用模糊层次分析法优选矿山废水治理方案

针对某矿山酸性废水治理工程实际,建立评价结构体系,采用模糊综合评判与层次分析法相结合的综合评判方法对备选方案进行综合决策.过程采用模糊综合评判法构造指标优度值判断矩阵,采用线性目标规划模型求得逼近决策者偏好的指标优度排序矩阵,采用层次分析法(AHP)确定指标权重,采用Matlab软件进行LP规划及矩阵特征值、特征向量计算,最后通过方案总排序确定了工程优选方案.模糊层次分析法有效解决了方案选择过程中评价指标的模糊性问题,提高了方案优选过程的效率及优选结果的准确性.     

矿山酸性废水源头控制与德兴铜矿杨桃坞、祝家废石场和露天采场清污分流工程

总结国内外矿山酸性废水源头控制技术的原理和要点,介绍德兴铜矿杨桃坞、祝家废石场和露天采场防止和减少酸性废水的清污分流工程。采用拦、截、排、泄等措施,德兴铜矿每年可控制和减少向大坞河排放酸性废水250~350万t,改善大坞河水质效果显著,同时节省了大量处理费用。     

Plant flavonol quercetin and isoflavone biochanin A differentially induce protection against oxidative stress and inflammation in ARPE-19 cells

In this work, differential ability of plant flavonol quercetin and plant isoflavone biochanin A to modulate oxidative stress and inhibit inflammation-related responses was investigated using human retinal pigment epithelial cells (RPE) at gene expression level. Quercetin protected cells from oxidative stress-induced cell death, whereas biochanin A had no statistically significant protective effects. Quercetin reduced the expression of cytokines IL-6 and IL-1?? in cells treated with H₂O₂, and expression levels of Nrf2 and HO-1 were increased by quercetin treatment suggesting protective function against oxidative stress. Our data indicate that quercetin may protect cells by inhibiting the production of pro-inflammatory factors such as IL-6, and by inducing the expression of ROS-catalyzing phase II proteins such as HO-1. Therefore, plant extracts rich in flavonol quercetin may be an interesting resource for functional food products and other foods targeted for reduced risks of age-related macular degeneration.     

结构模型与控制器降阶的主动控制试验研究

土木工程结构模型的自由度数目较大，从而导致主动控制和半主动控制实施过程中时滞效应十分突出，本文采用均衡截断技术研究了结构和控制器降阶的两种方法。第一种方法是首先采用均衡实现技术得到内部均衡系统，再根据Hankel矩阵奇异值的大小对结构模型进行降阶．对降阶的结构系统设计低阶的线性二次调节（LQ）和H∞控制器；第二种方法是对原结构模型设计LQ和H∞控制器，再采用均衡实现技术对控制器进行降阶，得到低阶控制器模型。通过大量的仿真和地震模拟振动台试验，研究了所建立方法的可行性和有效性。     

Genetic Association Analysis of Anti-VEGF Treatment Response in Neovascular Age-Related Macular Degeneration

Anti-VEGF treatment for neovascular age-related macular degeneration (nAMD) has been FDA-approved in 2004, and since then has helped tens of thousands of patients worldwide to preserve vision. Still, treatment responses vary widely, emphasizing the need for genetic biomarkers to robustly separate responders from non-responders. Here, we report the findings of an observational study compromising 179 treatment-naïve nAMD patients and their reaction to treatment after three monthly doses of anti-VEGF antibodies. We show that established criteria of treatment response such as visual acuity and central retinal thickness successfully divides our cohort into 128 responders and 51 non-responders. Nevertheless, retinal thickness around the fovea revealed significant reaction to treatment even in the formally categorized non-responders. To elucidate genetic effects underlying our criteria, we conducted an undirected genome-wide association study followed by a directed replication study of 30 previously reported genetic variants. Remarkably, both approaches failed to result in significant findings, suggesting study-specific effects were confounding the present and previous discovery studies. Of note, all studies so far are greatly underpowered, hampering interpretation of genetic findings. In consequence, we highlight the need for an extensive phenotyping study with sample sizes exceeding at least 15,000 to reliably assess anti-VEGF treatment responses in nAMD.     

