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111.
112.
Azizli Mohammad Javad Barghamadi Mohammad Rezaeeparto Katayoon Mokhtary Masoud Parham Somayeh Darabi Mehdi Joker 《Iranian Polymer Journal》2021,30(10):1001-1018
Iranian Polymer Journal - Effects of graphene oxide (GO) on various properties of rubber hybrid nanocomposites based on PVMQ/XNBR-g-GMA/XNBR (phenyl-vinyl-methyl-polysiloxane/carboxylated nitrile... 相似文献
113.
Lan Chen Yan Zhang Karin Pacheco Shaodong Dai 《International journal of molecular sciences》2021,22(5)
Nickel (Ni2+) is one of the most common allergens, affecting around 10–15% of the general population. As the demand for orthopedic implant surgery rises, the number of surgical revisions due to joint implant failure also increases. There is evidence that some patients develop joint failure due to an immune response to a component of the implant, and we have found that Ni2+ is an especially important cause. Hence, understanding the mechanisms by which Ni2+ allergy induces joint implant failure becomes a critical research question. The structural basis of Ni2+ activation of pathogenic T cells is still not clear. The purpose of this study was to characterize Ni2+-reactive T cell repertoires derived from the peripheral blood of joint failure patients due to Ni2+ sensitization using single-cell sequencing techniques. We stimulated the proliferation of Ni2+ -reactive T cells from two implant failure patients in vitro, and sorted them for single-cell VDJ sequencing (10× genomics). We identified 2650 productive V-J spanning pairs. Both TCR α chains and β chains were enriched. TRBV18 usage is the highest in the P7 CD4+ population (18.1%), and TRBV5-1 usage is the highest in the P7 CD8+ population (12.1%). TRBV19 and TRBV20-1 segments are present in a high percentage of both P7 and P9 sequenced T cells. Remarkably, the alpha and beta chain combination of TRAV41-TRBV18 accounts for 13.5% of the CD4+ population of P7 patient. Compared to current Ni specific T cell repertoire studies of contact dermatitis, the Vα and Vβ usages of these joint implant failure patients were different. This could be due to the different availability of self-peptides in these two different tissues. However, TRBV19 (Vβ17) was among frequently used TCR β chains, which are common in previous reports. This implies that some pathogenic T cells could be similar in Ni2+ hypersensitivities in skin and joints. The alignment of the TCR CDR3β sequences showed a conserved glutamic acid (Glu) that could potentially interact with Ni2+. The study of these Ni2+ specific TCRs may shed light on the molecular mechanism of T cell activation by low molecular weight chemical haptens. 相似文献
114.
Natalia Ziemkiewicz Genevieve Hilliard Nicholas A. Pullen Koyal Garg 《International journal of molecular sciences》2021,22(6)
Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide variety of innate and adaptive immune cells orchestrate the complex process of muscle repair. This review provides information about the various types of immune cells and biomolecules that have been shown to mediate muscle regeneration following injury and degenerative diseases. Recently developed cell and drug-based immunomodulatory strategies are highlighted. An improved understanding of the immune response to injured and diseased skeletal muscle will be essential for the development of therapeutic strategies. 相似文献
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117.
Claudia Penna Saveria Femmin Fabrizio Caldera Alberto Rubin Pedrazzo Claudio Cecone Edoardo Alfì Stefano Comit Takanobu Higashiyama Francesco Trotta Pasquale Pagliaro Roberta Cavalli 《International journal of molecular sciences》2021,22(8)
Heart failure (HF) prevalence is increasing among the aging population, and the mortality rate remains unacceptably high despite improvements in therapy. Myocardial ischemia (MI) and, consequently, ischemia/reperfusion injury (IRI), are frequently the basis of HF development. Therefore, cardioprotective strategies to limit IRI are mandatory. Nanocarriers have been proposed as alternative therapy for cardiovascular disease. Controlled reoxygenation may be a promising strategy. Novel nanocarriers, such as cyclic nigerosyl-nigerose (CNN), can be innovative tools for oxygen delivery in a controlled manner. In this study we analyzed new CNN-based formulations as oxygen nanocarriers (O2-CNN), and compared them with nitrogen CNN (N2-CNN). These different CNN-based formulations were tested using two cellular models, namely, cardiomyoblasts (H9c2), and endothelial (HMEC) cell lines, at different concentrations. The effects on the growth curve during normoxia (21% O2, 5% CO2 and 74% N2) and their protective effects during hypoxia (1% O2, 5% CO2 and 94% N2) and reoxygenation (21% O2, 5% CO2 and 74% N2) were studied. Neither O2-CNN nor N2-CNN has any effect on the growth curve during normoxia. However, O2-CNN applied before hypoxia induces a 15–30% reduction in cell mortality after hypoxia/re-oxygenation when compared to N2-CNN. O2-CNN showed a marked efficacy in controlled oxygenation, which suggests an interesting potential for the future medical application of soluble nanocarrier systems for MI treatment. 相似文献
118.
