诱发电位反卷积技术的不适定问题及正则化解决方法

连续循环平均反卷积 (Continuous loop averaging deconvolution, CLAD) 是近年来用于提取高刺激率模式下听觉诱发电位(Audi t ory evoked potential, AEP)的一种行之有效的方法。但是,CLAD方法在频率域求解时,对 刺 激序列的频谱特性有严格的限制,给应用带来不便和局限。本文提出一种在时域实现反卷积 的方法,将其转化为线性变换矩阵的逆滤波处理。并且利用奇异值分解分析了由不良序列带 来的不适定问题,引入正则化技术改善病态矩阵对重建结果的影响。最后比较了若干种 典型刺激序列和不同噪声条件下AEP的恢复实验,结果表明本方法可以较好地解决不良序列 和一般噪声水平条件下暂态AEP信号的恢复重建。     

基于凹点搜寻的重叠细胞图像自动分离的算法研究

提出了一种重叠细胞图像自动分离的新算法。根据重叠细胞的凹凸性,从细胞重叠区域的凹区域中寻找到凹点,根据凹点数与细胞个数的关系,判断是细胞串联还是细胞并联：如果是串联的情况,则直接将成对的凹点连成直线分离重叠区域;如果是并联的情况,则将凹点与重叠区域的中心连接成直线分离重叠区域。该算法在Matlab环境下对重叠细胞图像进行了自动分离,实验结果表明该算法实现简单,效果理想,且能基本保持原细胞的大小和形状。     

参与中文配对词语联想学习记忆的脑区和神经机制——脑功能磁共振的研究

通过脑功能磁共振技术,研究健康人参与语言的词语配对联想学习记忆任务的脑区和神经机制。对16名右利手健康志愿者进行一项词语配对联想学习记忆任务作业的同时,进行脑功能磁共振扫描。实验采用组块设计,实验任务（包括记忆编码相和记忆提取相）与对照任务（共两个相）交替进行;数据采用SPM99软件进行数据分析和脑功能区定位。结果表明：左侧额叶,特别是左侧额叶的额中下回和枕叶的18,19区在词语联想学习记忆的编码阶段中起重要作用;而左侧顶上小叶、缘上回和角回则在进行记忆提取阶段起重要作用;左侧纹状体边缘区参与了人脑词语联想学习记忆作业的编码阶段。揭示了人大脑完成语言联想学习记忆任务时,除额、顶、枕和颞叶的皮层结构参与外,还新发现有皮层下结构如纹状体参与了词语联想学习记忆。在配对词语的编码和提取阶段,激活的脑区有所变化,显示了这两个语言阶段的神经活动变化机制。     

灾害救援实时最快通行路径算法

灾害救援需要物资人力的快速运输,而突发灾害常会影响到道路的通行状态,研究道路网络动态变化情况下救援车辆的实时最快通行路径算法,具有重要的经济和社会意义.针对灾害发生后道路状况多变突变的情况,提出一种实时最快通行路径求解算法ARFTP(Algorithm of Real-time Fastest Traffic Path),将结点进行分类筛选,依据相应准则进行运算,减少了需要重新计算的结点和路径数量.当车辆行驶在原定救援最快通行路径上时,实时收到路段变化信息,根据ARFTP求解策略可快速求出新的最快通行路径.通过仿真验证了算法的有效性和效率,对提高灾害救援运输效率具有一定的意义.     

Using computers for the treatment of psychological problems

Approximately two dozen efforts in the published literature to deliver counseling or other psychological intervention services are critically reviewed, and several issues considered basic to significant progress are discussed. Primary attention is given to examining the use of computers in cognitive psychotherapy, games, computer-aided instruction, biofeedback and behavior therapy, and other related approaches to psychotherapy. Evidence presented in this review leads to the conclusion that computers can make meaningful contributions to the treatment of psychological problems. The limited ability of current computer programs to process natural language is highlighted as the most significant impediment to continued progress in this area.     

脑卒中血浆脂肪酸及其代谢产物的UPLC-MS分析

脑卒中是一类高致残率、高死亡率的脑血管疾病,分为缺血性脑卒中和出血性脑卒中2种亚型,二者具有相似的临床症状,但治疗策略完全不同.目前,主要依赖医学影像学技术进行诊断,但存在耗时、费用高、难以区分2种脑卒中亚型等缺点,进而影响疾病治疗和预后.本研究收集了59例健康志愿者、60例急性脑缺血和36例脑出血患者的血浆样本,运用...     

The chemistry of structural defects in CuInSe2

The composition of CuinSe₂ can be described by two parameters, non-stoichiometry and non-molecularity. The concentration variation of the structural defects on thermal annealing is predicted as a function of two component activities. Even though the electrical properties can be interpreted within the model of vacancy defects, the establishment of any defect model must await their identification by structure-sensitive techniques.     

Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy

Photodynamic therapy(PDT)is a widely-used technology for cancer therapy,but conventional photosensitizers still face some drawbacks,such as hydrophobicity,inadequate pharmacokinetics,low cell/tissue specificity,and uncontrollable photodynamic performance during the therapeutic process.Herein,we present a controllable photodynamic performance based on two-dimensional metal-organic frameworks(2D Zn-TCPP MOF)that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP.However,the 2D Zn-TCPP MOF showed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure.From the in vitro outcomes,the 2D Zn-TCPP MOF showed controllable photodynamic performance from neutral to acidic environments.Due to the acidic tumor microenvironment,the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under irradiation with a 660 nm laser.This work offers a promising strategy to develop a next-generation photosensitizer.     

基于区域相关的图像加密效果评定方法

随着图像加密技术的发展,出现了各种各样的加密方法,其中有基于Arnold变换、仿射变换、Hilbert曲线、幻方、骑士巡游、Gray码、混沌序列和基于频域的置乱加密技术,但是却缺少一种能有效衡量这些方法的置乱程度及反映加密次数与置乱程度关系的标准。提出了一种新的基于区域相关的判断置乱程度的方法。实验结果表明该方法能有效衡量置乱程度及反映加密次数与置乱程度的关系。     

基于FMS的高清视频服务器的研究

在当今网络视频发展的过程中。高清视频,多用户,大并发流是视频点播发展的必然趋势。该文从分析flash media server系统入手,提出了一种应用于高校内部高速网的高清视频服务的设计方案,并对该系统的体系机构和各个组成部分进行了改进,重点是针对用户的VCR操作,视频文件的内热度等。对视频文件进行分盘分区分段存储。从而大幅度降低了服务拒绝率,减少了用户等待时间[1]。