Mesencephalic microinjections of neurotensin-(1-13) and its C-terminal fragment, neurotensin-(8-13), potentiate brain stimulation reward

Using the curve shift method, we assessed the effects of ventromedial mesencephalic tegmental (VMT) microinjections of an equimolar concentration of neurotensin-(1-13) (NT-(1-13)) and of its C-terminal fragment, neurotensin-(8-13) (NT-(8-13)), on operant responding for rewarding electrical stimulation of the caudal mesencephalic central gray. The effects of NT-(1-13) and NT-(8-13) on brain stimulation reward (BSR) were also compared to those of systemically administered quinpirole (0.1 and 0.2 mg/kg, s.c.), a direct dopamine agonist, and GBR-12909 (10 and 20 mg/kg, i.p.), a selective dopamine uptake blocker. At the concentration injected, NT-(8-13) was as effective as NT-(1-13) at facilitating BSR, producing significant leftward shifts of the function relating the rate of responding to the stimulation frequency (R/F function); neither form of the peptide was effective when injected in regions dorsal to the VMT. Similarly, GBR-12909 produced a parallel leftward shift of the R/F function, but, unlike NT-(1-13), also significantly increased the asymptotic rates of responding. In contrast, the high dose of quinpirole produced non-parallel leftward shifts of the R/F function and suppressed the asymptote. The similarity between the effects of neurotensin and GBR-12909 on one hand, and the differences between those of neurotensin and quinpirole on the other, suggest that activation VMT neurotensin receptors potentiate BSR by enhancing increases in dopamine neurotransmission that are contingent upon operant responding or rewarding brain stimulation, or both.(ABSTRACT TRUNCATED AT 250 WORDS)     

The application of semantic classification trees to naturallanguage understanding

This article describes a new method for building a natural language understanding (NLU) system, in which the system's rules are learnt automatically from training data. The method has been applied to design of a speech understanding (SU) system. Designers of such systems rely increasingly on robust matchers to perform the task of extracting meaning from one or several word sequence hypotheses generated by a speech recognizer. We describe a new data structure, the semantic classification tree (SCT), that learns semantic rules from training data and can be a building block for robust matchers for NLU tasks. By reducing the need for handcoding and debugging a large number of rules, this approach facilitates rapid construction of an NLU system. In the case of an SU system, the rules learned by an SCT are highly resistant to errors by the speaker or by the speech recognizer because they depend on a small number of words in each utterance. Our work shows that semantic rules can be learned automatically from training data, yielding successful NLU for a realistic application     

A fluidelastic model for the dynamics of cantilevered plates with an additional spring support in axial flow

A fluidelastic model has been developed for studying the dynamics of cantilevered plates in axial flow, with an additional spring support at the plate trailing edge. The plate is supposed to be two-dimensional; a nonlinear equation of motion based on the inextensibility condition is used to account for the possible large vibration amplitude. For the fluid-dynamic part, an unsteady lumped vortex model is used for calculating the fluid loads acting on the plate undergoing deformation; the longitudinal displacement of the plate associated with lateral motions is also taken into account. The fluidelastic model is first validated through comparisons with experimental data published for systems without the spring support; it is then used to investigate the dynamics of cantilevered plates in axial flow with an additional spring support at the plate trailing edge. Some interesting results of the dynamics of the fluid–structure system are presented.     

Ultrasonic thin-walled tube wave structure for sensing devices

Theoretical and experimental investigations of thin-walled tube acoustic wave devices for gravimetric sensing applications are presented. Integrated sensor configurations have been demonstrated by employing a sol-gel processed thin piezoelectric lead zirconate titanate (PZT) film. This was coated coaxially on stainless steel tubes and interdigital transducers (IDT) fabricated as the transmitter and receiver on the curved tube surfaces. We have observed tube waves along both the axial and circumferential directions between 1 and 6.6 MHz. We have also analyzed the mass sensitivities of different modes propagating along the tubes and shown that high mass sensitivity can be achieved by keeping the tube wall thin     

