A Multistage-Responsive Antibody-Delivery Strategy to Improve Immunotherapy for NSCLC Brain Metastasis by Ultrasensitive Releasing and Tumor-Anchoring

Immune checkpoint blockade (ICB) therapy has emerged as a promising approach in clinical oncology. For brain metastases, the presence of the robust blood–brain barrier (BBB) and potential immune-related adverse events (irAEs) pose significant challenges. Here, a multistage-responsive antibody-delivery strategy is developed for non-small cell lung cancer (NSCLC) brain metastases, with the ultra-pH sensitivity borate bonds. The antibody-delivery nanoformulation (MB-aPDL1) is able to maintain the “silent state” in health tissue, cross the BBB/BTB by the GLUT1-mediated transcytosis, release the functionalized aPDL1 responsively, and promote the aPDL1 tumor-anchoring. In the in vivo tumor region, the MB-aPDL1 rapidly releases the activated BPA₆-aPDL1, which successfully anchors to the tumor cells and improves the efficiency of ICB therapy. The two in vivo ICB therapy studies show a significant tumor growth inhibition from the MB-aPDL1 with an encouraging cure rate of 20% for the NSCLC brain metastases, due to enhanced immune response in tumor, commendably with less behavioral adverse reactions and liver damage. Taken together, this antibody-delivery strategy holds substantial potential for application in clinical treatment of brain metastases.     

打浆对漂白针叶木浆纤维素酶作用效果的影响

漂白针叶木浆经PFI不同转数打浆,然后用纤维素酶Celluclast 1.5L进行处理,探讨了打浆对漂白针叶木浆纤维素酶作用效果的影响。结果表明,漂白针叶木浆经适当打浆后再进行酶处理,还原糖生成量增加29.38%,水解效率显著增加,聚合度下降明显,说明打浆能够促进纤维素酶在纤维表面吸附;随着打浆转数的增加,酶处理后纸浆中细小纤维含量增加幅度降低,纸浆游离度和保水值增加幅度提高,说明打浆能够促进纤维素酶对纤维结晶区的水解作用。     

楞型对瓦楞结构材料瓦楞方向准静态力学性能的影响

目的研究不同楞型瓦楞结构材料在准静态条件下对瓦楞方向相关力学性能的影响。方法通过有限元模拟的方法,在准静态压缩条件下,得到不同楞型的瓦楞结构材料在瓦楞方向上的变形模式、应力-应变曲线等,通过能量效率法对其峰应力、密实化应变、平均抗压强度和单位体积吸收能量等进行对比分析。结果在同一壁厚条件下,A,C,B,E这4种楞型的峰应力、平均抗压强度、单位体积吸收能量依次增大;对于任一楞型来说,峰应力、平均抗压强度、单位体积吸收能量随壁厚的增大而增大,且与其呈线性关系;随着壁厚的增大,A,C,B,E这4种楞型的峰应力、平均抗压强度、单位体积吸收能量的增长幅度依次增大。结论楞型对瓦楞结构材料瓦楞方向的力学性能有显著影响,在其他条件相同的情况下,A,C,B,E这4种楞型的力学性能依次增强。     

两款木包装箱的生命周期影响分析及对比

目的 研究木包装箱在全生命周期过程中对环境的影响,对比钢边箱和传统木箱对环境的影响.方法 通过全生命周期分析软件eBalance分析2款木包装箱从产品生产、物流运输到使用后的废物管理整个生命周期的物耗、能耗及向环境中的排放,对其数据清单进行分类、特征化和归一化计算,得到木包装箱3个流程的主要环境影响类型和对应指标值.结果 传统木箱在产品生产、物流运输和废物管理流程的LCIA加权综合指标分别为6.87514×10?9,1.93549×10?12,5.20×10?13,其中胶合板生产在产品生产过程中的占比为99.86％,胶合板处理在废物管理过程中的占比为99.82％;钢边箱在产品生产、物流运输和废物管理流程的LCIA加权综合指标分别为6.53463×10?9,3.57256×10?13,2.96531×10?13,其中胶合板生产在产品生产过程中的占比为97.43％,胶合板处理在废物管理过程中的占比为99.38％;钢边箱对环境影响的总量比传统木箱小约5％.结论 木包装箱全生命周期的环境影响主要体现在胶合板的生产和废物管理过程中,木包装箱在设计、生产加工、运输、废弃物处理等方面都有较大的改进余地,钢边箱比传统木箱更具有环境友好性,对木包装箱绿色化的生产设计具有参考意义.     

Fishing Net-Inspired Mutiscale Ionic Organohydrogels with Outstanding Mechanical Robustness for Flexible Electronic Devices

Mechanically robust and electrically conductive organohydrogels/hydrogels are increasingly required in flexible electronic devices, but it remains a challenge to achieve organohydrogels/hydrogels with integrated high performances. Herein, inspired by the geometric deformability and robustness of fishing nets, multiscale ionic organohydrogels with outstanding isotropic mechanical robustness are developed. The organohydrogels are prepared by introducing polyacrylamide (PAM) hydrogel, Zn²⁺ and a binary solvent of glycerol-water into a crosslinked fibrous mat which is electrospun from poly(acrylic acid) (PAA) and poly(vinyl alcohol) (PVA). Because of the unique structure, the resultant organohydrogels, being mentioned as PAA-PVA/PAM/Zn²⁺ organohydrogels, exhibit outstanding tensile strength (9.45 MPa), high stretchability, excellent anti-fatigue property, skin-like mechanical behaviors and ionic conductivity. Importantly, the organohydrogels are promising in flexible electronic devices capable of operating properly over a wide temperature range and under harsh mechanical conditions, such as mechanical-electrical signal transducing materials in flexible mechanosensors and robust electrolytes in zinc ion hybrid supercapacitors. Not only the multiscale design strategy will provide a clue to improve the mechanical properties of soft materials, but also the organohydrogels offer promising materials for future flexible electronic devices.