预焙铝电解槽阳极钢爪自焙保护环优化技术 总被引:1,自引:0,他引:1
就目前预焙铝电解槽所用的自焙保护环的制作进行了研究.提出了优化方案,通过工业试验认为.自焙保护环的制作技术优化后.可以给企业创造显著的经济效益。 相似文献
119.
Fanqin Meng Steven F. Dec Don Williamson Phat Pham Michael A. Yandrasits Andrew M. Herring 《Electrochimica acta》2007,53(3):1372-1378
A perfluorosulfonic acid (PFSA) polymer with pendant side chain -O(CF2)4SO3H was doped with the heteropoly acids (HPAs), H3PW12O40 and H4SiW12O40. Infrared spectroscopy revealed a strong interaction between the HPA and the PFSA ionomer. Modes associated with the peripheral bonds of the HPA were shifted to lower wave numbers when doped into PFSA membranes. Small-angle X-ray scattering (SAXS) measurements showed the presence of large crystallites of HPA in the membrane with d spacings of ca. 10 Å, close to the lattice spacing observed in bulk HPA crystals. Under wet conditions the HPA was more dispersed and constrained the size of the sulfonic acid clusters to 20 Å at a 5 wt% HPA doping level, the same as in the vacuum treated ionomer samples. Under conditions of minimum hydration the HPA decreased the Ea for the self-diffusion of water from 27 to 15 kJ mol−1. The reverse trend was seen under 100% RH conditions. Proton conductivity measurements showed improved proton conductivity of the HPA doped PFSAs at a constant dew point of 80 °C for all temperatures up to 120 °C and at all relative hummidities up to 80%. The activation energy for proton conduction generally was lower than for the undoped materials at RH ≤80%. Significantly the Ea was 1/2 that of the undoped material at RHs of 40 and 60%. A practical proton conductivity of 113 mS cm−1 was observed at 100 °C and 80% RH. 相似文献
120.
利用自行搭建的CO2膜吸收实验台,采用聚丙烯(PP)膜组件,以质量分数10%的N-甲基二乙醇胺(MDEA)作为主体胺溶液,添加不同配比的哌嗪(PZ)、乙醇胺(MEA)、甘氨酸钾(PG),考察CO2脱除效率和传质速率的变化,比较不同复配比的复合溶液表面张力以及对PP膜的浸润性,并以10%MDEA+10%PG混合溶液作为吸收液进行长时间实验。结果表明:添加少量的添加剂对MDEA溶液膜吸收CO2均有显著的促进作用,当配比小于0.2时,促进作用大小为PZ>MEA>PG;当配比大于0.2时,促进作用大小为PZ>PG>MEA;PZ和MEA均随着添加配比的增加,溶液表面张力减小,而PG相反;表面张力小的溶液对膜浸润性较强,容易造成膜润湿;添加剂质量分数均为10%时,对膜溶胀性和疏水性以及膜孔结构影响大小为PZ>MEA>PG;在20天内,PG/MDEA混合溶液作用下的CO2脱除效率从89.56%下降为83.09%,对PP的疏水性影响较小,膜组件可以稳定运行。吸收液表面张力对膜吸收法脱除CO2性能的影响显著。所得结果可为膜吸收CO2吸收剂复配提供依据,并可为揭示膜吸收CO2过程中膜润湿导致膜失效的机理以及抑制膜润湿提供实验数据。 相似文献