasonably high growth rates under the optimized growth condition including the off-angle of 3°–4° along the <110> direction have macroscopically flat surfaces, accompany very low or almost negligible densities of growth hillocks and yield strong free-exciton emissions in both steady-state cathodoluminescence and time-resolved photoluminescence spectra measured at room temperature. These indicate that apparent lateral growths suitable for high-quality homoepitaxial layers in the case of the high-power MWPCVD method, which are similar to those previously reported in the case of MWPCVD processes with low methane concentrations, rather quickly occur from step edges on (001) terraces and that they can be achieved more preferentially on the vicinal substrates at high temperatures and high methane concentrations.     

CVD growth and field emission characteristics of nano-structured films composed of vertically standing and mutually intersecting nano-carbon sheets

Nano-structured films composed of rather flat nano-carbon sheets which roughly stood vertically on Si wafers and which intersected each other at large angles were grown by means of a high-power microwave-plasma chemical-vapour-deposition (MWPCVD) method. The structure of the fabricated films was investigated using scanning electron microscopes and Raman spectroscopy. Field emission (FE) currents obtained from these films reached 50 mA/cm² at a macroscopic electric field of 3.6 V/μm. The observed FE characteristics were analyzed using a modified Fowler–Nordheim (F–N) equation where the field enhancement factor and effective emission area were treated as field-dependent parameters. It was found from the analysis that the vertically standing nano-carbon flat sheets had larger field enhancement factors and less FE areas, compared with those obtained for wrinkled nano-carbon sheets previously reported by the authors. It is suggested that the observed variations in the FE current without saturation behavior as a function of the macroscopic electric field can be explained in terms of an effective surface geometry phenomenon of the concerned films.     

Evaluation technique of gate oxide damage

Gate oxide damage by plasma processing was evaluated using structures with various antenna lengths. The gate oxide damage by plasma processing was found to be monitored quantitatively by measuring the charge to breakdown, Q_BD. From the Q_BD measurements, we have confirmed that the degradation occurs during overetching, not in main etching. Plasma current was calculated from the decrease of Q_BD during the etching. The breakdown spot in the gate oxide was detected by photon emission and TEM. The LOCOS structure plays an important role for the degradation by plasma damage. In this paper, it is demonstrated that the Q_BD method is effective for realizing a highly reliable process against plasma damage     

Cytokines affecting survival and differentiation of an astrocyte progenitor cell line

The effects of various cytokines on survival and differentiation of an astrocyte progenitor cell line (AP-16) were examined. Epidermal growth factor (EGF) deprivation caused death of AP-16 cells by apoptosis. Transforming growth factor-alpha (TGF-alpha) and basic fibroblast growth factor (bFGF) prevented the apoptosis occurring in the absence of EGF. Leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) induced glial fibrillary acidic protein (GFAP) and decreased A2B5 antigen in AP-16 cells, indicating that these cytokines induced AP-16 cells to differentiate into astrocytes.     

Induction and measurement of antisperm antibody responses in vitro

We did a statistical study of 294 strains of Staphylococcus aureus (S. aureus) isolated from skin infections during the period from January of 1989 to December of 1991 in the Department of Dermatology, Kansai Medical University Hospital. We especially examined methicillin-resistant S. aureus (MRSA) from the point of view of incidence, variety of skin infections with MRSA, coagulase type, phase type, and resistance against antimicrobial agents. The frequency of isolation of MRSA has been increasing. In 1991, the proportion of MRSA isolates among all S. aureus strains isolated from skin infections was 41.5%. MRSA was isolated most often from infectious decubitus. Coagulase type II and phage group NT (not typable) MRSA were most frequently isolated. The resistance of MRSA to OFLX and IMP/CS had remarkably increased. Notably, the resistance to MINO was low before 1991.     

Development of enhanced depth-resolution technique for shallow dopant profiles

A rapid shrinkage in the minimum feature size of integrated circuits requires analysis of dopants in their shallow source–drain and their extensions with an enhanced depth resolution. Rutherford backscattering spectroscopy (RBS) combining a medium-energy He ion beam with a detector of improved energy resolution should meet the requirement of a depth resolution better than 5 nm at a depth of 10–20 nm in the next 10 years. A toroidal electrostatic analyzer of 4×10⁻³ energy resolution has been used to detect the scattered ions of a medium-energy He ion beam. Five keV As⁺ implanted Si or SiO₂ samples were measured. Depth profiling results using the above technique are compared with those of glancing-angle RBS by MeV energy He ions. Limitations in the energy resolution due to various energy-spread contributions have been clarified.     

Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines

Spontaneous proliferative liver lesions were found in 15 (13 males and 2 females) of 244 (122 of each sex) transgenic (Tg) mice carrying the human prototype c-H-ras gene (rasH2). The liver lesions included 3 foci of cellular alteration, 1 hepatocellular adenoma, 5 hepatocellular carcinomas, and 4 hepatic hemangiosarcomas in the males and 1 focus of cellular alteration and 1 hepatocellular carcinoma in the females. The mutation patterns of the human and endogenous mouse c-H-ras codon 61 in these proliferative liver lesions were analyzed by DNA amplification using polymerase chain reaction, single-strand conformation polymorphism (PCR-SSCP), and oligonucleotide dot blot hybridization. The hepatocellular carcinomas in 4 males and 1 female contained a point mutation in the mouse c-H-ras gene: 3, 1, and 1 carcinomas had a CAA to AAA transversion at the first base of codon 61, a CAA to CTA transversions, and a CAA to CGA transition at the second base of codon 61, respectively. No point mutations in the human c-H-ras transgene were detected in any hepatocellular carcinoma. All 4 hepatic hemangiosarcomas had a CAG to CTG transversion at codon 61 of the human c-H-ras gene, but no point mutations were detected in codon 61 of the mouse c-H-ras gene. No mutations in human or mouse c-H-ras codon 61 were detected in altered cell foci or hepatocellular adenoma. These results indicate that spontaneous liver tumors in rasH2 Tg mice contain different mutation patterns depending on the histologic type or cell origin of the tumors (i.e., hepatocellular carcinomas or hepatic hemangiosacomas). The absence of similar mutations in foci of cellular alteration and the hepatocellular adenoma suggests that the occurrence of codon 61 point mutations is a late event in the progression of hepatocellular neoplasia in rasH2 Tg mice.     

Effect of Mixing Time on the Lubricating Properties of Magnesium Stearate and the Final Characteristics of the Compressed Tablets

The effect of mixing time on hardness, disintegration time and ejection force in tablettlng of magnesium stearate and lactose granules was studied. The hardness of the tablets decreased with an increase in mixing time of the blends, as previously reported. A semilogarithmic plot of the hardness versus mixing time gave a straight line having a turning point. At the early phase of mixing the hardness was decreasing with a large first-order rate and then continued to decrease with another small first-order rate. The change in disintegration time or ejection force versus mixing time was basically the same as that in the hardness. This type of plot was applicable to the mixing magnesium stearate with not only granular but also powdered materials.