基于禁忌算法的快速公交网络系统仿真优化

针对传统数学规划方法处理BRT网络系统优化存在的局限性,提出了一类直达乘客量最大化的BRT网络规划问题并建立了数学模型。设计了该优化模型的禁忌算法。多次仿真实验结果表明模型合理,算法有效。     

制造流程规划中多层次仿真分析模型

根据制造型企业的特点,将工业工程理论、最优生产技术和计算机仿真技术结合,应用到生产系统制造流程规划中,提出了多层次仿真分析模型.分别运用虚拟生产线物流系统规划方法、Flexsim2.6仿真软件和标准作业组合票,从三个层次对典型汽齿行业制造流程进行仿真分析.确定了最佳搬运批量及频率,并根据仿真结果,识别了3个瓶颈工序;结合精益生产,提出生产线制造流程改善方案,使得工作单元减少了2个,生产线节拍缩短了2秒,产量提高了10%.     

早期建筑师对城市低收入住宅的探索

发达国家进入城市化后,建筑师们为解决由此而产生的城市低收入阶层的住房问题进行了早期探索和研究。通过低收入阶层公共住宅设计课题的提出到实践历程的分析,为我国解决这一复杂问题提供理论支持和实践经验。     

Stress rupture and creep behavior of a low pressure plasma-sprayed NiCoCrAlY coating alloy in air and vacuum

Low pressure plasma-sprayed MCrAlY overlayer coatings are used for surface protection on superalloy components for gas turbine engines. In this work, an NiCoCrAlY alloy, PWA 276, deposited as thick plates by low pressure plasma spraying was studied in constant load creep-rupture tests conducted in air and vacuum at 660 and 850°C for various stresses. In addition, some specimens were pre-exposed in air or vacuum for 100 h at 1050°C prior to testing in air.At 660 and 850°C, rupture lives were two to three times longer in air than in vacuum. The second-stage creep rates were independent of test environment. However, during tests in air, tertiary creep began later, progressed at a lower rate and continued to a greater strain at fracture than during tests in vacuum. In comparison, specimens pre-exposed in air at 1050°C exhibited a greater time to the onset of tertiary creep, but the same strain at fracture as as-machined specimens also tested in air. Failure in both environments was essentially by void growth; however, during tests in vacuum many surface cracks extending from micropores also formed and linked up with the internal voids. Testing in air apparentlu increases the ductility of the alloy surface, preventing stable surface crack growth until the alloy ruptures because of a reduction in the load-bearing area. A decrease in the second-stage creep rate which occurred on pre-exposure at 1050°C, whether in air or vacuum, has been attributed to precipitation hardening. A precipitated phase within the λ phase was observed by scanning and transmission electron microscopy but is not yet identified.     

路面橡胶集料混凝土抗折强度的试验研究

橡胶集料混凝土作为一种新型混凝土材料具有极好的抗裂性能,良好的抗冲击载荷和能量耗散能力,作新型的路面材料非常适用。通过对掺入较高比例的橡胶集料混凝土(最高可达150kg/m3)的抗折试验,分析了橡胶集料混凝土抗折强度的主要影响因素,建立抗折强度的经验公式,并对公式的合理性进行验证。然后对橡胶集料混凝土的抗折强度与抗压强度之间的相关关系进行讨论。     

河口首站含油污水综合处理技术的研究

针对河口首站原油分离出来的污水存在悬浮物(SS)、细菌、硫化物含量严重超标、污水呈臭"黑水",无法满足油田注水系统要求的系列问题,作者研究了脱硫净化和杀菌技术,通过药剂筛选和现场试验,说明了药剂对污水处理的巨大效果,同时配合污水过滤的生产工艺,形成了一套实用高效的污水综合处理技术,处理后的水质达到了油田注水B2级标准要求,满足了油田生产要求.     

高密度液体碳氢燃料合成及应用进展

介绍了高密度碳氢燃料合成及应用的最新进展.从原料、合成路线、性能特征、成本等方面评价了各种高密度碳氢燃料的优缺点和应用前景.分析了高密度碳氢燃料合成与应用的共性特征,提出燃料分子设计与定向合成、燃料复配等急需解决的问题,提出了下一步工作的重点.     

一种改进的足球机器人射门算法

提出一种改进的射门算法.通过路径规划,使得机器人沿着平滑的轨迹将位姿调整到射门状态,然后,根据位姿变化最小的原则,从对方门线的坐标点中选择射门目标点,以圆弧路径完成射门过程.试验表明,算法可以提高射门成功率.     

Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand Interactions

As the etiological agent for the coronavirus disease 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenges the ongoing efforts of vaccine development and drug design. Due to the accumulating cases of breakthrough infections, there are urgent needs for broad-spectrum antiviral medicines. Here, we designed and examined five new tetrapeptidomimetic anti-SARS-CoV-2 inhibitors targeting the 3C-Like protease (3CL^Pro), which is highly conserved among coronaviruses and essential for viral replications. We significantly improved the efficacy of a ketoamide lead compound based on high-resolution co-crystal structures, all-atom simulations, and binding energy calculations. The inhibitors successfully engaged the catalytic dyad histidine residue (H41) of 3CLPro as designed, and they exhibited nanomolar inhibitory capacity as well as mitigated the viral loads of SARS-CoV-2 in cellular assays. As a widely applicable design principle, our results revealed that the potencies of 3CL^Pro-specific drug candidates were determined by the interplay between 3CL^Pro H41 residue and the peptidomimetic inhibitors.     

Actin-Associated Proteins and Small Molecules Targeting the Actin Cytoskeleton

Actin-associated proteins (AAPs) act on monomeric globular actin (G-actin) and polymerized filamentous actin (F-actin) to regulate their dynamics and architectures which ultimately control cell movement, shape change, division; organelle localization and trafficking. Actin-binding proteins (ABPs) are a subset of AAPs. Since actin was discovered as a myosin-activating protein (hence named actin) in 1942, the protein has also been found to be expressed in non-muscle cells, and numerous AAPs continue to be discovered. This review article lists all of the AAPs discovered so far while also allowing readers to sort the list based on the names, sizes, functions, related human diseases, and the dates of discovery. The list also contains links to the UniProt and Protein Atlas databases for accessing further, related details such as protein structures, associated proteins, subcellular localization, the expression levels in cells and tissues, mutations, and pathology. Because the actin cytoskeleton is involved in many pathological processes such as tumorigenesis, invasion, and developmental diseases, small molecules that target actin and AAPs which hold potential to treat these diseases are also listed.