An Exploratory Study Provides Insights into MMP9 and Aβ Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients

Matrix metalloproteinase-9 (MMP9) and total amyloid-beta (Aβ) are prospective biomarkers of ocular ageing and retinopathy. These were quantified by ELISA in the vitreous and blood from controls (n = 55) and in a subset of age-related macular degeneration (AMD) patients (n = 12) for insights and possible additional links between the ocular and systemic compartments. Vitreous MMP9 levels in control and AMD groups were 932.5 ± 240.9 pg/mL and 813.7 ± 157.6 pg/mL, whilst serum levels were 2228 ± 193 pg/mL and 2386.8 ± 449.4 pg/mL, respectively. Vitreous Aβ in control and AMD groups were 1173.5 ± 117.1 pg/mL and 1275.6 ± 332.9 pg/mL, whilst plasma Aβ were 574.3 ± 104.8 pg/mL and 542.2 ± 139.9 pg/mL, respectively. MMP9 and Aβ showed variable levels across the lifecourse, indicating no correlation to each other or with age nor AMD status, though the smaller AMD cohort was a limiting factor. Aβ and MMP9 levels in the vitreous and blood were unrelated to mean arterial pressure. Smoking, another modifiable risk, showed no association with vitreous Aβ. However, smoking may be linked with vitreous (p = 0.004) and serum (p = 0.005) MMP9 levels in control and AMD groups, though this did not reach our elevated (p = 0.001) significance. A bioinformatics analysis revealed promising MMP9 and APP/Aβ partners for further scrutiny, many of which are already linked with retinopathy.     

基于AMD PC的机群计算系统的设计与实现

文章介绍了一个基于AMDPC的机群计算系统,它由30个计算节点、1个数据服务器及1个登录服务器组成,总共64个CPU,数据服务器使用千兆网络的连接。这个计算系统是用于LHC(LargeHadronCollider)的MonteCarlo模拟以及羊八井中日合作项目的数据分析、MonteCarlo模拟等。由于MonteCarlo模拟部分对计算能力的要求很高,而数据分析部分则对I/O能力的要求很高,因此系统必须兼顾这两个方面的要求。由于物理数据的产生和物理数据的分析是事例间无关的,所以系统使用批作业处理方式。该文选择NASA开发的自由软件PBS作为批作业管理系统。测试结果表明,系统SPEC2000的SPECint和SPECfp值分别为38976和35008,I/O的读写能力分别为62.34MB/s和56.50MB/s,具有很好的性能价格比。     

基于超短期风电功率预测的混合储能控制策略研究

为了改善风机出力特性,提出了一种基于超短期风电功率预测的混合储能控制策略。首先,利用解析模态分解方法从风电信号中提取低频信号,采用了一种改进布谷鸟方法优化支持向量机的惩罚因子参数和核函数参数进行超短期功率预测;然后,对低频预测信号建立1 min时间尺度和30 min时间尺度的功率波动并网指标,判断是否触发蓄电池动作,若动作,采用AMD分解自适应调整低频预测信号的截止频率,直到满足并网要求,确定蓄电池补偿功率指令。最后根据蓄电池荷电状态和补偿功率指令自适应调节原始风电信号截止频率,高频信号通过模糊控制由超级电容器补偿。仿真算例表明,该方法可以有效平滑功率波动,减少蓄电池的循环次数,同时保证了蓄电池储能的平滑能力,避免过充过放,延长蓄电池的寿命。     

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway

Age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, is a degenerative disease of the macula, where retinal pigment epithelium (RPE) cells are damaged in the early stages of the disease, and chronic inflammatory processes may be involved. Besides aging and lifestyle factors as drivers of AMD, a strong genetic association to AMD is found in genes of the complement system, with a single polymorphism in the complement factor H gene (CFH), accounting for the majority of AMD risk. However, the exact mechanism of CFH dysregulation confers such a great risk for AMD and its role in RPE cell homeostasis is unclear. To explore the role of endogenous CFH locally in RPE cells, we silenced CFH in human hTERT-RPE1 cells. We demonstrate that endogenously expressed CFH in RPE cells modulates inflammatory cytokine production and complement regulation, independent of external complement sources, or stressors. We show that loss of the factor H protein (FH) results in increased levels of inflammatory mediators (e.g., IL-6, IL-8, GM-CSF) and altered levels of complement proteins (e.g., C3, CFB upregulation, and C5 downregulation) that are known to play a role in AMD. Moreover, our results identify the NF-κB pathway as the major pathway involved in regulating these inflammatory and complement factors. Our findings suggest that in RPE cells, FH and the NF-κB pathway work in synergy to maintain inflammatory and complement balance, and in case either one of them is dysregulated, the RPE microenvironment changes towards a proinflammatory AMD-like phenotype.     

PDT照射方式下激光视网膜热损伤阈值的研究

建立了光动力疗法(PDT)照射方式下578nm激光视网膜热损伤能量密度阈值计算的数值模型。模型由模拟激光能量在组织内分布规律的基于网格的Monte Carlo模拟方法、计算组织内温度分布的考虑组织热物性参数以及血液灌注率动态变化的Penens生物传热方程和计算组织热损伤程度的Arrhenius方程3部分组成。数值结果表明,视网膜热损伤能量密度阈值随黑色素含量、观测时间和光斑大小不同而不同:黑色素含量越高,热损伤能量密度阈值越小;观测时间越长,热损伤能量密度阈值越大;光斑直径越大,热损伤能量密度阈值越小。活体动物实验验证了数值结果的精确性。