A new approach to version control

A method for controlling versions of software and other hierarchically structured entities is presented. Using the variant structure principle, a particular version of an entire system is formed by combining the most relevant existing versions of the various components of the system. An algebraic version language that allows histories (numbered series), subversions (or variants), and joins is described. It is shown that the join operation is simply the lattice least upper bound and together with the variant structure principle, provides a systematic framework for recombining divergent variants. The utility of this approach is demonstrated using LEMUR, a programming environment for modular C programs, which was developed using itself. The ways in which this notion of versions is related to the possible world semantics of intensional logic are discussed     

Frequency-domain characterization of Kalman filters as applied topower system protection

So far, all tests on Kalman filters have been performed in the time domain. However, it is shown that conventional signal-processing tools such as frequency response can be successfully applied for the performance analysis. The concept of frequency response as applied to Kalman filters is based on its variation with time. Consequently, it is defined with respect to a definite observation window. It is also shown that the ratio of the initial error covariance matrix terms to the measurement noise variance, not the absolute values, is the relevant statistical quantity. The same principle applies to the ratio of the process noise covariance matrix diagonal terms to the noise measurement variance     

Infant leukaemia biology, aetiology and treatment

A method for the determination of aspartame (N-L-alpha-aspartyl-L-phenylalanine methyl ester) and its metabolites, applicable on a routine quality assurance basis, is described. Liquid samples (diet Coke, 7-Up, Pepsi, etc.) were injected directly onto a mini-cartridge reversed-phase column on a high-performance liquid chromatographic system, whereas solid samples (Equal, hot chocolate powder, pudding, etc.) were extracted with water. Optimising chromatographic conditions resulted in resolved components of interest within 12 min. The by-products were confirmed by mass spectrometry. Although the method was developed on a two-pump HPLC system fitted with a diode-array detector, it is straightforward and can be transformed to the simplest HPLC configuration. Using a single-piston pump (with damper), a fixed-wavelength detector and a recorder/integrator, the degradation of products can be monitored as they decompose. The results obtained were in harmony with previously reported tedious methods. The method is simple, rapid, quantitative and does not involve complex, hazardous or toxic chemistry.     

Effect of oil viscosity on transformer loading capability at lowambient temperatures

The applicability of the ANSI loading guide for power transformers is limited to ambient temperatures above 0°C because the thermal model does not account for variations in the oil viscosity and winding resistance. A practical calculation method based on the bottom-oil temperature and the surface temperature at the top of the cooling duct has been developed. Results indicate that the proposed thermal model could provide a sound basis for calculating the overload capacity for ambient temperatures below 0°C or for severe overloads of short duration     

The interactive editing and contouring of empirical fields

A system for the interactive editing and contouring of surfaces derived from empirical fields is described. The approach taken begins with the representation of a field as a general-order, nonuniform, tensor-product, B-spline surface. It provides an interactive display for editing the surface by control-vertex manipulation and a contouring algorithm that is specifically designed for the fast and robust contouring of B-spline surfaces. Interactive editing of the resulting model is feasible because of the local nature of editing changes when B-splines are used. The use of nonuniform B-splines gives the flexibility required to model highly irregular data efficiently     

Wavelet domain-based video noise reduction using temporal discrete cosine transform and hierarchically adapted thresholding

A novel spatio-temporal filter for video denoising, which operates entirely in the wavelet domain, is proposed. For effective noise reduction, the spatial and temporal redundancies that exist in the wavelet domain representation of a video signal are exploited. First, a 2D discrete wavelet transform is applied to the input noisy frames. This is followed by a discrete cosine transform (DCT), which is applied to the temporal subband coefficients to minimise the redundancy among the consecutive frames. The DCT transformed, noise-free coefficients in the different wavelet domain subbands for the original image sequence are modelled using a prior having a generalised Gaussian distribution. On the basis of this prior, filtering of the noisy wavelet coefficients in each subband is carried out using a new, low-complexity wavelet shrinkage method, which utilises the correlation that exists between subsequent resolution levels. Experimental results show that the proposed scheme outperforms several state-of-the-art spatio-temporal filters in terms of both the peak signal-to-noise ratio and the visual quality